Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline

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成果类型：

期刊论文

作者：

Mei, Yufei;Jiang, Chun;Wan, You;Lv, Jihui;Jia, Jianping;...

通讯作者：

Yang, Xu

作者机构：

[Wang, Xiaomin; Mei, Yufei; Yang, Xu; Jia, Jianping; Tong, Zhiqian] Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China.

[Mei, Yufei; Yang, Xu] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan 430079, Peoples R China.

[Wan, You; Jiang, Chun] Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China.

[Wan, You; Jiang, Chun] Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100191, Peoples R China.

[Lv, Jihui] Beijing Geriatr Hosp, Beijing 100049, Peoples R China.

通讯机构：

[Yang, Xu] C

Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China.

语种：

英文

关键词：

formaldehyde;long-term potentiation;norepinephrine;senescence-accelerated prone 8;spatial memory;spontaneous discharge

期刊：

Aging Cell

ISSN：

1474-9718

年：

2015

卷：

期：

页码：

659-668

DOI：

10.1111/acel.12345

基金类别：

Beijing Institute for Brain Disorders [0000040103]; Scientific Research Common Program of Beijing Municipal Commission of EducationBeijing Municipal Commission of Education [KM201510025014]; Natural Scientific Foundation of CCMU [2015ZR31]; Natural Scientific Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC 31171080, 51136002]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

A norepinephrine (NE) deficiency has been observed in aged rats and in patients with Alzheimer’s disease and is thought to cause cognitive disorder. Which endogenous factor induces NE depletion, however, is largely unknown. In this study, we investigated the effects of aging-associated formaldehyde (FA) on the inactivation of NE in vitro and in vivo, and on memory behaviors in rodents. The results showed that age-related DNA demethylation led to hippocampal FA accumulation, and when this occurred, the hippocampal NE content was reduced in heal...

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Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline

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