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A Novel Approach to Breast Cancer-Related Disease Genes Discovered Through Variation of Density Modularity

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成果类型:
期刊论文、会议论文
作者:
Shen, Xianjun*;Yi, Yang;Wang, Yan;Chen, Xiaohui;Yang, Jincai(杨进才);...
通讯作者:
Shen, Xianjun
作者机构:
[Yang, Jincai; Shen, Xianjun; Chen, Xiaohui; He, Tingting; Yi, Yang; Wang, Yan] Cent China Normal Univ, Sch Comp, Wuhan, Peoples R China.
通讯机构:
[Shen, Xianjun] C
Cent China Normal Univ, Sch Comp, Wuhan, Peoples R China.
语种:
英文
关键词:
disease genes;breast cancer;internal closely associated degree;external closely associated degree;protein-protein interaction network
期刊:
2014 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)
ISSN:
2156-1125
年:
2014
页码:
22-27
会议名称:
IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM)
会议论文集名称:
IEEE International Conference on Bioinformatics and Biomedicine-BIBM
会议时间:
NOV 02-22, 2014
会议地点:
Univ Ulster, Belfast, NORTH IRELAND
会议主办单位:
Univ Ulster
会议赞助商:
IEEE, Natl Sci Fdn, Nsilico, Comp Sci Res Inst, BioBusiness, IEEE Comp Soc, Engn Res Inst, Biomed Sci Res Inst
主编:
Zheng, H Hu, X Berrar, D Wang, Y Dubitzky, W Hao, JK Cho, KH Gilbert, D
出版地:
345 E 47TH ST, NEW YORK, NY 10017 USA
出版者:
IEEE
ISBN:
978-1-4799-5669-2
机构署名:
本校为第一且通讯机构
院系归属:
计算机学院
摘要:
Breast cancer is a leading cause of cancer-related deaths in women worldwide. Discovery of breast cancer-related disease genes is becoming very important to researcher and opens a new way to investigate pathogenic mechanism of breast cancer. Many studies have shown that the availability of human genome-wide protein-protein interactions (PPI) provides us with new opportunity for discovering disease-genes by topological features in PPI network. Therefore, it's a novel idea that map disease genes to proteins and predict disease genes by analyzing ...

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