This work was supported by the National Natural Science Foundation of China, China (81973097, 22022404, and 22074050), the Royal Society International Exchanges Scheme (IEC\NSFC\201116), the Academy of Medical Sciences/Wellcome Trust (Springboard Grant, SBF007\100054), the Joint Fund project of Hubei Provincial Health Commission (WJ2019H197), and the Key Research and Development project in Hubei Province (2020BCB022).