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Efficient synthesis of thieno[2,3-d]pyrimidin-4(3H)-ones by a sequential aza-Wittig reaction/base catalyzed cyclization

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成果类型:
期刊论文
作者:
Dai, Zhong-Xu;Chen, Hong*;Liu, Ming-Guo;Ding, Ming-Wu
通讯作者:
Chen, Hong
作者机构:
[Dai, Zhong-Xu; Liu, Ming-Guo; Chen, Hong] China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China.
[Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构:
[Chen, Hong] C
China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China.
语种:
英文
关键词:
aza-Wittig reaction;carbodiimide;iminophosphorane;thieno[2,3-d]pyrimidin-4(3H)-one
期刊:
HETEROCYCLIC COMMUNICATIONS
ISSN:
0793-0283
年:
2011
卷:
17
期:
5-6
页码:
197-201
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21102084]; Science Foundation of Hubei Province Education Department, China [D20091301]; Excellent Fund for Scientific Research and Special Projects in China Three Gorges University, China [KJ2009B004]
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
7-Benzyl-5,6,7,8-tetrahydropyrido[4 ' ,3 ' :4,5]thieno[2,3-d] pyrimidin-4(3 H)-ones were synthesized by base catalyzed reactions of nucleophilic reagents (aliphatic amines, alcohols or phenols) with carbodiimides 4 , which in turn were obtained by the aza-Wittig reaction of iminophosphoranes 3 with aromatic isocyanates. 20...

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