期刊论文

Chao Qi<&wdkj&>Jinlin Liu

英文

Gene

0378-1119

2022

841

146771

10.1016/j.gene.2022.146771

CRediT authorship contribution statement Li Zhang: Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization. Fan Zhao: Data curation, Investigation, Methodology. Huan Xu: Data curation, Investigation, Methodology. Yubing Chen: Data curation, Investigation. Chao Qi: Conceptualization, acquisition, Methodology, Project administration, Writing – review & editing. Jinlin Liu: Conceptualization, Formal analysis, acquisition, Project administration, Resources, Software, Supervision,

本校为第一机构

Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, which is a severe and often fatal disease that results in significant economic loss. The means by which A. pleuropneumoniae survives within the host are not clear. High temperature requirement A (HtrA) proteases have been shown to affect cell viability during stressful conditions and are virulence factors in many bacterial species. In this study, we examined the biological role of HtrA during A. pleuropneumoniae infection by analyzing the impact of htrA mutation on virulence-associated phenotypes. We found that ...