National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61532008]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU17TS0003]
机构署名:
本校为第一且通讯机构
院系归属:
计算机学院
摘要:
Genome-wide association studies (GWAS) of T2D have discovered a number of loci that contribute to susceptibility to the disease. In this paper, we classified and identified the suspected risky Loci of T2D with computational method based on the known T2D GWAS-associated SNPs. The framework includes two parts: we first classified the SNPs based on their features of position and function through a simplified classification decision tree which was constructed by C4.5 decision tree algorithm; we then identified whether the genes associated with the suspected risky SNPs are associated with T2D by us...