期刊论文

Cai, Meng;He, Hongwu

英文

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

0021-8561

2019

67

45

12538-12546

10.1021/acs.jafc.9b02878

National Research and Development Plan [2017YFD0200506]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21877047, 31701820, 21472062, 21907035]; 111 ProjectMinistry of Education, China - 111 Project [B17019]; Natural Science Foundation of Hubei Province of ChinaNatural Science Foundation of Hubei Province [2017CFB232]; National Key Research Development Program of China [2018YFD0200100]

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Cyanobacteria harmful algal blooms are of global concern, but all currently available algicides in the market are nonselective and have potential side effects on nontarget species. In the present work, two series of compounds (4 and 6) comprising 16 novel 1,2,3-triazole aminopyrimidines were rationally designed and synthesized as control agent for cyanobacteria. Our design focus was the inhibiting cyanobacteria by inhibition against pyruvate dehydrogenase complex E1 (PDHc-E1). Compounds 4 and 6 showed potent inhibition against Escherichia coli PDHc-E1 (IC50 = 4.13-23.76 muM) and also strong al...