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Construction of a combinatorial library of 2-(4-oxo-4H-1-benzopyran-3-yl)-4-thiazolidinones by microwave-assisted one-pot parallel syntheses

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成果类型:
期刊论文
作者:
Zhou, Zhong‐Zheng;Huang, Wei;Ji, Feng‐Qin;Ding, Ming‐Wu;Yang, Guang‐Fu(杨光富
通讯作者:
Yang, Guang-Fu
作者机构:
[Yang, Guang‐Fu; Huang, Wei; Zhou, Zhong‐Zheng; Ji, Feng‐Qin; Yang, GF; Ding, Ming‐Wu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构:
[Yang, Guang-Fu] C
Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
语种:
英文
期刊:
Heteroatom Chemistry
ISSN:
1042-7163
年:
2007
卷:
18
期:
4
页码:
381-389
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A one‐pot liquid‐phase combinatorial synthesis of 2‐(4‐oxo‐4H‐1‐benzopyran‐3‐yl)‐4‐thiazolidinones bearing diverse substituents at the 3‐position under microwave irradiation was successfully performed using 3‐formyl chromone, primary amine, and mercaptoacetic acid as reactants. Compared to an identical library generated by conventional parallel synthesis, the microwave‐assisted parallel synthesis approach dramatically decreased the reaction time from an average of 9 h to 5 min, and substantially increased the product yields. The c...

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