Based on the kinetic model of genetic regulation system proposed by Smolen et al. [ Am. J. Physiol. 274 , c531 (1998)], the effects of fluctuations in the degradation reaction rate and the synthesis reaction rate of the transcription factor have been investigated through numerical computation and analysis theory. In the case of uncorrelated noises, it is shown that only the fluctuation of degradation reaction rate can induce a switch process, and the mean first passage time (MFPT) from the high concentration state to the low concentration one i...
