期刊论文

Jia, Feng-Cheng;Wu, An-Xin（吴安心）

英文

ADVANCED SYNTHESIS & CATALYSIS

1615-4150

2018

360

12

2267-2271

10.1002/adsc.201800180

We are grateful to the National Natural Science Foundation of China (Grant Nos. 21772051, 21602070 and 21472056) and the Fundamental Research Funds for the Central Universities (CCNU15ZX002) for financial support. We acknowledge the graduate student educational innovation grant from Central China Normal University (2017CXZZ030). This work was also supported by the 111 Project B17019.

本校为第一且通讯机构

An efficient potassium persulfate mediated four component reaction for the construction of 5-methyl pyrimidine derivatives has been established from readily available methyl ketones, amidine hydrochlorides and dimethyl sulfoxide. This transformation features dimethyl sulfoxide as a dual synthon, acting as the precursors of the methyl and methine units. Four new chemical bonds, involving two C−C and two C−N bonds were formed sequentially during the intermolecular oxidative annulation process. This synthetic method offers several advantages inc...