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Thymic Stromal Lymphopoietin Neutralization Inhibits the Immune Adjuvant Effect of Di-(2-Ethylhexyl) Phthalate in Balb/c Mouse Asthma Model

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成果类型:
期刊论文
作者:
You, Huihui;Li, Rui;Wei, Chenxi;Chen, Shaohui;Mao, Lin;...
通讯作者:
Yang, Xu;Zhang, Zhenye
作者机构:
[Li, Rui; You, Huihui; Chen, Shaohui; Yang, Xu; Mao, Lin] Cent China Normal Univ, Sch Life Sci, Lab Environm Biomed, Wuhan, Peoples R China.
[Wei, Chenxi] Hunan Normal Univ, Coll Life Sci, Key Lab Ecol Safety Monitoring & Evaluat, Changsha, Hunan, Peoples R China.
[Zhang, Zhenye] Cent China Normal Univ, Univ Hosp, Wuhan, Peoples R China.
通讯机构:
[Yang, Xu; Zhang, Zhenye] C
Cent China Normal Univ, Sch Life Sci, Lab Environm Biomed, Wuhan, Peoples R China.
Cent China Normal Univ, Univ Hosp, Wuhan, Peoples R China.
语种:
英文
关键词:
Immunologic adjuvants;Inflammation;Asthma;Allergies;Cytokines;Mouse models;Allergens;Phthalates
期刊:
PLOS ONE
ISSN:
1932-6203
年:
2016
卷:
11
期:
7
页码:
e0159479
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21577045, 51136002]
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
Di-(2-ethylhexyl) phthalate (DEHP), a commonly used plasticizer, has an adjuvant effect in combination with ovalbumin (OVA). The adjuvant effect of DEHP has already been verified in our previous studies. In this study, to further investigate whether thymic stromal lymphopoietin (TSLP) was involved in the DEHP-adjuvant effect, DEHP was administered through a daily gavage exposure route. Mice were sensitized with ovalbumin (OVA) to trigger allergic responses, and an anti-TSLP monoclonal antibody was used to neutralize the effect of TSLP. Biomarkers including cytokines in bronchoalveolar lavage f...

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