One-Pot Synthesis of Polysubstituted Pyrroles via Sequential Ketenimine Formation/Ag(I)-Catalyzed Alkyne Cycloisomerisation Starting from Ylide Adducts
[Ding, Ming-Wu] Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Jun Xiong] S
[Ming-Wu Ding] K
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, Central China Normal University, Wuhan, Hubei, 430079 China<&wdkj&>School of Pharmacy, Hubei University of Science and Technology, Xianning, Hubei, 437100 China
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21572075]; 111 ProjectMinistry of Education, China - 111 Project [B17019]; Research Project of Hubei Provincial Department of Education [Q20192806]; Doctoral Research Fund of Hubei University of Science and Technology [BK201808]
机构署名：
本校为其他机构
院系归属：
化学学院
摘要：
A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(I)-catalyzed alkyne cycloisomerisation has been developed. The easily accessible phosphorane ylide derivatives reacted with isocyanates, producing highly active ketenimines that were then treated with amines, which afforded substituted pyrroles by a 5-exo-dig cyclization/isomerization in the pr...
