期刊论文

Fu, Liwu

英文

European Journal of Medicinal Chemistry

0223-5234

2012

48

379-384

10.1016/j.ejmech.2011.12.014

National Basic Research Program of ChinaNational Basic Research Program of China [2010CB126100]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21172090, 21002037]; PCSIRTProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT0953]; CCNU from the colleges' basic research and operation of MOEMinistry of Education, Singapore [CCNU10A01007]

本校为第一机构

A series of O,O′-dialkyl {[2-(substituted phenoxy)acetamido] (substituted phenyl)methyl}phosphonates was synthesized and their cytotoxic activities were tested against various human tumor cell lines. Some compounds (5q, 5r, 5s, 5w, 5x and 5y) showed relatively high cytotoxicity. Especially, compounds 5x and 5q exhibited the best cytotoxicity against KB and CNE2 cells with IC 50 7.1 and 11.4 μM, respectively. Their inhibitory activities against KB and CNE2 cells were even higher than that ...