Formaldehyde induces toxicity in mouse bone marrow and hematopoietic stem/progenitor cells and enhances benzene-induced adverse effects

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wei, Chenxi;Wen, Huaxiao;Yuan, Langyue;McHale, Cliona M.;Li, Hui;...

通讯作者：

Yang, Xu;Zhang, Luoping

作者机构：

[Wei, Chenxi; Yuan, Junlin; Yuan, Langyue; Wen, Huaxiao; Yang, Xu; Li, Hui; Wang, Kun] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

[Zhang, Luoping; McHale, Cliona M.] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.

[Wei, Chenxi] Hunan Normal Univ, Coll Life Sci, Key Lab Ecol Safety Monitoring & Evaluat, Changsha 410081, Hunan, Peoples R China.

[Wang, Kun] NYU, Sch Med, Dept Populat Hlth, Div Biostat, New York, NY USA.

通讯机构：

[Yang, Xu] C

[Zhang, Luoping] U

Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.

语种：

英文

关键词：

Formaldehyde;Benzene;Hematotoxicity;Bone marrow;Myeloid progenitor

期刊：

Archives of Toxicology

ISSN：

0340-5761

年：

2017

卷：

期：

页码：

921-933

DOI：

10.1007/s00204-016-1760-5

基金类别：

National Natural Science Foundation of China-Key ProgramNational Natural Science Foundation of China (NSFC) [51136002]; National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01ES017452]; Excellent Doctoral Dissertation Cultivation Grant from Central China Normal University [2013YBYB67]; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [R01ES017452, R01ES017452] Funding Source: NIH RePORTER

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

Formaldehyde (FA) is a human leukemogen and is hematotoxic in human and mouse. The biological plausibility of FA-induced leukemia is controversial because few studies have reported FA-induced bone marrow (BM) toxicity, and none have reported BM stem/progenitor cell toxicity. We sought to comprehensively examine FA hematoxicity in vivo in mouse peripheral blood, BM, spleen and myeloid progenitors. We included the leukemogen and BM toxicant, benzene (BZ), as a positive control, separately and together with FA as co-exposure occurs frequently. We ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Formaldehyde induces toxicity in mouse bone marrow and hematopoietic stem/progenitor cells and enhances benzene-induced adverse effects

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问