Tetrasubstituted Carbon Stereocenters via Copper-Catalyzed Asymmetric Sonogashira Coupling Reactions with Cyclic gem-Dihaloketones and Tertiary α-Carbonyl Bromides

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成果类型：

期刊论文

作者：

Mo, Xueling;Huang, Han;Zhang, Guozhu

通讯作者：

Zhang, Guozhu(guozhuzhang@sioc.ac.cn)

作者机构：

[Zhang, Guozhu; Mo, Xueling] Cent China Normal Univ CCNU, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, CCNU uOttawa Joint Res Ctr,Key Lab Pesticides & Ch, Wuhan 430079, Hubei, Peoples R China.

[Zhang, Guozhu; Huang, Han] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Chinese Acad Sci, Ctr Excellence Mol Synth,State Key Lab Organometal, Shanghai 200032, Peoples R China.

通讯机构：

[Guozhu Zhang] C

CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health. College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China<&wdkj&>State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China

语种：

英文

关键词：

tertiary alkyl halides;copper-catalyzed;Sonogashira reaction;enantioselective;tetrasubstituted carbon stereocenters

期刊：

ACS CATALYSIS

ISSN：

2155-5435

年：

2022

卷：

期：

页码：

9944-9952

DOI：

10.1021/acscatal.2c01973

基金类别：

The authors are grateful to the National Natural Science Foundation of China (22071073, 21772218, and 21821002), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB20000000), State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences and the Central China Normal University (CCNU).

机构署名：

本校为第一机构

院系归属：

化学学院

摘要：

The construction of chiral tetrasubstituted carbon stereocenters is an ongoing challenge in synthetic organic chemistry due to its prevalence in multiple disciplines. One efficient approach is the catalytic asymmetric C-C coupling reactions of a readily available racemic tertiary alkyl electrophile by simple organic nucleophiles. While a variety of secondary alkyl halides succeeded in asymmetric Cu-catalyzed Sonogashira-type cross-coupling reactions with diverse alkynes, tertiary alkyl halides have rarely been used in this kind of coupling reac...

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Tetrasubstituted Carbon Stereocenters via Copper-Catalyzed Asymmetric Sonogashira Coupling Reactions with Cyclic gem-Dihaloketones and Tertiary α-Carbonyl Bromides

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