期刊论文

Xu Yang

英文

生物学前沿

1674-7984

2015

10

3

279-286

10.1007/s11515-015-1344-4

This work was supported by the National Natural Science Foundation of China （Grant No. 51136002） and the 12th Five- Year Key Program for Science and Technology Development of China （No. 2012BAJ02B0301）.

本校为第一且通讯机构

Magnesium-aluminum layered double hydroxide (Mg/Al-LDH) nanoparticles have strong potential application as drug delivery systems because of their low toxicity and suitable biocompatibility. However, few studies have described the morphological effects of these hydroxides on nerve cells. The present study compares the oxidative stress induced by different concentrations (i.e., 0, 50, 100, 200, 400, and 800 μg/mL) of sand flower and flake nano-Mg/Al-LDHs in mouse neuroblastoma cells (N2a) when these cells were exposed for 24 and 48 h. Cell viabi...

镁铝分层的双氢氧化物(Mg/Al-LDH ) nanoparticles 因为他们的低毒性和合适的 biocompatibility，作为药交货系统有强壮的潜在的申请。然而，很少研究在神经细胞上描述了这些氢氧化物的词法效果。现在的学习比较不同集中导致的氧化压力(即， 0， 50， 100， 200， 400，和 800 g/mL ) 在老鼠 neuroblastoma 房间(N2a ) 的沙花和薄片 nano-Mg/Al-LDHs 当这些房间为 24 和 48 h 被暴露时。房间生存能力被 MTT 试金检测，并且反应的氧种类(ROS ) 的生产，谷胱甘肽(GSH ) ，和 malondialdehyde (MDA ) 被监视评估氧化损坏。结果建议了那沙花 nano-LDHs，在适当集中(不到 200 g/mL ) ，特别那些在尺寸...