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Expression of the alternative splicing variants of bcl6b in medaka Oryzias latipes

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成果类型:
期刊论文
作者:
Zhang, Runshuai;Ke, Xiaomei;Wu, Kongyue;Shen, Hao;Nibona, Emile;...
通讯作者:
Zhao, Haobin
作者机构:
[Zhang, Runshuai; Wu, Kongyue; Shen, Hao; Al Hafiz, Abdullah; Nibona, Emile; Ye, Weiyuan; Ke, Xiaomei; Liang, Xiaoting; Zhou, Qingchun; Zhao, Haobin; Zhong, Xueping] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Zhao, Haobin] C
Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
关键词:
bcl6b;Expression;Immune stimuli;Medaka;Splicing variant
期刊:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
ISSN:
1096-4959
年:
2019
卷:
227
页码:
83-89
基金类别:
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31672284, 31272645]
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
Bcl6B, also known as BAZF, plays important roles in the immune response, repression of cancers, and maintenance of spermatogonial stem cells in mammals. In this study, the homologous gene bcl6b and its 5 alternative splicing variants, namely bcl6bX1 to bcl6bX5, were isolated from medaka fish, Oryzias latipes. Medaka bcl6b possesses conserved domains such as BTB domain, RD2 domain and four zinc fingers. Medaka bcl6bX1 to bcl6bX3 possess all three previously mentioned domains with minor differences in sequences. Medaka bcl6bX4 possesses only the BTB domain due to premature stopping, and bcl6bX5 ...

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