Membrane disruption boosts iron overload and endogenous oxidative stress to inactivate Escherichia coli by nanoscale zero-valent iron

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成果类型：

期刊论文

作者：

Wang, Jian;Liu, Congcong;Sun, Hongwei;Wang, Shaohui;Liao, Xiaomei;...

通讯作者：

Hongwei Sun<&wdkj&>Xiaomei Liao

作者机构：

[Wang, Jian; Liu, Congcong; Liao, Xiaomei; Wang, Shaohui] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

[Zhang, Lizhi; Sun, Hongwei] Cent China Normal Univ, Inst Environm & Appl Chem, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.

通讯机构：

[Hongwei Sun] K

[Xiaomei Liao] H

Hubei Key Lab of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China<&wdkj&>Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, PR China

语种：

英文

关键词：

*Bacteria;*Iron uptake;*Membrane;*Nanoscale zero-valent iron;*ROSs

期刊：

Journal of Hazardous Materials

ISSN：

0304-3894

年：

2022

卷：

435

页码：

128951

DOI：

10.1016/j.jhazmat.2022.128951

基金类别：

CRediT authorship contribution statement Jian Wang: Investigation, Visualization, Writing – original draft. Congcong Liu: Investigation, Validation. Hongwei Sun: Conceptualization, Supervision, Methodology, Writing – review & editing, acquisition. Shaohui Wang: Writing – review & editing. Xiaomei Liao: Supervision, Writing – review & editing. Lizhi Zhang: Supervision, Writing – review & editing.

机构署名：

本校为第一机构

院系归属：

生命科学学院

化学学院

摘要：

The inactivation of microorganisms by nanoscale zero-valent iron (nZVI) was extensively reported, but what happens inside the cells is rarely explored. Herein, we revealed that nZVI caused the drastic increase of intracellular iron concentrations, which subsequently catalyzed the Haber-Weiss reaction to produce high levels of endogenous reactive oxygen species (ROSs) and inactivated E. coli cells by oxidative damage of DNA, evidenced by the significantly higher inactivation efficiencies of E. coli mutant strains deficient in iron uptake regulation and DNA repair than the parental strain. The i...

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Membrane disruption boosts iron overload and endogenous oxidative stress to inactivate Escherichia coli by nanoscale zero-valent iron

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