期刊论文

中文

环境与健康杂志

1001-5914

2004

21

4

215-217

10.16241/j.cnki.1001-5914.2004.04.011

国家科技攻关项目

本校为第一机构

目的探讨不同处理组小鼠呼吸器官(气管、支气管、肺)中P物质(substance P,SP)含量变化和气道神经源性的神经受体机制.方法用不同浓度的气态甲醛对小鼠进行灌流染毒,然后测量呼吸器官中P物质含量变化;预注射不同受体的拮抗剂的小鼠,再用不同浓度的气态甲醛进行灌流染毒,然后测量呼吸器官中P物质含量变化,进行对比分析.结果吸人2.42 mg/m3甲醛的小鼠呼吸器官中P物质含量较空气灌流组显著上升(P＜0.05),吸入4.81 mg/m3甲醛的小鼠呼吸器官中P物质含量较空气灌流组极显著上升(P＜0.01).腹部皮下预注射N-甲基-D-天(门)冬氨酸(NMDA)受体拮抗剂0.2 mol/L MgSO4 0.5ml,再空气灌流的小鼠呼吸器官中P物质的...

Objective To explore the contents of substance P (SP) in respiratory organs and the neuro-receptor mechanism of airway neurogenic inflammation induced by gaseous formaldehyde. Methods SP contents in respiratory organs of mice exposed to different concentrations of gaseous formaldehyde and SP contents in respiratory organs of mice pre-injected different receptor antagonist, then exposed to different concentrations of gaseous formaldehyde were determined by radioimmunoassay. Results SP content in respiratory organs of mice inhaled 2.42 mg/m3 form...