期刊论文

Xiao, Wen-Jing;Chen, Jia-Rong

英文

Nature Communications

2041-1723

2021

12

1

1815

10.1038/s41467-021-22127-x

We are grateful to the financial support from the National Natural Science Foundation of China (Nos. 21971081, 91856119, 21772053, 21820102003, and 91956201), the Program of Introducing Talents of Discipline to Universities of China (111 Program, B17019), and the Excellent Doctoral Dissertation Cultivation Grant to P.Z.W. from CCNU.

本校为第一机构

The intermolecular three-component alkene vicinal dicarbofunctionalization (DCF) reaction allows installation of two different carbon fragments. Despite extensive investigation into its ionic chemistry, the enantioseletive radical-mediated versions of DCF reactions remain largely unexplored. Herein, we report an intermolecular, enantioselective three-component radical vicinal dicarbofunctionalization reaction of olefins enabled by merger of radical addition and cross-coupling using photoredox and copper dual catalysis. Key to the success of this protocol relies on chemoselective addition of ac...