National Basic Research ProgramNational Basic Research Program of China [2016YFA0201603]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11505193, 11475195, 91543118, U1432245]
机构署名：
本校为通讯机构
院系归属：
生命科学学院
摘要：
Inflammatory bowel diseases (IBD) are widespread inflammatory diseases that cause debilitating health problems including cancer. In this study, we show that ZnO nanoparticle (ZnONP) treatment has markedly dose-dependent effects on the remission of dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. We demonstrate the mechanism involves the antioxidant and anti-inflammatory abilities of ZnONPs to suppress ROS and malondialdehyde (MDA) production; increase GSH level; suppress proinflammatory cytokines IL-1β and TNF-α and myeloperox...
