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Recent Applications of Triazolopyrimidine-Based Bioactive Compounds in Medicinal and Agrochemical Chemistry

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成果类型:
期刊论文
作者:
Qu Renyu;Liu Yuchao;Wishwajith, W. M.;Kandegama, W.;Qiong, Chen*;...
通讯作者:
Qiong, Chen
作者机构:
[Qiong, Chen; Liu Yuchao; Wishwajith, W. M.; Kandegama, W.; Qu Renyu; Yang Guangfu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
[Qiong, Chen] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Qiong, Chen] C
Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
关键词:
5 amino 2 (2 furyl) 7 (2 phenylethyl)pyrazolo[4,3 e][1,2,4]triazolo[1,5 c]pyrimidine;adenosine receptor blocking agent;cisplatin;dihydroorotate dehydrogenase;dihydroorotate dehydrogenase inhibitor;doxorubicin;enzyme inhibitor;prednisolone;pyrimidine derivative;adenosine receptor blocking agent;agricultural chemical;antiinfective agent;antineoplastic agent;antiparasitic agent;enzyme inhibitor;nonsteroid antiinflammatory agent;pyrimidine derivative;antibacterial activity;antifungal activity;antiinflammatory activity;antineoplastic activity;asthma;biological activity;drug effect;drug efficacy;drug mechanism;drug potency;drug screening;drug selectivity;drug structure;drug synthesis;EC50;human;IC50;minimum inhibitory concentration;nonhuman;Parkinson disease;Review;chemical structure;chemistry;structure activity relation;synthesis;Agrochemicals;Anti-Bacterial Agents;Anti-Inflammatory Agents, Non-Steroidal;Antineoplastic Agents;Antiparasitic Agents;Enzyme Inhibitors;Molecular Structure;Purinergic P1 Receptor Antagonists;Pyrimidines;Structure-Activity Relationship
期刊:
MINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN:
1389-5575
年:
2018
卷:
18
期:
9
页码:
781-793
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21172091, 21372093]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
The triazolopyrimidine ring is a ubiquitous structural feature of many active compounds with diversified pharmacology efficacy. These structures have aroused our / researchers interests in the development of novel compounds with anticancer, anti-inflammatory, antibacterial, antifungal, and other activities. A large number of published literatures were reviewed during the last few decades. This review contains various pharmacological and agrochemical activities of triazolopyrimidine and it may be regarded as the lead compound for t...

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