期刊论文

Lu, Liang-Qiu;Xiao, Wen-Jing

英文

Nature Communications

2041-1723

2019

10

1

10.1038/s41467-019-10674-3

We are grateful to the National Science Foundation of China (No. 21822103, 21820102003, 21772052, 21772053 and 21572074), the Program of Introducing Talents of Discipline to Universities of China (111 Program, B17019), the Natural Science Foundation of Hubei Province (2017AHB047) and International Joint Research Center for Intelligent Biosensing Technology and Health for support of this research. Prof. Dr. Sanzhong Luo in Institute of Chemistry (CAS, Beijing) is sincerely acknowledged for helpful discussion about the enantio-and diastereodivergent cycloaddition of aminoalcohols with β,γ-unsaturated ketones and for providing their chiral primary amine catalysts.

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Catalytic asymmetric cycloadditions via transition-metal-containing dipolar intermediates are a powerful tool for synthesizing chiral heterocycles. However, within the field of palladium catalysis, compared with the well-developed normal electron-demand cycloadditions with electrophilic dipolarophiles, a general strategy for inverse electron-demand ones with nucleophilic dipolarophiles remains elusive, due to the inherent linear selectivity in the key palladium-catalyzed intermolecular allylations. Herein, based on the switched regioselectivity...