期刊论文

Yang, Guang-Zhong

英文

European Journal of Medicinal Chemistry

0223-5234

2012

47

1

206-213

10.1016/j.ejmech.2011.10.044

Central Colleges, South-Central University for Nationalities [ZZZ10006]

本校为其他机构

A series of pyrimido[5,4-c]quinoline-4-(3H)-one derivatives variously substituted at positions 2 and 3 were synthesized and evaluated for their in vitro antiproliferative activities against a panel of six human cancer cell lines. Biological evaluation revealed that the vast majority of derivatives exhibited moderate tumor growth inhibitory activities. In particular, compound 7e showed effective anti-tumor activity with broad-spectrum toward numerous cell lines and the most active member in this study. This derivative displaying significant acti...