Inverse stochastic resonance (ISR) is the phenomenon of the response of neuron to noise, which is opposite to the conventional stochastic resonance. In this paper, the ISR phenomena induced by Gaussian and non-Gaussian colored noises are studied in the cases of single Hodgkin–Huxley (HH) neuron and HH neural network, respectively. It is found that the mean firing rate of electrical activities depends on the Gaussian or non-Gaussian colored noises which can induce the phenomenon of ISR. The ISR phenomenon induced by Gaussian colored noise is mo...