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Design, synthesis and activity evaluation of pseudilin analogs against cyanobacteria as IspD inhibitors

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成果类型:
期刊论文
作者:
Wang, Jili;Wu, Wenhai;Zhou, Yaqing;Han, Mengying;Zhou, Xin;...
通讯作者:
Sun, Y;Zhang, AD
作者机构:
[Zhou, Yaqing; Wang, Jili; Sun, Yong; Sun, Y; Zhou, Xin; Wu, Wenhai] Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.
[Zhang, Aidong; Han, Mengying] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构:
[Zhang, AD ] C
[Sun, Y ] H
Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.
Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
Bioisosteric replacement;Pseudilin;Anti-cyanobacteria;Molecular docking;IspD;N -phenyl-5;o -hydroxyphenylpyrazole-3;carboxyamide
期刊:
Pesticide Biochemistry and Physiology
ISSN:
0048-3575
年:
2024
卷:
199
页码:
105769
基金类别:
CRediT authorship contribution statement Jili Wang: Conceptualization, Data curation, Formal analysis, acquisition, Writing – original draft, Writing – review & editing. Wenhai Wu: Data curation, Formal analysis, Methodology, Software. Yaqing Zhou: Data curation, Formal analysis. Mengying Han: Data curation, Formal analysis. Xin Zhou: Data curation, Formal analysis. Yong Sun: Conceptualization, Resources. Aidong Zhang: Conceptualization, Methodology, Resources, Writing – review & editing.
机构署名:
本校为通讯机构
院系归属:
化学学院
摘要:
The discovery of safe, effective, and selective chemical algicides is the stringent need for the algicides development, and it is also one of the effective routes to control cyanobacteria harmful algal blooms and to meet the higher requirements of environmental and ecological. In this work, a series of novel bromo-N-phenyl-5-ohydroxyphenylpyrazole-3-carboxyamides were rationally designed as pseudilin analogs by bioisosteric replacement and molecular hybridization strategies, in which the pyrrole unit of pseudilin was replaced with pyrazole and further combined with the dominant structural frag...

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