期刊论文

Wu, Jia-Wei

英文

Bioorganic & Medicinal Chemistry

0968-0896

2011

19

15

4608-4615

10.1016/j.bmc.2011.06.008

The research was supported in part by the National Basic Research Program of China (No. 2010CB126103 ) and the NSFC (Nos. 20925206 , 20932005 , and 20872045 ). The authors also acknowledge Dr. Z. X. Wang for critical discussions and reading of the manuscript.

本校为第一且通讯机构

The cytochrome bc1 complex (EC 1.10.2.2, bc1) is one of the most promising targets for new drugs and agricultural fungicides. Among the existing bc1 complex inhibitors specifically binding to the Qo site, oxazolidinedione derivatives have attracted great attention. With the aim to understand the substituent effects of oxazolidinedione derivatives on the inhibition activity against the bc1 complex, a series of new oxazolidinedione derivatives were designed, synthesized, and biologically evaluated. The further inhibitory kinetics studies against ...