期刊论文

Sun, Yan(elaine.sun@utah.edu);Stang, Peter J.(stang@chem.utah.edu);Sun, Yao(sunyaogbasp@ccnu.edu.cn)

英文

CHEMICAL SCIENCE

2041-6520

2023

14

11

2901-2909

10.1039/d2sc06936a

National Natural Science Foundation of China [22022404, 22074050]; National Natural Science Foundation of Hubei Province [2022CFA033]; Fundamental Research Funds for the Central Universities [CCNU22QN007]; Open Project Program of Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University [GKLBCN-202206-03]; Open Project Program of Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education [FS2202]; Open Project Program of Hubei Province Key Laboratory of Occupational Hazard Identification and Control; NIH [OHIC2022K02]; Wuhan University of Science and Technology; [R01-CA215157]

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Although metallacycle-based photosensitizers have attracted increasing attention in biomedicine, their clinical application has been hindered by their inherent dark toxicity and unsatisfactory phototherapeutic efficiency. Herein, we employ a π-expansion strategy for ruthenium acceptors to develop a series of Ru(ii) metallacycles (Ru1-Ru4), while simultaneously reducing dark toxicity and enhancing phototoxicity, thus obtaining a high phototoxicity index (PI). These metallacycles enable deep-tissue (∼7 mm) fluorescence imaging and reactive oxyg...