Identification of Anti-SNRPA as a Novel Serological Biomarker for Systemic Sclerosis Diagnosis

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成果类型：

期刊论文

作者：

Liu, Chenxi;Song, Guang;Yan, Songxin;He, Yangzhige;Hu, Chaojun;...

通讯作者：

Li, YZ;Zhu, H

作者机构：

[Yan, Songxin; Li, YZ; Liu, Chenxi; Li, Liubing; Li, Yongzhe; Wen, Xiaoting] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Clin Lab, Beijing 100730, Peoples R China.

[Liu, Chenxi] Sichuan Univ, West China Univ Hosp 2, Dept Clin Lab, Chengdu 610041, Peoples R China.

[Song, Guang] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.

[Song, Guang; Zhu, Heng; Zhu, H] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA.

[He, Yangzhige] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Cent Res Lab, Beijing 100730, Peoples R China.

通讯机构：

[Li, YZ ] C

[Zhu, H ] J

Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Clin Lab, Beijing 100730, Peoples R China.

Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA.

语种：

英文

关键词：

HuProt array;systemic sclerosis;and biomarkers

期刊：

JOURNAL OF PROTEOME RESEARCH

ISSN：

1535-3893

年：

2023

卷：

期：

页码：

3254-3263

DOI：

10.1021/acs.jproteome.3c00268

基金类别：

National Key Research and Development Program of China [2018YFE0207300]; Beijing Natural Science Foundation [M23008]; National High Level Hospital Clinical Research Funding [2022-PUMCH-B-124]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Systemic sclerosis (SSc) is a systemic autoimmune disorder that leads to vasculopathy and tissue fibrosis. A lack of reliable biomarkers has been a challenge for clinical diagnosis of the disease. We employed a protein array-based approach to identify and validate SSc-specific autoantibodies. Phase I involved profiled autoimmunity using human proteome microarray (HuProt arrays) with 90 serum samples: 40 patients with SSc, 30 patients diagnosed with autoimmune diseases, and 20 healthy subjects. In Phase II, we constructed a focused array with candidates identified antigens and used this to prof...

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Identification of Anti-SNRPA as a Novel Serological Biomarker for Systemic Sclerosis Diagnosis

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