The invention and discovery of environment-friendly agrochemicals with a novel structure and reacting target is a interesting challenges to crop protection chemistry.A systematic study for the rational design of a novel effective inhibitor of pyruvate dehydrogenase complex (PDHc) as herbicide or fungicide has been carried out in our laboratory.Here we report the progresses in research and development of PDHc inhibitors as agrochemicals including two topics: 1,1-(substituted phenoxyacetoxy)alkylphosphonates were successfully found to be effe...