Efficient synthesis of dihydropyrazoles by halocyclization of β,γ-unsaturated hydrazones
作者：
Hu, Xiao-Qiang;Chen, Jia-Rong* ;Wei, Qiang;Liu, Feng-Lei;Deng, Qiao-Hui;...
期刊：
European Journal of Organic Chemistry ,2014年2014(15):3082-3086 ISSN：1434-193X
通讯作者：
Chen, Jia-Rong
作者机构：
[Liu, Feng-Lei; Deng, Qiao-Hui; Wei, Qiang; Xiao, Wen-Jing; Chen, Jia-Rong; Hu, Xiao-Qiang; Zou, You-Quan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China.;[Chen, Jia-Rong] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Bromine;Cyclization;Hydrazones;Nitrogen heterocycles;Synthetic methods
摘要：
An efficient halocyclization of β,γ-unsaturated hydrazones with N-bromosuccinimide was developed without the addition of any additives under mild reaction conditions to provide facile access to biologically important 4,5-dihydropyrazoles. Under the optimized conditions, a variety of highly substituted 4,5-dihydropyrazole derivatives were obtained in generally good yields. Moreover, this reaction can be further applied to the synthesis of pyrazoles in a one-pot fashion. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种：
英文
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Enantioselective organocatalytic oxa-Michael addition of oximes to β-CF3 -β-disubstituted nitroalkenes: Efficient synthesis of β-amino-α-trifluoromethyl alcohols
作者：
Liu, Feng-Lei;Chen, Jia-Rong* ;Feng, Bin;Hu, Xiao-Qiang;Ye, Li-Hua;...
期刊：
Organic & Biomolecular Chemistry ,2014年12(7):1057-1060 ISSN：1477-0520
通讯作者：
Chen, Jia-Rong
作者机构：
[Feng, Bin; Lu, Liang-Qiu; Liu, Feng-Lei; Ye, Li-Hua; Xiao, Wen-Jing; Chen, Jia-Rong; Hu, Xiao-Qiang] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Feng, Bin; Lu, Liang-Qiu; Liu, Feng-Lei; Ye, Li-Hua; Xiao, Wen-Jing; Chen, Jia-Rong; Hu, Xiao-Qiang] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin, Peoples R China.;[Chen, Jia-Rong] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
An enantioselective oxa-Michael addition of oximes to beta-CF3-beta-disubstituted nitroalkenes catalyzed by a chiral bifunctional cinchona alkaloid-based thiourea has been developed. A variety of trifluoromethylated oxime ethers possessing a tetrasubstituted carbon stereocenter were obtained in good yields with high enantioselectivities.
语种：
英文
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Organocatalytic asymmetric conjugate addition of 2-oxindole-3-carboxylate esters to 2-phthalimido acrylates: Efficient synthesis of Cγ-tetrasubstituted α-amino acid derivatives
作者：
Gao, Juan;Chen, Jia-Rong* ;Duan, Shu-Wen;Li, Tian-Ren;Lu, Liang-Qiu;...
期刊：
Asian Journal of Organic Chemistry ,2014年3(4):530-535 ISSN：2193-5807
通讯作者：
Chen, Jia-Rong
作者机构：
[Duan, Shu-Wen; Lu, Liang-Qiu; Li, Tian-Ren; Xiao, Wen-Jing; Chen, Jia-Rong; Gao, Juan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Duan, Shu-Wen; Lu, Liang-Qiu; Li, Tian-Ren; Xiao, Wen-Jing; Chen, Jia-Rong; Gao, Juan] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China.;[Chen, Jia-Rong] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
amino acids;conjugate addition;organocatalysis;2-oxindole-3-carboxylate esters;2-phthalimidoacrylates
摘要：
An organocatalytic asymmetric conjugate addition of 2-oxindole-3-carboxylate esters to 2-phthalimidoacrylates catalyzed by a quinine-derived thiourea is described. The reaction provides efficient access to a variety of quaternary oxindole based Cγ-tetrasubstituted α-amino acid derivatives in good to excellent yields (up to 96%) with moderate to good enantioselectivity (up to 90% ee). The opposite enantiomers of the products can also be obtained with comparable yields and stereoselectivity by simply using a quinidine-derived thiourea catalyst. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种：
英文
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Three-Component Coupling Reaction Triggered by Insertion of Arynes into the S=O Bond of DMSO
作者：
Liu, Feng-Lei;Chen, Jia-Rong* ;Zou, You-Quan;Wei, Qiang;Xiao, Wen-Jing
期刊：
Organic Letters ,2014年16(14):3768-3771 ISSN：1523-7060
通讯作者：
Chen, Jia-Rong
作者机构：
[Liu, Feng-Lei; Wei, Qiang; Xiao, Wen-Jing; Chen, Jia-Rong; Zou, You-Quan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 30072, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
An unprecedented three-component coupling reaction of arynes, α-bromo carbonyl compounds, and DMSO triggered by insertion of arynes into the S=O bond of DMSO has been developed. The reaction can generate a wide range of multisubstituted aryl methyl thioethers in good yields, wherein DMSO serves as both methylthiolation reagent and oxygen source. © 2014 American Chemical Society.
语种：
英文
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Visible-light-induced photocatalytic formyloxylation reactions of 3-bromooxindoles with water and DMF: The scope and mechanism
作者：
Zou, You-Quan* ;Guo, Wei;Liu, Feng-Lei;Lu, Liang-Qiu;Chen, Jia-Rong;...
期刊：
Green Chemistry ,2014年16(8):3787-3795 ISSN：1463-9262
通讯作者：
Zou, You-Quan
作者机构：
[Lu, Liang-Qiu; Guo, Wei; Liu, Feng-Lei; Xiao, Wen-Jing; Chen, Jia-Rong; Zou, You-Quan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China.;[Zou, You-Quan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Zou, You-Quan] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
The formyloxylation reaction of 3-bromooxindoles with water and N,N-dimethylformamide (DMF) has been developed in the presence of the photoredox catalyst fac-Ir(ppy)3 under irradiation of visible light at ambient temperature. The reaction provides a straightforward approach to pharmaceutically and synthetically useful 3-formyloxyoxindoles in high yields. The mechanism of this transformation was investigated by fluorescence quenching experiments, "on-off" switching of the light source, labeling experiments, mass spectral analyses and in situ IR experiments. This journal is © the Partner Organisations 2014.
语种：
英文
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Aerobic oxidative C-B bond cleavage of arylboronic acids mediated by methylhydrazines
作者：
Ding, Wei* ;Chen, Jia-Rong;Zou, You-Quan;Duan, Shu-Wen;Lu, Liang-Qiu;...
期刊：
Organic Chemistry Frontiers ,2014年1(2):151-154 ISSN：2052-4110
通讯作者：
Ding, Wei
作者机构：
[Duan, Shu-Wen; Lu, Liang-Qiu; Xiao, Wen-Jing; Chen, Jia-Rong; Ding, Wei; Zou, You-Quan] Cent China Normal Univ, Coll Chem, CCNU UOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Ding, Wei] Cent China Normal Univ, Coll Chem, CCNU UOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Ding, Wei] C;Cent China Normal Univ, Coll Chem, CCNU UOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
The aerobic oxidative C-B bond cleavage and ipso-hydroxylation of arylboronic acids mediated by methylhydrazine have been developed under metal-free conditions. This transformation affords structurally diverse phenols in good to excellent yields (26 examples, 71-99%). © 2015 Royal Society of Chemistry.
语种：
英文
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手性含氮杂环合成中的硫叶立德反应
作者：
陆良秋;阳青青;安静;肖文精
作者机构：
[陆良秋; 阳青青; 安静; 肖文精] 华中师范大学化学学院,武汉市珞喻路152号,430079
会议名称：
手性中国2014学术研讨会
会议时间：
2014-9-28
会议地点：
合肥
会议主办单位：
中国化学会
会议论文集名称：
手性中国2014学术研讨会论文集
摘要：
<正>许多具有生物活性的天然产物和药物分子都含有手性杂环骨架,尤其是手性氮杂环骨架,因此,研究含氮手性杂环的高效构建具有重要意义[1]。最近,我们发展了三种不同类型的硫叶立德参与的串联反应,分别是[4+1]环化/重排串联反应,[4+1]/[3+2]环加成串联反应和Michael加成/N-烷基化串联反应,并从简单易得的原料出发成功地合成一系列重要的手性含氮杂环化合物[2]。
语种：
中文
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De novo synthesis of imidazoles by visible-light-induced photocatalytic aerobic oxidation/[3+2] cycloaddition/aromatization cascade
作者：
Deng, Qiao-Hui;Zou, You-Quan;Lu, Liang-Qiu;Tang, Zi-Long;Chen, Jia-Rong* ;...
期刊：
CHEMISTRY-AN ASIAN JOURNAL ,2014年9(9):2432-2435 ISSN：1861-4728
通讯作者：
Chen, Jia-Rong
作者机构：
[Lu, Liang-Qiu; Deng, Qiao-Hui; Xiao, Wen-Jing; Chen, Jia-Rong; Zou, You-Quan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Lu, Liang-Qiu; Deng, Qiao-Hui; Xiao, Wen-Jing; Chen, Jia-Rong; Zou, You-Quan] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China.;[Tang, Zi-Long; Xiao, Wen-Jing] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China.;[Chen, Jia-Rong] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
cascade;cycloaddition;imidazoles;oxidation;photochemistry
摘要：
A visible-light-induced photocatalytic aerobic oxidation/[3+2] cycloaddition/aromatization cascade between secondary amines and isocyanides has been successfully developed. The reaction provides a general and efficient access to diversely substituted imidazoles and imidazo[1,5-a]quinoxalin-4(5 H)-ones in good yields under mild conditions. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种：
英文
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Visible-light-induced formal [3+2] cycloaddition for pyrrole synthesis under metal-free conditions
作者：
Xuan, Jun;Xia, Xu-Dong;Zeng, Ting-Ting;Feng, Zhu-Jia;Chen, Jia-Rong;...
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ,2014年53(22):5653-5656 ISSN：1433-7851
通讯作者：
Lu, Liang-Qiu
作者机构：
[Xia, Xu-Dong; Lu, Liang-Qiu; Feng, Zhu-Jia; Xiao, Wen-Jing; Chen, Jia-Rong; Xuan, Jun; Zeng, Ting-Ting] CCNU, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Xia, Xu-Dong; Lu, Liang-Qiu; Feng, Zhu-Jia; Xiao, Wen-Jing; Chen, Jia-Rong; Xuan, Jun; Zeng, Ting-Ting] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China.;[Xiao, Wen-Jing] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Beijing, Peoples R China.;[Lu, Liang-Qiu] CCNU, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lu, Liang-Qiu] C;CCNU, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
cycloaddition;dyes;heterocycles;photochemistry;synthetic methods
摘要：
A photocatalytic formal [3+2] cycloaddition of 2H-azirines with alkynes has been achieved under irradiation by visible light in the presence of organic dye photocatalysts. This transformation provides efficient access to highly functionalized pyrroles in good yields and has been applied to the synthesis of drug analogues. A primary trial of photocascade catalysis merging energy transfer and redox neutral reactions was shown to be successful. Photo(chemistry) op: A photocatalytic formal [3+2] cycloaddition of 2H-azirines with alkynes has been established under the irradiation of visible light in the presence of an organic dye. This transformation provides efficient access to highly functionalized pyrroles in good yields and has been applied to the formal synthesis of an inhibitor for HMG-CoA reductase. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种：
英文
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Visible-light-induced Ci-S bond activation: Facile access to 1,4-diketones from β-ketosulfones
作者：
Xuan, Jun;Feng, Zhu-Jia;Chen, Jia-Rong;Lu, Liang-Qiu* ;Xiao, Wen-Jing
期刊：
CHEMISTRY-A EUROPEAN JOURNAL ,2014年20(11):3045-3049 ISSN：0947-6539
通讯作者：
Lu, Liang-Qiu
作者机构：
[Lu, Liang-Qiu; Feng, Zhu-Jia; Xiao, Wen-Jing; Chen, Jia-Rong; Xuan, Jun] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China.;[Lu, Liang-Qiu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lu, Liang-Qiu] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
β-ketosulfones;C? S bond activation;1,4-diketones;radicals;visible light
摘要：
A novel method for the synthesis of 1,4-diketones from β-ketosulfones was developed by means of a visible light-induced CS bond activation process. Symmetrical and unsymmetrical 1,4-diketones can be easily prepared in moderate to good yields. A new and efficient method for the synthesis of 1,4-diketones from β-ketosulfones was developed by means of a visible-light-induced CS bond activation process (see scheme). Symmetrical and unsymmetrical 1,4-diketones can be easily prepared in moderate to good yields. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种：
英文
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Synthesis of CF3-Containing 3,3 '-Cyclopropyl Spirooxindoles by Sequential [3+2] Cycloaddition/Ring Contraction of Ylideneoxindoles with 2,2,2-Trifluorodiazoethane
作者：
Li, Tian-Ren;Duan, Shu-Wen;Ding, Wei;Liu, Yi-Yin;Chen, Jia-Rong;...
期刊：
JOURNAL OF ORGANIC CHEMISTRY ,2014年79(5):2296-2302 ISSN：0022-3263
通讯作者：
Lu, Liang-Qiu
作者机构：
[Lu, Liang-Qiu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China.;[Lu, Liang-Qiu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lu, Liang-Qiu] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
A [3 + 2] cycloaddition/ring contraction sequence of ylideneoxindoles with in situ-generated 2,2,2-trifluorodiazoethane without the use of any transition-metal catalyst has been developed. The reaction provides efficient access to biologically important and synthetically useful CF3-containing 3,3'-cyclopropyl spirooxindoles in high yield (74-99%) with high diastereoselectivity (>95:5 d.r.).
语种：
英文
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Direct sp(3) C-H acroleination of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with nucleophilic catalysis
作者：
Feng, Zhu-Jia;Xuan, Jun;Xia, Xu-Dong;Ding, Wei;Guo, Wei;...
期刊：
Organic & Biomolecular Chemistry ,2014年12(13):2037-2040 ISSN：1477-0520
通讯作者：
Lu, Liang-Qiu
作者机构：
[Xia, Xu-Dong; Lu, Liang-Qiu; Feng, Zhu-Jia; Guo, Wei; Xiao, Wen-Jing; Chen, Jia-Rong; Xuan, Jun; Ding, Wei; Zou, You-Quan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China.;[Lu, Liang-Qiu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lu, Liang-Qiu] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
acroleination;products;moderate
摘要：
Sequence catalysis merging photoredox catalysis (PC) and nucleophilic catalysis (NC) has been realized for the direct sp<sup>3</sup> C-H acroleination of N-aryl-tetrahydroisoquinoline (THIQ). The reaction was performed under very mild conditions and afforded products in 50-91% yields. A catalytic asymmetric variant was proved to be successful with moderate enantioselectivities (up to 83 : 17 er). ©2014 The Royal Society of Chemistry.
语种：
英文
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Photocatalytic aerobic oxidation/semipinacol rearrangement sequence: a concise route to the core of pseudoindoxyl alkaloids
作者：
Ding, Wei;Zhou, Quan-Quan;Xuan, Jun;Li, Tian-Ren;Lu, Liang-Qiu* ;...
期刊：
Tetrahedron Letters ,2014年55(33):4648-4652 ISSN：0040-4039
通讯作者：
Lu, Liang-Qiu
作者机构：
[Lu, Liang-Qiu; Li, Tian-Ren; Xiao, Wen-Jing; Zhou, Quan-Quan; Xuan, Jun; Ding, Wei] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300000, Peoples R China.;[Lu, Liang-Qiu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lu, Liang-Qiu] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Aerobic oxidation;2,2-Disubstituted indolin-3-one;Semipinacol rearrangement;Photocatalysis
摘要：
A visible light-induced photocatalytic aerobic oxidation/semipinacol rearrangement has been successfully developed. This methodology allows for efficient conversion of a wide range of indoles into the synthetically significant 2,2-disubstituted indolin-3-ones, the core structure of pseudoindoxyl alkaloids, under mild reaction conditions. (C) 2014 Published by Elsevier Ltd.
语种：
英文
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杂环合成中的硫叶立德反应
作者：
陆良秋;阳青青;安静;肖文精
作者机构：
[陆良秋; 阳青青; 安静; 肖文精] 华中师范大学化学学院 武汉430079
会议名称：
中国化学会第29届学术年会
会议时间：
2014-08-04
会议地点：
北京
会议主办单位：
中国化学会
会议论文集名称：
中国化学会全国第十一届有机合成化学学术研讨会论文集
关键词：
杂环;硫叶立德;串联反应
摘要：
许多具有生物活性的天然产物和药物分子都含有杂环骨架,因此,研究杂环的高效构建具有重要意义[1]。最近,我们发展了三种不同类型的串联反应,分别是[4+1]环化/重排串联反应,[4+1]/[3+2]环加成串联反应和Michael加成/N-烷基化串联反应,并从简单易得的原料出发成功地合成一系列重要的杂环化合物。
语种：
中文
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Metal-containing carbonyl ylides: Versatile reactants in catalytic enantioselective cascade reactions
作者：
Prof. Dr. Jia-Rong Chen;Xiao-Qiang Hu;Prof. Dr. Wen-Jing Xiao
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ,2014年53(16):4038-4040 ISSN：1433-7851
通讯作者：
Chen, J.-R.(chenjiarong@mail.ccnu.edu.cn)
作者机构：
[Xiao, Wen-Jing; Chen, Jia-Rong; Xiao-Qiang Hu] CCNU-OttawaU Joint Research Centre, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China;[Xiao, Wen-Jing; Chen, Jia-Rong; Xiao-Qiang Hu] Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China
通讯机构：
[Chen, J.-R.] C;CCNU-OttawaU Joint Research Centre, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
关键词：
asymmetric catalysis;cyclizations;heterocycles;synthetic methods;ylides
摘要：
New players in town: In situ generated transition-metal-containing carbonyl ylides are a unique class of reagents which have found wide applications in catalytic asymmetric cascade reactions. Recent advances in reaction design are likely to lead to more novel developments with these reactive species. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种：
英文
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Enantio- and Diastereoselective Synthesis of Spiro-epoxyoxindoles
作者：
Boucherif, Amina;Yang, Qing-Qing;Wang, Qiang;Chen, Jia-Rong;Lu, Liang-Qiu* ;...
期刊：
JOURNAL OF ORGANIC CHEMISTRY ,2014年79(9):3924-3929 ISSN：0022-3263
通讯作者：
Lu, Liang-Qiu
作者机构：
[Yang, Qing-Qing; Lu, Liang-Qiu; Xiao, Wen-Jing; Chen, Jia-Rong; Wang, Qiang; Boucherif, Amina] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China.;[Lu, Liang-Qiu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lu, Liang-Qiu] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
An asymmetric synthesis of epoxyoxindoles from isatins has been developed by employing chiral sulfur ylides generated in situ from camphor-derived sulfonium salts. This reaction allows an efficient access to enantioenriched spiro-epoxyoxindoles under mild reaction conditions, featuring high yields and excellent enantio- and diastereoselectivities.
语种：
英文
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Photocatalytic Generation of N-Centered Hydrazonyl Radicals: A Strategy for Hydroamination of β,γ-Unsaturated Hydrazones
作者：
Hu, Xiao-Qiang;Chen, Jia-Rong* ;Wei, Qiang;Liu, Feng-Lei;Deng, Qiao-Hui;...
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ,2014年53(45):12163-12167 ISSN：1433-7851
通讯作者：
Chen, Jia-Rong
作者机构：
[Liu, Feng-Lei; Deng, Qiao-Hui; Wei, Qiang; Beauchemin, Andre M.; Xiao, Wen-Jing; Chen, Jia-Rong; Hu, Xiao-Qiang] Cent China Normal Univ, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Liu, Feng-Lei; Deng, Qiao-Hui; Wei, Qiang; Beauchemin, Andre M.; Xiao, Wen-Jing; Chen, Jia-Rong; Hu, Xiao-Qiang] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China.;[Beauchemin, Andre M.] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada.;[Chen, Jia-Rong] Cent China Normal Univ, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;Cent China Normal Univ, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
heterocycles;hydrazones;photocatalysis;radicals;ruthenium
摘要：
A visible-light photocatalytic generation of N-centered hydrazonyl radicals has been accomplished for the first time. This approach allows efficient intramolecular addition of hydrazonyl radical to terminal alkenes, thus providing hydroamination and oxyamination products in good yields. Importantly, the protocol involves deprotonation of an N-H bond and photocatalytic oxidation to an N-centered radical, thus obviating the need to prepare photolabile amine precursors or the stoichiometric use of oxidizing reagents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种：
英文
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Enantioselective cascade Michael addition/cyclization reactions of 3-nitro-2H-chromenes with 3-isothiocyanato oxindoles: Efficient synthesis of functionalized polycyclic spirooxindoles
作者：
Tan, Fen;Lu, Liang-Qiu;Yang, Qing-Qing;Guo, Wei;Bian, Qiao;...
期刊：
CHEMISTRY-A EUROPEAN JOURNAL ,2014年20(12):3415-3420 ISSN：0947-6539
通讯作者：
Chen, Jia-Rong
作者机构：
[Yang, Qing-Qing; Bian, Qiao; Lu, Liang-Qiu; Guo, Wei; Tan, Fen; Xiao, Wen-Jing; Chen, Jia-Rong] CCNU, CCNU OttawaU Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Yang, Qing-Qing; Bian, Qiao; Lu, Liang-Qiu; Guo, Wei; Tan, Fen; Xiao, Wen-Jing; Chen, Jia-Rong] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China.;[Xiao, Wen-Jing] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.;[Chen, Jia-Rong] CCNU, CCNU OttawaU Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;CCNU, CCNU OttawaU Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
cascade reaction;heterocycles;indoles;Lewis acids;spirooxindoles
摘要：
An unprecedented Zn(OTf)2-catalyzed asymmetric Michael addition/cyclization cascade of 3-nitro-2H-chromenes with 3-isothiocyanato oxindoles has been disclosed. This transformation provides an efficient access to various synthetically important polycyclic spirooxindoles in a highly stereoselective manner under mild conditions (72-99 % yields, up to >95:5 d.r. and >99 % ee). The reaction leads to the formation of three consecutive stereocenters, including 1,3-nonadjacent tetrasubstituted carbon stereocenters, in a single operation. A bifunctional activation model of the chiral Zn(OTf)2/bis(oxazoline) complex was proposed based on control experiments, wherein the ZnII moiety serves as a Lewis acid and the N atom of the free NH group acts as a Lewis base by a hydrogen-bonding interaction. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种：
英文
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可见光促进的光氧化还原催化的三氟甲基化反应
作者：
曾婷婷;宣俊;陈加荣;陆良秋;肖文精
期刊：
影像科学与光化学 ,2014年32(5):415-432 ISSN：1674-0475
通讯作者：
Xiao, W.
作者机构：
[曾婷婷; 宣俊; 陈加荣; 陆良秋; 肖文精] 华中师范大学化学学院
通讯机构：
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei, China
关键词：
三氟甲基化;可见光催化;氧化淬灭;还原淬灭
摘要：
全氟烷基化反应,特别是三氟甲基化反应一直是有机化学领域的研究热点.近几年来,可见光促进的光氧化还原催化的有机化学反应,因其本身所固有的条件温和、绿色和环保等优点而倍受合成化学家的青睐.该方法学也被成功地应用于一系列三氟甲基化反应.本文主要按照三氟甲基源分类,总结了近年来可见光促进的光氧化还原催化的三氟甲基化反应的研究进展,并对其发展趋势进行了展望.
语种：
中文
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可见光催化的氧气氧化/半频哪醇重排串联反应
作者：
丁卫;陆良秋;肖文精
作者机构：
[丁卫; 陆良秋; 肖文精] 华中师范大学化学学院
会议名称：
中国化学会第29届学术年会
会议时间：
2014-08-04
会议地点：
北京
关键词：
氧气氧化;半频哪醇重排;可见光;2,2-二取代吲哚-3-酮
摘要：
可见光和氧气是两类具有环境友好、廉价易得等特质的可再生资源。因此,近些年来利用可见光催化技术和氧气甚至是空气来实现有机试剂的氧化反应,已经吸引了越来越多的化学工作者的研究兴趣。1基于课题组的前期工作,2我们设想将这类氧化反应应用于合成2,2-二取代吲哚-3-酮化合物。因此,我们发展了可见光催化的氧气氧化/半频哪醇重排串联反应。该反应从廉价易得的吲哚出发,在低功率LED灯(3瓦)的照射下高效、绿色地
语种：
中文
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