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Synthesis, Crystal Structure and Antiproliferative Activity of 2,2-Dimethyl-4-oxochroman-3-yl morpholine-4-carbodithioate

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成果类型:
期刊论文
作者:
Huang Wei;She Nengfang(佘能芳
通讯作者:
She Neng-Fang
作者机构:
[She Nengfang; Huang Wei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ China, Wuhan 430079, Peoples R China.
[Huang Wei] Jiangsu Simcere Pharmaceut Co Ltd, Jiangsu Key Lab Mol Targeted Antitumor Drug Res, Nanjing 210042, Jiangsu, Peoples R China.
[Huang Wei] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China.
通讯机构:
[She Neng-Fang] C
Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ China, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
chromanone;single-crystal X-ray diffraction;crystal structure;synthesis;antiproliferative activity
关键词(中文):
晶体结构;增殖活性;二甲基;氧代;硫代;单晶X-射线衍射;X-射线衍射分析;标题化合物
期刊:
Chinese Journal of Structural Chemistry
ISSN:
0254-5861
年:
2013
卷:
32
期:
9
页码:
1357-1361
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21272086]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2012T50475]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK2011086]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
The crystal structure of the new title compound 2,2-dimethyl-4-oxochroman- 3-ylmorpholine- 4-carbodithioate (C16H19NO 3S2, Mr = 337.44) has been prepared and determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group P-1 with a = 9.5518(7), b = 9.7172(7), c = 11.0220(8) Å, α{dot below} = 67.08(1), β{dot below} = 74.66(1), γ{dot below} = 61.31(1)°, V = 822.72(10) Å3, Z = 2, Dc = 1.362 g/cm3, F(000) = 356, μ = 0.092 mm -1, MoKa radiation (λ = 0.71073), R = 0.0515 and wR = 0.1389 for 2623 observed reflections ...

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