In this paper, the authors present a result on existence to the following singular biharmonic equation involving singular terms {δ2u-μ/|x|α μ = λg(x)μ+k(x)|μ|q-2 μ+|μ|2*-2 μ, x ∈ Ω, μ ∈D02,2(Ω), x ∈δΩ, where Ω is a bounded domain containing origin, Ω ( RN, N ≥ 5, 0 ≤ α, s 〈 4,2 〈 q 〈 2^*(s) = 2(N-s)/N-4}, and g(x), k(x) are nonnegative functions, the existence of solution is shown by variational method, the acquired function for the imbedding mapping D2,2(RN) → L2*(RN) plays an im...