期刊论文

Isaacs, Lyle;Briken, Volker（佘能芳）

英文

CHEMISTRY-A EUROPEAN JOURNAL

0947-6539

2016

22

43

15270-15279

10.1002/chem.201601796

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21272086, CHE-1404911]; Chinese Scholarship CouncilChina Scholarship Council; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [CA168365]; Czech Science FoundationGrant Agency of the Czech Republic [13-15576S]; Czech Ministry of EducationMinistry of Education, Youth & Sports - Czech Republic [LM2015051, LO1214]; program of Employment of Newly Graduated Doctors of Science for Scientific Excellence [CZ.1.07/2.3.00/30.0009]; European Social FundEuropean Social Fund (ESF); Czech Republic's state budget; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R01CA168365, R01CA168365, R01CA168365, R01CA168365, R01CA168365] Funding Source: NIH RePORTER; Direct For Mathematical & Physical ScienNational Science Foundation (NSF)NSF - Directorate for Mathematical & Physical Sciences (MPS) [1404911] Funding Source: National Science Foundation; Division Of ChemistryNational Science Foundation (NSF)NSF - Directorate for Mathematical & Physical Sciences (MPS) [1404911] Funding Source: National Science Foundation

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Molecular clip 1 remains monomeric in water and engages in host–guest recognition processes with suitable guests. We report the Kavalues for 32 1⋅guest complexes measured by1H NMR, UV/Vis, and fluorescence titrations. The cavity of 1 is shaped by aromatic surfaces of negative electrostatic potential and therefore displays high affinity and selectivity for planar and cationic aromatic guests that distinguishes it from CB[n] receptors that prefer aliphatic over aromatic guests. Electrostatic effects play a dominant role in the recognition process whereby ion–dipole interactions ...