作者：
Zhang, AD（张爱东）;Jaffrezic-Renault, N*;Wan, HL;Hou, YX;Chovelon, JM
期刊：
Materials Science and Engineering C: Materials for Biological Applications,2002年21(1-2):91-96 ISSN：0928-4931
通讯作者：
Jaffrezic-Renault, N
作者机构：
Ecole Cent Lyon, IFoS, UMR 5621, CNRS, F-69131 Ecully, France.;Cent China Normal Univ, Dept Chem, Wuhan 430079, Peoples R China.;Univ Lyon 1, LACE, UMR 5634, CNRS, F-69622 Villeurbanne, France.;[Jaffrezic-Renault, N] Ecole Cent Lyon, IFoS, UMR 5621, CNRS, 36 Ave Guy Collongue,BP 163, F-69131 Ecully, France.
通讯机构：
[Jaffrezic-Renault, N] E;Ecole Cent Lyon, IFoS, UMR 5621, CNRS, 36 Ave Guy Collongue,BP 163, F-69131 Ecully, France.
会议名称：
3rd Maghreb/Europe Meeting on Materials and Their Applications for Devices and Physical, Chemical and Biological Sensors
会议时间：
OCT 29-30, 2001
会议地点：
HAMMAMET, TUNISIA
会议主办单位：
Ecole Cent Lyon, IFoS, UMR 5621, CNRS, F-69131 Ecully, France.^Cent China Normal Univ, Dept Chem, Wuhan 430079, Peoples R China.^Univ Lyon 1, LACE, UMR 5634, CNRS, F-69622 Villeurbanne, France.
期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2001年123(12):2835-2838 ISSN：0002-7863
通讯作者：
Zhan, CG
作者机构：
[Zhan, CG] Cent China Normal Univ, Dept Chem, Wuhan 430070, Peoples R China.;Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA.;Pacific NW Natl Lab, Richland, WA 99352 USA.
通讯机构：
[Zhan, CG] C;Cent China Normal Univ, Dept Chem, Wuhan 430070, Peoples R China.
摘要：
Phosphodiesterases are clinical targets for a variety of biological disorders, because this superfamily of enzymes regulates the intracellular concentration of cyclic nucleotides that serve as the second messengers playing a critical role in a variety of physiological processes. Understanding the structure and mechanism of a phosphodiesterase will provide a solid basis for rational design of the more efficient therapeutics. Although a three-dimensional X-ray crystal structure of the catalytic domain of human phosphodiesterase 4B2B was recently reported, it is uncertain whether a critical bridging ligand in the active site is a water molecule or a hydroxide ion. The identity of this bridging ligand is theoretically determined by performing first-principles quantum chemical calculations on models of the active site. All the results obtained indicate that this critical bridging ligand in the active site of the reported X-ray crystal structure is a hydroxide ion, rather than a water molecule, expected to serve as the nucleophile to initialize the catalytic degradation of the intracellular second messengers.
摘要：
Aromatic-substituted derivatives of 1,3,2-diazaphospholidin-4-ones 2a-g were readily prepared front 1,3-diaryl glycinamides 1 by the reaction with hexaethylphosphoric triamide. Their chemical transformation was selectively effected with different thionation reagents to afford thionated products at the phosphorus atom to give 3a-g and at the carbonyl group to give 4a. An oxidation reaction at phosphorus to produce 5a was effected with 10% hydrogen peroxide. Preliminary bioassays revealed that some of the title compounds, 2a-g and 3a-g, possess selective herbicidal activity against rape. (C) 2001 John Wiley & Sons, Inc.
关键词：
surface-enhanced Raman spectra;anticancer model drugs;N-D-glucosamine;beta-naphthaldehyde and glycine
摘要：
Copper(II), zinc(II), cobalt(II) and cobalt(III) complexes of N-D-glucosamine β-naphthaldehyde (C<inf>17</inf>H<inf>19</inf>O<inf>6</inf>N, NG) and glycine were synthesized. The four novel metal complexes, Cu(II)C<inf>19</inf>H<inf>28</inf>O<inf>11</inf>N<inf>2</inf>(CuGNG), Zn(II)C<inf>19</inf>H<inf>24</inf>O<inf>9</inf>N<inf>2</inf>(ZnGNG), Co(II)C<inf>19</inf>H<inf>28</inf>O<inf>11</inf>N<inf>2</inf>(Co(II)GNG) and Co(III)C<inf>21</inf>H<inf>29</inf>O<inf>12</inf>N<inf>2</inf>(Co(III)GNG) were characterized by means of infrared (IR), electronic absorption spectroscopy and NMR etc. The surface-enhanced Raman spectra of the four complexes and their interaction with DNA were studied. By comparison of the surface-enhanced Raman spectra (SERS), the information of the four complexes' SER active sites and adsorption orientation were obtained. Combined with fluorescence spectra of Ethidium bromide (EthBr) DNA system, we concluded that none of the four complexes intercalate into DNA and that the presence of the glycine ligand lowered the anticancer activity of NG series complexes.
作者机构：
[Yang, HZ] Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China.;Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China.
通讯机构：
[Yang, HZ] C;Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China.
摘要：
Three novel amphiphilic phenylazonaphthalenes, namely, 6-(4-(4-octylphenylazo)naphthoxy)hexanoic acid, 6-(4-(4-dodecylphenylazo)naphthoxy)hexanoic acid, 6-(4-(4-hexadecylphenylazo)naphthoxy)hexanoic acid, were synthesized by diazo coupling, etherification and hydrolysis reactions successively. The kinetic studies of the trans-cis isomerization indicated that about 95% of the trans isomers of these compounds in chloroform solutions were transformed to cis isomers under the irradiation of near-ultraviolet light (380 ±30 nm) observed from UV-Vis spectra. In the dark condition, the cis isomers could reversibly convert to trans isomers following the first-order kinetics at the rates of 4.9 ×10<sup>-4</sup>, 5.7 ×10<sup>-4</sup>, 7.7 ×10<sup>-4</sup> S<sup>-1</sup>, respectively.
摘要：
Phase behavior of polybutadiene (PB) networks swollen in nematic liquid crystal p-ethoxybenzylidene-p-n-butylaniline (EBBA) strongly depends on whether there is surrounding EBBA: without the surrounding EBBA, EBBA in PB networks fails to form the nematic phase; in the presence of the surrounding EBBA, the nematic phase is formed inside the gels. The results suggest that a high order of molecular alignment in the surrounding nematic EBBA induces the formation of nematic phase inside the gels and the inducement effects overcome a high dilution effect of the impurity (PB) on the interaction between EBBA molecules.
摘要：
Membrane catalytic deprotonation of water (water splitting) has been studied on the base of a new model which suggests that water molecules are prepolarized by H<sup>+</sup>-affinited and OH<sup>-</sup>-affinited fixed charged groups of membrane before their dissociation is enhanced by electric field. Introducing some anion selective groups such as Mg(OH)<inf>2</inf>·xH<inf>2</inf>O or amine into a cation selective perfluorosulfonated membrane can initiate a dramatic water splitting effect and give rise to new high frequency peaks on the OH and OD stretching region of IR spectra. This supports the hypothesis that some water molecules were affected by the surrounding electrical field from the bipolar membrane-like structure. Perfluorocarboxylic membrane was also tested in a electrolytic cell and it causes H<sup>+</sup> ion fluxes much larger than Nafion-type membrane. We classify the effect as membrane catalytic deprotonation of carboxylic acid group.
作者机构：
[He, Liangnian; Zhuo, Renxi] Department of Chemistry, Wuhan University, Wuhan, China;[Cai Lei; Lu, Alhong] Institute of Organic Synthesis, Central China Normal University, Wuhan, China
摘要：
N,N′-diphenylurea reacted with phosphorus trichloride and phenyl dichlorophosphane giving the heterocyclic compounds 1 and 2 with a direct phosphorus-phosphorus bond (P-P bond), respectively. The new compounds were characterized by elementary analysis, NMR and IR spectra. The results of preliminary bioassay showed that these heterocycles possess selective herbicidal activity at 1.5 kg/hm2.
作者机构：
[Ding, MW; Tu, HY; Liu, ZJ] Institute of Organic Synthesis, Central China Normal University , Wuhan, China , 430070
通讯机构：
[Ding, MW] C;CENT CHINA NORMAL UNIV,INST ORGAN SYNTH,WUHAN 430070,PEOPLES R CHINA.
关键词：
Wittig reaction;Iminophosphoranes;Alkaloids
摘要：
Abstract A new facile synthesis of 2-amino-4H-imidazolin-4-ones 5 by using carbodiimides 3 which were obtained from aza-Wittig reaction of iminophos-phoranes 2 with isocyanate is described.
作者机构：
[Zeng Y.; 胡继明] Dept. of Anal.-Measurement Science, Wuhan University, 430012 Wuhan, China;[乐芝凤; 沈昊宇] Department of Chemistry, Huazhong Normal University, 430070 Wuhan, China;[陈建] Center of Analysis and Measurement, Zhongshan University, 510275 Guangzhou, China;Central China Normal University, China;Department of Chemistry, Wuhan University, China
通讯机构：
[Hu, J.] D;Dept. of Anal.-Measurement Science, , 430012 Wuhan, China
关键词：
D－氨基葡萄糖甘氨酸混配金属配合物;表面增强喇曼光谱
摘要：
研究了四种D-氨基葡萄糖甘氨酸混配金属配合物的表面增强喇曼光谱(SERS), 发现它们在银胶上的吸附方式基本相同, 因而SERS光谱也基本相似, 并用SERS光谱研究了它们与DNA的相互作用, 发现这四种化合物与DNA的作用能力有很大不同, Co (Ⅲ) GluG是值得进一步研究的可能抗癌药物。(图2表1参7)。
