作者机构：
[Quan, Fengjiao; Xu, Pengfei; Chen, Xiaolan; Shen, Wenjuan; He, Yun; Li, Jianfen] College of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan 430023, China;[Jia, Falong] College of Chemistry, Central China Normal University, Wuhan 430079, China;[Zhan, Guangming] School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
通讯机构：
[Falong Jia] C;College of Chemistry, Central China Normal University, Wuhan 430079, China
作者机构：
[Guo, Furong; Gao, Tingjuan] Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China;School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;[Li, Jiangshan] State Key Laboratory of Geomechanics and Geotechnical Engineering, Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan 430071, China;[Cao, Shiyu] Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China<&wdkj&>State Key Laboratory of Geomechanics and Geotechnical Engineering, Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan 430071, China;[Shi, Yanbiao; Zhang, Lizhi] Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China<&wdkj&>School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
通讯机构：
[Tingjuan Gao; Lizhi Zhang] K;Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China<&wdkj&>School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China<&wdkj&>Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China
期刊：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2025年326:125248 ISSN：1386-1425
通讯作者：
Zheng, Chunyang
作者机构：
[Mao, Yiqing; Wang, Dunjia; Dong, Chuanzong; Sun, Xuancheng; Li, Meiyin] Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, PR China;[Meng, Xianggao] College of Chemistry, Central China Normal University, Wuhan 430079, PR China;[Zheng, Chunyang] Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, PR China. Electronic address: cyzheng@hbnu.edu.cn
通讯机构：
[Zheng, Chunyang] H;Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, PR China. Electronic address:
摘要：
Based on the mixed ligand strategy, two new isostructural Cd(II) coordination polymers: {[Cd(3)(tcpa)(2)(bima)(DMF)]‧3DMF} (CP 1), {[Cd(3)(tcpa)(2)(bmima)(DMF)]‧3DMF} (CP 2) were synthesized by combining two flexible anthracene-based and a triphenylamine-based ligands with large π-electron-rich structure using a solvothermal method (H(3)tcpa=tris(4-carboxyphenyl)amine; bima=9,10-bis(1H-imidazole-1-yl)methyl)anthracene and bmima=9,10-bis((2-methyl-1H-imidazol-1-yl)methyl)anthracene). CP 1 and CP 2 show an unreported new 3D (3,14)-c net structure with the {4(30)·6(48)·8(13)}{4(3)}(4) topology. Both CPs could detect Cr(2)O(7)(2-), Nitroaromatic explosives 2,4,6-Trinitrophenol (TNP) and 2,4-dinitrophenol (DNP) through rapid fluorescence quenching response with high quenching efficiency Ksv and low LOD with 0.19μM (Cr(2)O(7)(2-)), 0.54 μM (TNP), 0.76 μM (DNP) for CP 1 and 0.28μM (Cr(2)O(7)(2-)), 0.23μM (TNP), 0.65μM (DNP) for CP 2, respectively. In addition, the mechanism of quenching Cr(2)O(7)(2-), TNP and DNP by CPs is proposed through experimental research and theoretical simulation. The quenching of Cr(2)O(7)(2-) by CPs is mainly competitive absorption (CA), while the quenching of TNP/DNP is achieved through the coexistence of competitive absorption CA, photo induced electron transfer (PET) and fluorescence resonance energy transfer (FRET). Moreover, we have been developed a portable smartphone-assisted on-site detection platform, which can perform semi-quantitative analysis of Cr(2)O(7)(2-) acconding to fluorescence color changes. This work constructed a ratiometric sensing platform for quickly and conveniently detection of Cr(2)O(7)(2-), TNP and DNP pollutants.
作者机构：
[Heng Yang; Jie Guo; Lu Xue; Lili Wen; Shuxin Ouyang] Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education;College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China.;College of Chemistry and Environmental Engineering, Wuhan Polytechnic University, Wuhan 430023, P. R. China.;[Yang Xia] Key Laboratory of Green Chemical Engineering Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430072, P. R. China;[Sónia A.C. Carabineiro] LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal
通讯机构：
[Lili Wen] E;Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education;College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China.
期刊：
Journal of Molecular Structure,2025年1322:140376 ISSN：0022-2860
通讯作者：
Chunyang Zheng
作者机构：
[Meiyin Li; Chuanzong Dong; Yiqing Mao; Xuancheng Sun; Dunjia Wang; Chunyang Zheng] Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, PR China;[Xianggao Meng] College of Chemistry, Central China Normal University, Wuhan 430079, PR China
通讯机构：
[Chunyang Zheng] H;Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, PR China
期刊：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2024年72(21):11900-11916 ISSN：0021-8561
通讯作者：
Cheng, Jing;Li, HB
作者机构：
[Cheng, Jing; Li, Guang; Xu, Weiwei; Li, Haibing; Li, HB; Xu, Yuan; Qu, Haonan] Cent China Normal Univ, Coll Chem, State Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Li, Ziheng] Cent China Normal Univ, Hubei Cent China Normal Univ Overseas Study Serv C, Wuhan 430079, Peoples R China.
通讯机构：
[Cheng, J; Li, HB ] C;Cent China Normal Univ, Coll Chem, State Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Food quality and safety are related to the health and safety of people, and food hazards are important influencing factors affecting food safety. It is strongly necessary to develop food safety rapid detection technology to ensure food safety. As a new detection technology, artificial nanochannel-based electrochemical and other methods have the advantages of being real-time, simple, and sensitive and are widely used in the detection of food hazards. In this paper, we review artificial nanochannel sensors as a new detection technology in food safety for different types of food hazards: biological hazards (bacteria, toxins, viruses) and chemical hazards (heavy metals, organic pollutants, food additives). At the same time, we critically discuss the advantages and disadvantages of artificial nanochannel sensor detection, as well as the restrictions and solutions of detection, and finally look forward to the challenges and development prospects of food safety detection technology based on the limitations of artificial nanochannel detection. We expect to provide a theoretical basis and inspiration for the development of rapid real-time detection technology for food hazards and the production of portable detection equipment in the future.
摘要：
Developing a desirable ethanol dehydrogenation process necessitates a highly efficient and selective catalyst with low cost. Herein, we show that the "complex active site" consisting of atomically dispersed Au atoms with the neighboring oxygen vacancies (Vo) and undercoordinated cation on oxide supports can be prepared and display unique catalytic properties for ethanol dehydrogenation. The "complex active site" Au-Vo-Zr3+ on Au1/ZrO2 exhibits the highest H2 production rate, with above 37,964 mol H2 per mol Au per hour (385 g H2 gAu-1 ${{\rm{g}}_{{\rm{Au}}}<^>{ - 1} }$ h-1) at 350 degrees C, which is 3.32, 2.94 and 15.0 times higher than Au1/CeO2, Au1/TiO2, and Au1/Al2O3, respectively. Combining experimental and theoretical studies, we demonstrate the structural sensitivity of these complex sites by assessing their selectivity and activity in ethanol dehydrogenation. Our study sheds new light on the design and development of cost-effective and highly efficient catalysts for ethanol dehydrogenation. Fundamentally, atomic-level catalyst design by colocalizing catalytically active metal atoms forming a structure-sensitive "complex site", is a crucial way to advance from heterogeneous catalysis to molecular catalysis. Our study advanced the understanding of the structure sensitivity of the active site in atomically dispersed catalysts. Au-oxygen vacancy-Zr3+ complex sites proved to be efficient and selective catalytic sites for ethanol dehydrogenation by facilitating ethanol dissociation/adsorption, ethoxy activation, and product desorption. image
期刊：
JOURNAL OF MEDICINAL CHEMISTRY,2024年67(15):12819-12834 ISSN：0022-2623
通讯作者：
Guo, J
作者机构：
[Wu, Ye-Hui; Ding, Dong; Luo, Meng-Qiang; Wang, En-Yang; Guo, J; Wen, Yu; Peng, Xiao-Qian; Guo, Jun; Zhou, Shi-Hao] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Guo, J ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Synthetic alpha-galactosylceramide (alpha GalCer) and its analogues as powerful agonists for natural killer T (NKT) cell manipulation have received significant attention in immunotherapy and adjuvant development. However, identifying new potent NKT cell agonists, especially those with Th1 selectivity that promote anticancer effects, remains a challenging task. In this work, we introduced a sulfonamide group into the acyl chain of alpha GalCer to form additional hydrogen bonds to intensify the glycolipid/CD1d interaction. Two compounds GCS-11 and GCS-12 demonstrated remarkable potency while exhibiting different cytokine induction patterns. Compared to alpha GalCer, the Th1-biased GCS-11 exhibited a 6-fold increase in IFN-gamma but not IL-4, while the Th1/2-balanced GCS-12 elicited 7- and 5-fold increase in IFN-gamma and IL-4, respectively, in vivo. These findings place them among the most potent NKT cell agonists, with superior antitumor effects. Therefore, hydrogen-bond-involved derivatization could be a powerful strategy to develop potent and polarized NKT cell agonists for various immunotherapies.
摘要：
As one of the most widely used disinfectants, active chlorine is synthesized predominantly through electrolysis of saturated sodium chloride solutions, an industrial process known as the chlor-alkali process, with high energy consumption. Seawater is an abundant source of chloride and thus an ideal alternative electrolyte. However, substantial challenges are to be addressed, notably the competing oxygen evolution reaction and progressive anode passivation due to the presence of rich cations in seawater. Here, we show durable and efficient active chlorine electrosynthesis directly from natural seawater with intrinsic turnover frequency and mass activity two orders of magnitude higher than the state of the art. The essential chemistry is an Fe-doped Ti4O7 anode that strengthens the electrophilicity of lattice oxygen to allow for site-selective chloride activation at remarkably lowered kinetic overpotentials relative to the oxygen evolution reaction, while also impeding the precipitation of alkaline earth metal cations on the Ti4O7 surface. A seawater splitting device with an integrated commercial silicon photovoltaic cell delivers an impressive active chlorine production rate of 3.15 mg min-1 for effective simulated ballast water disinfection. This work suggests the possibility to substantially improve the sustainability of the chlor-alkali process without compromising the synthetic performance for the mass production of disinfectants. This work shows a delicate titanium suboxide-based anode design for electrolysis of seawater, delivering selective production of active chlorine for on-site disinfection.
期刊：
Biosensors and Bioelectronics,2024年261:116470 ISSN：0956-5663
通讯作者：
Gong, JM
作者机构：
[Liu, Lijuan; Gong, JM; Meng, Mingxia; Gong, Jingming; Yao, Qingfeng; Cai, Zheng; Luo, Shuyue] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Gong, JM ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
摘要：
The aggravation of antibiotic resistance genes (ARGs) in the environment has posed a significant global health crisis. Accurate evaluation of ARGs levels in a facile manner is a pressing issue for environmental surveillance. Here, we demonstrate a unique dumbbell-shaped cascade nanozyme for visual/photoelectrochemical (PEC) dual-mode detection of ARGs. Gold nanoparticles (AuNPs) with tunable exposed facets are controllably anchored onto ZIF-8 dodecahedrons, exhibiting glucose oxidase (GOx)-like (ZIF-8@Au/G) and peroxidase (POD)-like (ZIF-8@Au/P) activities. Upon the occurrence of ARGs, an asymmetric cascade-amplified "dumbbell" configuration is spontaneously generated via target-induced DNA hybridization, comprising GOx-like ZIF-8@Au/G with capture DNA on one side and POD-like ZIF-8@Au/P with signal DNA on the opposite side. Such a cascade nano-system can efficiently oxidize colorless 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) into its green oxidation state and synergistically decompose H(2)O(2), realizing colorimetric/PEC dual-mode ARGs detection with a detection limit of 0.112nM. The applicability of the present bioassay is validated through measuring ARGs in real sludge samples. This work suggests the possibility to rationally design task-specific nanozymes and develop target-responsive nano-cascade assays for environmental monitoring.
作者机构：
[Peng, Hao; Xu, Hao; Hu, Yu-Ang; Zhu, CJ; Li, Zhi-Heng; Zhu, Cuiju] Cent China Normal Univ, Minist Educ, Coll Chem, State Key Lab Green Pesticide,Engn Res Ctr Photoen, Wuhan 430079, Peoples R China.;[Zhang, Panke; Pi, Chao] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China.;[Zhang, Panke; Pi, Chao] Zhengzhou Univ, Coll Chem, Key Lab Appl Chem Henan Univ, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450001, Peoples R China.
通讯机构：
[Zhu, CJ ] C;Cent China Normal Univ, Minist Educ, Coll Chem, State Key Lab Green Pesticide,Engn Res Ctr Photoen, Wuhan 430079, Peoples R China.
摘要：
Here, we report a nickel-catalyzed reductive C(sp3)-C(sp2) cross-coupling of monofluoroalkyl triflates with aryl halides, yielding a series of functionalized monofluoroalkylated arenes. This method is characterized by mild reaction conditions, a broad substrate scope, with excellent functional group compatibility. Facile follow-up transformations highlight its utility as an appealing tool in the synthesis of pharmaceutical derivatives. Here, we report a nickel-catalyzed reductive C(sp3)-C(sp2) cross-coupling of monofluoroalkyl triflates with aryl halides, yielding a series of functionalized monofluoroalkylated arenes.
摘要：
Catalytic asymmetric dearomatization reactions of alpha-unsubstituted beta-naphthols are very challenging due to the high energy barrier resulting from the loss of aromaticity. Herein, we describe an example of enantioselective catalytic dearomative spiroannulation with yne-allylic esters. The success of this reaction relied on the copper-catalyzed remote asymmetric strategy using yne-allylic esters as the bis-electrophilic reagents. This transformation features mild reaction conditions, broad functional group tolerance, and an extensive substrate scope, thereby facilitating the efficient construction of an array of enantioenriched naphthalene-2-one and spiroindolenine derivatives. Experimental studies and density functional theory calculations establish the reaction pathway and origin of stereoselectivity.
作者机构：
[Zhang, Yutian; Yin, Yashi; Wang, Wenjing; He, Yingsi; Gao, Yanru; Han, Heyou; Wang, WJ; Ren, Kejing] Huazhong Agr Univ, Coll Chem, Natl Key Lab Agr Microbiol, Wuhan 430070, Peoples R China.;[Han, Heyou; Hu, Can] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Peoples R China.;[Zhu, Chengzhou; Zhu, CZ] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, State Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Han, HY; Wang, WJ ; Han, HY ] H;[Zhu, CZ ] C;Huazhong Agr Univ, Coll Chem, Natl Key Lab Agr Microbiol, Wuhan 430070, Peoples R China.;Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Peoples R China.;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, State Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Citrus Huanglongbing (HLB) is known as the cancer of citrus, where Candidatus Liberibacter asiaticus (CLas) is the most prevalent strain causing HLB. In this study, we report a novel electrochemiluminescence (ECL) biosensor for the highly sensitive detection of the CLas outer membrane protein (Omp) gene by coupling rolling circle amplification (RCA) with a CRISPR/Cas12a-responsive smart DNA hydrogel. In the presence of the target, a large number of amplicons are generated through RCA. The amplicons activate the trans-cleavage activity of CRISPR/Cas12a through hybridizing with crRNA, triggering the response of smart DNA hydrogel to release the encapsulated AuAg nanoclusters (AuAg NCs) on the electrode and therefore leading to a decreased ECL signal. The ECL intensity change (I(0) - I) is positively correlated with the concentration of the target in the range 50 fM to 5 nM, with a limit of detection of 40 fM. The performance of the sensor has also been evaluated with 10 samples of live citrus leaves (five HLB negative and five HLB positive), and the result is in excellent agreement with the gold standard qPCR result. The sensing strategy has expanded the ECL versatility for detecting varying levels of dsDNA or ssDNA in plants with high sensitivity.
作者机构：
[Guan, Rui; Sun, Yao; Li, Junrong; Liu, Guorong] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Yan, Mingzhe] Huazhong Univ Sci & Technol, Wuhan Jinyintan Hosp, Tongji Med Coll, Wuhan 430023, Peoples R China.;[Cheng, Jing] Wuhan Univ Sci & Technol, Sch Publ Hlth, Wuhan 430072, Peoples R China.;[Zhan, Jianbo] Hubei Prov Ctr Dis Control & Prevent, Inst Hlth Inspect & Testing, Wuhan 430072, Peoples R China.;[Wuethrich, Alain; Trau, Matt; Wuethrich, A] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.
通讯机构：
[Wuethrich, A ] U;[Sun, Y ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.
摘要：
The molecular detection of multiple respiratory viruses provides evidence for the rational use of drugs and effective health management. Herein, we developed and tested the clinical performance of an electrohydrodynamic-driven nanobox-on-mirror platform (E-NoM) for the parallel, accurate, and sensitive detection of four respiratory viral antigens. The E-NoM platform uses gold-silver alloy nanoboxes as the core material with the deposition of a silver layer as a shell on the core surfaces to amplify and enable a reproducible Raman signal readout that facilitates accurate detection. Additionally, the E-NoM platform employs gold microelectrode arrays as the mirror with electrohydrodynamics to manipulate the fluid flow and enhance molecular interactions for an improved biosensing response. The presence of viral antigens binds the nanobox-based core-shell nanostructure on the gold microelectrode and creates the nanocavity with extremely strong "hot spots" to benefit sensitive analysis. Significantly, in a large clinical cohort with 227 patients, the designed E-NoM platform demonstrates the capability of screening respiratory infection with achieved clinical specificity, sensitivity, and accuracy of 100.0, 96.48, and 96.91%, respectively. It is anticipated that the E-NoM platform can find a position in clinical usage for respiratory disease diagnosis.
摘要：
Immune checkpoint inhibitors (ICIs) therapy targeting programmed cell death ligand 1 (PD-L1) and programmed death protein 1 (PD-1) had exhibited significant clinical benefits for cancer treatment such as triple negative breast cancer (TNBC). However, the relatively low anti-tumor immune response rate and ICIs drug resistance highlight the necessity of developing ICIs combination therapy strategies to improve the anti-tumor effect of immunotherapy. Herein, the immunomodulator epigallocatechin gallate palmitate (PEGCG) and the immunoadjuvant metformin (MET) self-assembled into tumor-targeted micelles via hydrogen bond and electrostatic interaction, which encapsulated the therapeutic agents doxorubicin (DOX)loaded PEGCG-MET micelles (PMD) and combined with ICIs (anti-PD-1 antibody) as therapeutic strategy to reduce the endogenous expression of PD-L1 and improve the tumor immunosuppressive microenvironment. The results presented that PMD integrated chemotherapy and immunotherapy to enhance antitumor efficacy in vitro and in vivo , compared with DOX or anti-PD-1 antibody for the therapy of TNBC. PMD micelles might be a potential candidate, which could remedy the shortcomings of antibody-based ICIs and provide synergistic effect to enhance the antitumor effects of ICIs in tumor therapy.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
摘要：
The abuse of biological and environmental related materials, such as pharmaceutical antibiotics, volatile organic chemicals and toxic ions has become a topical issue that draws the global attention. Thus, the exploration of effective methods for the rapid recognition of contaminants at low concentrations is critical for curtailing pollution and identifing environmental risks. Previous reports have shown that NH2-functionalized LCPs can serve as effective traps of hypochlorite owing to their rapid chemical reaction with hypochlorite. Herein, we strategically prepared a novel three-dimensional (3D) CP, [Co2(edda)(datrz)(H2O)2]& sdot;EtOH (Co-CP), using NH2decorated triazole ligand 3,5-diamino-1,2,4-triazole (datrz) combined with semirigid tetracarboxylic acid 5,5 '(ethane-1,2-diylbis(oxy)) diisophthalic acid (H4edda). The prepared Co-CP features a pcu topology with point symbol of {412.63}. This material exhibits high structural stability in acidic-basic aqueous solution of broad pH scope (1-11), which is favorable for fluorescence detection in aqueous medium. As expected, the open -NH2 sites within the framework endow this fluorescent CP with remarkable detectability towards hypochlorite in aqueous media. Furthermore, Co-CP also displays satisfactory fluorescence response for sensing nitrofuran antibiotics (NFT and NFZ) and acetylacetone with high sensitivity and selectivity along with great interference immunity. Through exhaustive theories calculations and experimental surveys, the possible mechanisms have also been thoroughly investigated. The CP-based multifunctional fluorescent switch designed in this work expands the application of such materials in biological and environmental related areas.
