JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION,2011年26(2):226-230 ISSN：1000-2413
[ Chang, Jiang ; Chen, Lei ; Hu, Sheng ; Ning, Congqin ; Lin, Kaili ] Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China;[ Zhou, Yue ] Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China;[Hu, Sheng ] Department of Physical Education, Huazhong Normal University, Wuhan 430079, China
[Chang, J] Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China.
[Deng, Wenjing; Yu, Longjiang; Ao, Yanxiao; Lv, Xueyuan; Yang, Qin; Wu, Mengying; Dai, Pengfei; Jin, Wenwen] a Department of Biotechnology, Institute of Resource Biology and Biotechnology , College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan , China;[Yu, Longjiang; Jin, Wenwen] c Key Laboratory of Molecular Biophysics , Ministry of Education , Wuhan , China , and;[Yu, Longjiang; Dai, Pengfei; Jin, Wenwen] d Wuhan Huashite Industrial Biotechnology Development Co. Ltd. , Wuhan Institute of Biotechnology , Wuhan , China;[Yang, Qin] b School of Physical Education and Sport , Central China Normal University , Wuhan , China
CONTEXT: Lepidium meyenii Walp. (Brassicaceae), most commonly known as "maca", has been used as a food or folk medicine to improve vitality in Peru. Previous research demonstrated that lipid-soluble extract from maca improved swimming endurance capacity. Macamides are considered the typical lipid-soluble markers for maca and proved to have several pharmacological properties, such as improving sexual performance and neuroprotective activies. OBJECTIVE: The present study investigates the effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice. MATERIALS AND METHODS: The Balb/c mice were divided into seven groups: a control group, low-dose groups of N-benzyllinoleamide, N-benzyloleamide, and N-benzylpalmitamide, high-dose groups of these macamides. The macamides groups received the commercial products (12 and 40 mg/kg, ig), while the control group received vehicle for 21 d. On the 14th day, the mice were given the weight-loaded swimming test. On the 21st day, the mice were sacrificed immediately after 90 min swimming, and some biochemical parameters were measured. RESULTS AND DISCUSSION: Compared with the control group, exhaustive swimming time was significantly prolonged in high-dose group of N-benzyloleamide (p < 0.05); the levels of lactic acid (LD), blood ammonia (BA), and lactate dehydrogenase (LDH) were significantly decreased (p < 0.05), whereas the levels of liver glycogen (LG) and non-esterified fatty acid (NEFA) were significantly increased (p < 0.05) in high-dose group of N-benzyloleamide. The malondialdehyde (MDA) contents in the brain, muscle, and liver were significantly decreased (p < 0.05), whereas superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities in the brain, muscle, and liver were significantly increased in high-dose group of N-benzyloleamide (p < 0.05). CONCLUSION: The results indicate that N-benzyloleamide has pharmaceutical property against exercise-induced fatigue, and this effect can be explained by the modulated energy metabolism and improved antioxidant status.
[Bo, Jin; Schaffert, Jeffrey; Neill, Rebecca; Lee, Chi-Mei] Department of Psychology, Eastern Michigan University, Ypsilanti, MI 48197, United States;[Bo, Jin] School of Physical Education, Central China Normal University, Wu Han, PR China;[Bo, Jin] Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: email@example.com;[Schaffert, Jeffrey] Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States;[Neill, Rebecca] School of Medicine, Wayne State University, Detroit, MI 48202, United States
[Bo, Jin] Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address:
The current study examined the augmentation of error feedback on visuomotor adaptability in older adults with varying degrees of cognitive decline (assessed by the Montreal Cognitive Assessment; MoCA). Twenty-three participants performed a center-out computerized visuomotor adaptation task when the visual feedback of their hand movement error was presented in a regular (ratio = 1:1) or enhanced (ratio = 1:2) error feedback schedule. Results showed that older adults with lower scores on the MoCA had less adaptability than those with higher MoCA scores during the regular feedback schedule. However, participants demonstrated similar adaptability during the enhanced feedback schedule, regardless of their cognitive ability. Furthermore, individuals with lower MoCA scores showed larger after-effects in spatial control during the enhanced schedule compared to the regular schedule, whereas individuals with higher MoCA scores displayed the opposite pattern. Additional neuro-cognitive assessments revealed that spatial working memory and processing speed were positively related to motor adaptability during the regular scheduled but negatively related to adaptability during the enhanced schedule. We argue that individuals with mild cognitive decline employed different adaptation strategies when encountering enhanced visual feedback, suggesting older adults with mild cognitive impairment (MCI) may benefit from enhanced visual error feedback during sensorimotor adaptation. (C) 2016 Elsevier B.V. All rights reserved.
High-sensation seekers are prone to search for changing stimuli. Pre-attentive processes reveal the earliest cortical change detection in response to external stimulus changes. This study recorded the mismatch negativity (MMN) to intensity increments and decrements in a repetitive tone in high-and low-sensation seekers. It was found that the MMN amplitude for intensity-decrement deviants was larger in high-than low-sensation seekers. However, with regard to deviant-increment stimulation, the difference between the two groups was not significant. Consequently, the sensitivity of high-sensitivity seekers to pre-attentively detect a decrease in sound intensity is higher than that of low-sensation seekers.