N-取代苯甲酰基-N'-取代芳基硫脲的合成、晶体结构及生物活性
作者：
Peng Hao* ;He Hong-Wu
期刊：
有机化学 ,2007年27(4):502-506 ISSN：0253-2786
通讯作者：
Peng Hao
作者机构：
[He Hong-Wu; Peng Hao; Peng, H] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Peng Hao] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
酰基硫脲;3-(2-氯-4-三氟甲基苯氧基)苯甲酸;三氟羧草醚;晶体结构
摘要：
为了寻找新的高活性农药, 利用工业易得的三氟羧草醚及其中间体为起始原料, 设计合成了9个未见报道的N-取代苯甲酰基-N'-取代芳基硫脲化合物, 结构经IR, ~1H NMR, 元素分析确认. X射线衍射测定了化合物4b的晶体结构, 结果表明: 其分子属于三斜晶系, 空间群P-1, a=0.51588(19) nm, b=1.0766(4) nm, c=2.0596(8) nm, α=81.113(6)°, β=89.702(6)°, γ=78.131(6)°, V=1.1056(7) nm~3, Dc=1.445 Mg/m~3, Z=2, F(000)=492, μ=0.319 mm~(-1). 初步生物活性测试结果表明, 部分化合物具有较好的除草活性.
语种：
中文
展开
噻唑并嘧啶类化合物的合成研究进展
作者：
Liang Ying* ;He Hong-Wu
期刊：
有机化学 ,2007年27(2):166-174 ISSN：0253-2786
通讯作者：
Liang Ying
作者机构：
[He Hong-Wu; Liang Ying; Liang, Y] Cent China Normal Univ, Inst Pesticide Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Liang Ying] C;Cent China Normal Univ, Inst Pesticide Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
噻唑并嘧啶类化合物;合成;进展
摘要：
综述了在医药和农药领域具有广泛用途的噻唑并嘧啶类化合物近二十年来合成方法上的研究进展.结合本研究组在这一领域的工作介绍了噻唑并嘧啶类化合物的三种主要结构类型:噻唑并[3,2-a]嘧啶、噻唑并[4,5-d]嘧啶、噻唑并[5,4-d]嘧啶类化合物的相关合成方法及新进展.
语种：
中文
展开
大肠杆菌丙酮酸脱氢酶的克隆与表达优化
作者：
李艳;谭宏亮;何亚辉;袁均林;贺红武;...
期刊：
化学与生物工程 ,2007年24(10):28-31 ISSN：1672-5425
作者机构：
华中师范大学生命科学学院,湖北,武汉,430079;宜春学院医学院,江西,宜春,336000;华中师范大学化学学院,湖北,武汉,430079;[谭宏亮] 宜春学院;[杨旭; 贺红武; 袁均林; 何亚辉; 李中振; 丁书茂; 李艳] 华中师范大学
关键词：
大肠杆菌丙酮酸脱氢酶;克隆;表达优化
摘要：
为了在大肠杆菌中表达大肠杆菌丙酮酸脱氢酶,用PCR法从大肠杆菌总DNA中克隆了pdc基因,将其插入载体pGEX-KG后转化大肠杆菌BL21（DE3）,在IPTG的诱导下实现了表达。通过对表达条件的优化,在TB＋M9（1∶1）培养基中,33℃下使用终浓度0.5 g·L^-1的乳糖诱导4 h,重组大肠杆菌丙酮酸脱氢酶的表达量可占全菌蛋白的45%左右,比未优化前提高了约20%,同时大大降低了成本。
语种：
中文
展开
5-(4-Chlorophenoxy)-3,6-diphenyl-2-thioxo-2,3-dihydrothiazolo[4,5-d] pyrimidin-7(6H)-one 4-chlorophenol solvate
作者：
Liang, Ying;He, Hong-Wu*
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2007年63(1):o252-o253 ISSN：2053-2296
通讯作者：
He, Hong-Wu
作者机构：
[He, Hong-Wu; Liang, Ying] Cent China Normal Univ, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[He, Hong-Wu] C;Cent China Normal Univ, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
摘要：
In the title compound, C23H14ClN3O 2S2·C6H5ClO, the mean plane of the thiazolopyrimidine fragment makes dihedral angles of 64.26 (11), 77.70 (10) and 49.70 (18)° with the two attached phenyl rings and the 4-chlorophenoxy fragment. The crystal packing is stabilized by intermolecular O - H⋯O and intramolecular C - H⋯N hydrogen bonds, as well as by weak π-π stacking interactions. © 2007 International Union of Crystallography. All rights reserved.
语种：
英文
展开
Synthesis and structure of 2-substituted thieno[3 ',2 ': 5,6]pyrido[4,3-d]pyrimidin-4(3H)-one derivatives
作者：
Liu, Jian-Chao;He, Hong-Wu* ;Ding, Ming-Wu
期刊：
Helvetica Chimica Acta ,2007年90(5):999-1005 ISSN：0018-019X
通讯作者：
He, Hong-Wu
作者机构：
[He, Hong-Wu; Liu, Jian-Chao; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[He, Hong-Wu] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, Wuhan 430079, Peoples R China.
关键词：
Pyrido[4,3‐d]pyrimidin‐4(3H)‐one;Aza‐Wittig reaction
摘要：
A series of new 2-substituted 3-(4-chlorophenyl)-5,8,9- trimethylthieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-ones 8 were synthesized via an aza-Wittig reaction. Phosphoranylideneamino derivatives 6a or 6b reacted with 4-chlorophenyl isocyanate to give carbodiimide derivatives 7a or 7b, respectively, which were further treated with amines or phenols to give compounds 8 in the presence of a catalytic amount of EtONa or K 2CO3. The structure of 2-(4-chlorophenoxy)-3-(4- chlorophenyl)-5,8,9-trimethylthieno[3′,2′:5,6]pyrido[4,3-d] pyrimidin-4(3H)-one (8j) was comfirmed by X-ray analysis. © 2007 Verlag Helvetica Chimica Acta AG.
语种：
英文
展开
2-Chloro-5-{[5-(4-pyrid-yl)-1,3,4-oxa-diazol-2-yl]sulfanylmeth-yl}pyridine
作者：
Wei-Dong Wang;Qing-Yun Ren;Jia-Jia Wei;Hong-Wu He*
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2007年63(9):O3721-U2241 ISSN：2053-2296
通讯作者：
Hong-Wu He
作者机构：
[Hong-Wu He; Wei-Dong Wang; Qing-Yun Ren; Jia-Jia Wei] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Hong-Wu He] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.
摘要：
In the title compound, C13H9ClN4OS, the mean plane of the oxadiazole ring makes a dihedral angle of 6.34 (13)° with the mean plane of the pyridine ring. The dihedral angle between the chloropyridine ring and the oxadiazole ring is 74.43 (12)°, and the dihedral angle between the chloropyridine ring and the pyridine ring is 69.78 (11)°. The crystal packing is stabilized by inter- and intra-molecular C - H⋯N hydrogen bonds. © International Union of Crystallography 2007.
语种：
英文
展开
[2-（氟代苯氧）丙酰氧基]取代甲基膦酸二甲酯的合成与除草活性
作者：
李艳军;段吉平;贺红武
期刊：
应用化学 ,2007年24(5):596-598 ISSN：1000-0518
作者机构：
[李艳军; 段吉平; 贺红武] 华中师范大学化学学院
关键词：
膦酸酯;氟取代基;合成;除草活性
摘要：
通过2种2-（氟代苯氧）丙酸（Ⅰ）转化为相应的酰氯,再通过酰氯分别与4种α-羟基膦酸酯（Ⅱ）的缩合反应,将含氟基团引入到α-氧代烃基膦酸酯的骨架中,合成了8个新的α-[2-（氟取代苯氧）丙酰氧基]烃基膦酸酯,收率为20%～71%。经^1H NMR、IR和MS测试技术对所有化合物进行了结构表征。初步的生物活性测试表明,部分化合物对单、双子叶植物根的生长具有优异的抑制作用。质量浓度分别为100和10 mg/L时,化合物Ⅲe～Ⅲh对油菜根和稗草根的生长抑制率均超过93%。
语种：
中文
展开
MOLECULAR DOCKING OF SUBSTITUTED ALKYLPHOSPHONATES TO PYRUVATE DEHYDROGENASE
作者：
Hao peng;Hong-Wu He
作者机构：
[Hao peng; Hong-Wu He] Key Laboratory of Pesticide and Chemical Biology,Ministry of Education;[Hao peng; Hong-Wu He] College of Chemistry,Central China Normal University,Wuhan 430079,China
会议名称：
第17届国际磷化学学术会议(The 17th International Conference on Phosphorus Chemistry)
会议时间：
2007-4-15
会议地点：
厦门
会议主办单位：
中国化学会
会议论文集名称：
第17届国际磷化学学术会议(The 17th International Conference on Phosphorus Chemistry)论文集
语种：
英文
展开
丙酮酸脱氢酶测活方法比较研究
作者：
何亚辉;姜英;袁均林;贺红武;谭宏亮;...
期刊：
化学与生物工程 ,2006年23(8):27-30 ISSN：1672-5425
作者机构：
华中师范大学生命科学学院,湖北,武汉,430079;华中师范大学化学学院,湖北,武汉,430079;[谭宏亮; 杨旭; 贺红武; 袁均林; 何亚辉; 丁书茂; 姜英] 华中师范大学
关键词：
丙酮酸脱氢酶复合体;丙酮酸脱氢酶;活性;测活方法
摘要：
对目前几种丙酮酸脱氢酶测活的方法进行了比较研究.结果表明,在测定丙酮酸脱氢酶活性时, 2,6-二氯吲哚酚法灵敏度较高,是一种经济有效的好方法,铁***法不论从反应时间和现象变化上看都是最差的.但2,6-二氯吲哚酚法不能用于测定丙酮酸脱氢酶复合体活性,这时用辅酶A法较好,其灵敏度也比较高.
语种：
中文
展开
5-Methyl-2-(2-nitrophenyloxy)-3-p-tolyl-8,9,10,11-tetrahydrobenzo[4′, 5′]thieno-[3′,4′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-one
作者：
Chen, HL;He, HW*
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2006年62(1):o195-o197 ISSN：2053-2296
通讯作者：
He, HW
作者机构：
[He, HW; Chen, HL] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[He, HW] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
In the title compound, C27H23N4O 4S, the three fused heterocyclic rings are essentially coplanar. The crystal stacking is mainly due to jr-jr interactions and intermolecular C-H⋯O hydrogen-bonding interactions. ©, 2006 International Union of Crystallography Printed in Great Britain - all rights reserved.
语种：
英文
展开
(E)-3-Methylstilbene
作者：
Gao, Ling;Peng, Hao;He, Hong-Wu*
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2006年62(11):o5032-o5033 ISSN：2053-2296
通讯作者：
He, Hong-Wu
作者机构：
[He, Hong-Wu; Gao, Ling; Peng, Hao] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[He, Hong-Wu] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
In the title compound, C15H14, the two benzene rings and the C=C double bond are almost coplanar. In the crystal structure, molecules are linked by intermolecular C-H⋯ stacking interactions. © 2006 International Union of Crystallography All rights reserved.
语种：
英文
展开
A facile synthesis of 2-substituted thieno[3 ',2 '-5,6]-pyrido[4,3-d]pyrimidin-4(3H)-ones
作者：
Liu, Jian-Chao;He, Hong-Wu* ;Ren, Qing-Yun;Ding, Ming-Wu
期刊：
Journal of Heterocyclic Chemistry ,2006年43(3):803-806 ISSN：0022-152X
通讯作者：
He, Hong-Wu
作者机构：
[He, Hong-Wu; Ren, Qing-Yun; Liu, Jian-Chao; Ding, Ming-Wu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[He, Hong-Wu] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
The thienopyridine derivative 2, obtained from reaction of acetoacetic ester with 1 in the presence of tin tetrachloride, was treated with triphenylphosphine in hexachloroethane and Et3N to give iminophosphorane 3. Iminophosphorane 3 reacted with phenyl isocyanate to give carbodiimide 4, which was further treated with phenols or ethenol to produce 2-substituted 5,8,9-trimethyl-3-phenyl-thieno[3′,2′-5,6]pyrido[4,3- d]pyrimidin-4(3H)-ones 5 in presence of catalytic amount of K2CO 3 or EtONa. The structures of compounds 5 were confirmed by 1H NMR, IR, MS, and elemental analysis.
语种：
英文
展开
Dimethyl {1 -[2-(2-fluorophenoxy)acetoxy]-ethyl}phosphonate
作者：
Li, YJ* ;He, HW
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2006年62(4):o1593-o1594 ISSN：2053-2296
通讯作者：
Li, YJ
作者机构：
[Li, YJ] Wuhan Univ, Coll Chem Engn & Technol, Wuhan 430081, Peoples R China.;Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Li, YJ] W;Wuhan Univ, Coll Chem Engn & Technol, Wuhan 430081, Peoples R China.
摘要：
The crystal structure of the title compound, C12H 16FO6P, stabilized by intermolecular C-H⋯O hydrogen bonds. © 2006 International Union of Crystallography All rights reserved.
语种：
英文
展开
Facile Synthesis and Fungicidal Activities of O,O-dimethyl l-(substitutedpyrazole-4-carbonyloxy)Alkylphosphonates
作者：
梁英;贺红武
作者机构：
[梁英; 贺红武] Key Laboratory of Pesticide and Chemical Biology,Ministry of Education of China and College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China;[梁英; 贺红武] Key Laboratory of Pesticide and Chemical Biology,Ministry of Education of China and College of Chemistry,Central China Normal University, Wuhan 430079, P. R. China
会议名称：
第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会
会议时间：
2006-04
会议地点：
中国河南郑州
摘要：
<正>Pyrazole derivatives have attracted increasing attention because they exhibit wide and high activities as herbicides, fungicides, plant regulators and antiviral agents. A lot of new fungicides such
语种：
英文
展开
5-Benzylamino-6-phenyl-2-propylsulfanyl-thiazolo[5,4-d]pyrimidin-7(6H)-one
作者：
Huang, NY;Yuan, JZ;Xu, RJ;Ding, MW* ;He, HW
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2006年62(1):o88-o90 ISSN：2053-2296
通讯作者：
Ding, MW
作者机构：
[Ding, MW] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Dept Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Ding, MW] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.
摘要：
In the title compound, C21H20N4OS 2, the two rings of the fused thiazolo[5,4-d]pyrimidine system are almost coplanar. In the crystal structure, hydrogen-bonded tetramers are formed via N - H⋯N hydrogen bonds. © 2006 International Union of Crystallography Printed in Great Britain - all rights reserved.
语种：
英文
展开
应用氮杂Wittig反应合成鸟嘌呤衍生物
作者：
黄年玉;丁明武;贺红武
作者机构：
[黄年玉; 丁明武; 贺红武] 华中师范大学化学学院教育部农药与化学生物学重点实验室
会议名称：
第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会
会议时间：
2006-04
会议地点：
中国河南郑州
摘要：
<正>嘌呤在核酸化学和细胞生物学中具有基础性作用,利用嘌呤类衍生物作为治疗病毒性疾病的方法具有广阔的研究前景,早在十九世纪三十年代就开始应用嘌呤衍生物治疗恶性疾病。近年研究显示,取代的鸟嘌呤衍生物也同样具有潜在的生物活性和药理学活性。氮杂Wittig反应是一种将P=N转化为C=N的有效方法,便于合成多种含氮杂环,并已成为一种合成新型氮杂环及具有生理活性的天然杂环化合物的新方法。我们提出了应用氮杂W
语种：
中文
展开
Synthesis and Crystal Structure of O,O-Dimethyl-（2,4-Dich loro phenoxyacetoxy）-2-thiophenylmethyl phosphonate
作者：
王涛;贺红武;缪方明
作者机构：
[王涛; 贺红武; 缪方明] Key Laboratory of Pesticide and Chemical Biology,Ministry of Education of China and College of Chemistry,Central China Normal University, Wuhan 430079,Department of Chemistry, Yichun University, Yichun, 336000;[王涛; 贺红武; 缪方明] Institute of Crystal Chemistry,Tian Jin Normal University,Tianjin 300073,People’s Republic of China
会议名称：
第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会
会议时间：
2006-04
会议地点：
中国河南郑州
摘要：
<正>In the course of our research for new phosphonate derivatives with good biological activities, it has been shown that certain chlorophenoxy acetoxy alkyl phosphonates possess good herbicide activities and plant growth regulating activity.In order to find new phosphonates with better pesticide activity, the thiophene structural unit is introduced into their molecules, so O,O-Dimethyl-（2,4-Dichlorophenoxyacetoxy）-2-thiophenyl methyl phosphonate were synthesized by the reaction of 2,4-dichlorophenoxyacetic chloride with 1-hydroxy-2-thiophenyl methyl phosphonate
语种：
中文
展开
Synthesis and herbicidal activity of O,O-dialkyl phenoxyacetoxyalkylphosphonates containing fluorine
作者：
Chen, T;Shen, P;Li, YJ;He, HW*
期刊：
Journal of Fluorine Chemistry ,2006年127(2):291-295 ISSN：0022-1139
通讯作者：
He, HW
作者机构：
[He, HW; Shen, P; Chen, T; Li, YJ] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[He, HW] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
1-Hydroxyl alkylphosphonates;Fluorophenoxyacetic acid;Herbicidal activity;Synthesis
摘要：
A series of substituted phenoxyacetoxyalkylphosphonates bearing fluorine were designed and synthesized. All the new compounds were identified by elemental analysis, IR, H-1 NMR and MS and were tested for herbicidal activity in greenhouse at a rate of 1.5 kg/ha. The results of preliminary bioassay showed that fluorine moiety introduced to the core structure could help to improve the herbicidal activity, and compounds with a 3-trifluoromethyl in benzene ring exhibited higher inhibitory activity. (c) 2005 Elsevier B.V. All rights reserved.
语种：
英文
展开
6-(4-Fluorophenyl)-5-morpholino-3-phenyl-2-thioxo-2,3-dihydrothiazolo[4, 5-d]pyrimidin-7(6H)-one
作者：
Fan, Shuang;Liang, Ying;He, Hong-Wu*
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2006年62(12):o5731-o5733 ISSN：2053-2296
通讯作者：
He, Hong-Wu
作者机构：
[Fan, Shuang; He, Hong-Wu; Liang, Ying] Cent China Normal Univ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[He, Hong-Wu] C;Cent China Normal Univ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
In the structure of the title compound, C21H17FN 4O2S2, the fused thiazolopyrimidine ring system is nearly planar. The morpholine ring adopts a chair conformation. The crystal structure is stabilized by C-H⋯O hydrogen bonds and weak π-π stacking interactions. © 2006 International Union of Crystallography All rights reserved.
语种：
英文
展开
5-(4-chlorophenoxy)-3,6-diphenyl-2-thioxo-2,3-dihydrothiazolo[4,5-d] pyrimidin-7(6H)-one dichloromethane hemisolvate
作者：
Liang, Ying;Xu, Di-Fan;He, Hong-Wu*
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2006年62(11):o4868-o4869 ISSN：2053-2296
通讯作者：
He, Hong-Wu
作者机构：
[He, Hong-Wu; Liang, Ying; Xu, Di-Fan] Cent China Normal Univ, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[He, Hong-Wu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
In the title compound, C23H14ClN3O 3S2·0.5CH2Cl2, the mean plane of thiazolopyrimidine fragment makes dihedral angles of 65.8 (1)°, 80.1 (1)° and 55.5 (1)° with the two attached phenyl rings and the 4-chlorophenyloxy fragment. The crystal packing is stabilized by weak π-π stacking interactions. © 2006 International Union of Crystallography All rights reserved.
语种：
英文
展开
