作者机构：
[Zhang, Xian; Zhang, Ruiping] Shanxi Med Univ, Hosp 1, Radiol Dept, Taiyuan 030001, Peoples R China.;[Zhang, Xian; Dou, You; Sun, Yao; Li, Junrong] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticides, Wuhan 430079, Hubei, Peoples R China.;[Liu, Shuang] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China.;[Chen, Peiyao] Hubei Univ Technol, Natl Ctr Cellular Regulat & Mol Pharmaceut 111, Sch Food & Biol Engn, Minist Educ,Hubei Key Lab Ind Microbiol,Key Lab Fe, Wuhan 430068, Peoples R China.;[Wen, Yating] Shanxi Med Univ, Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Shanxi Bethune Hosp, Taiyuan 030001, Peoples R China.
通讯机构：
[Sun, Y ] C;[Zhang, RP ] S;Shanxi Med Univ, Hosp 1, Radiol Dept, Taiyuan 030001, Peoples R China.;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticides, Wuhan 430079, Hubei, Peoples R China.
摘要：
Although being applied as photosensitizers for photodynamic therapy, covalent organic frameworks (COFs) fail the precise fluorescence imaging in vivo and phototherapy in deep-tissue, due to short excitation/emission wavelengths. Herein, this work proposes the first example of NIR-II emissive and benzobisthiadiazole-based COF-980. Comparing to its ligands, the structure of COF-980 can more efficiently reducing the energy gap (Delta ES1-T1) between the excited state and the triplet state to enhance photodynamic therapy efficiency. Importantly, COF-980 demonstrates high photostability, good anti-diffusion property, superior reactive oxygen species (ROS) generation efficiency, promising imaging ability, and ROS production in deep tissue (approximate to 8 mm). Surprisingly, COF-980 combined with laser irradiation could trigger larger amount of intracellular ROS to high efficiently induce cancer cell death. Notably, COF-980 NPs precisely enable PDT guided by NIR-II fluorescence imaging that effectively inhibit the 4T1 tumor growth with negligible adverse effects. This study provides a universal approach to developing long-wavelength emissive COFs and exploits its applications for biomedicine. This pioneering NIR-II emissive COF-980 based on the benzobisthiadiazole scaffold has a series of better performance, demonstrating high photostability, good anti-diffusion property, superior reactive oxygen species generation efficiency, promising imaging ability, and ROS production in deep tissue (approximate to 8 mm), which are highly promising for bioimaging, photodynamic therapy, and other related biomedical fields. image
摘要：
在中国的制造业已建成了门类齐全、独立完整的产业体系的今天,制造业的重要性已经被越来越多的人所认识.作为制造业后备军培养基地的理工类高职院校,其自身有着与普通高校不同的特点.在理工类院校高职英语课程中实施模块式教学模式,不仅着重语言学习的实用性,也能引起学生跨学科、将文理相结合的学习兴趣,能很好地完成英语教学.目前对模块式教学的相关研究已很多,但如何在理工类高职院校开展主题英语课程的模块式教学研究并不多.本文从分析目前高职院校教学现状开始,分析了工学背景下理工类高职院校英语教学中实施模块化教学的意义,并以"Made in China"产业发展主题为例,详细阐述了课程实施的过程、内容、教学实例、教学策略与实施效果.
摘要：
The rice -crayfish field (i.e., RCF), a recently emerged rice cultivation pattern, has experienced remarkable growth in China over the last decade due to its significant socioeconomic advantages. However, the impacts of expanding RCF areas on the regional -scale ecological environment, particularly concerning methane (CH4) emissions, remain unclear. A major obstacle in addressing this knowledge gap is the absence of accurate and upto-date spatial distribution information on RCF across years. Here, we selected Jianghan Plain which has the largest RCF area in China as the study area. First, we developed a phenology-based identification algorithm using Landsat-7/8 satellite data, which considered the distinctive flooding signatures of RCF during the rice fallow periods, to identify RCF at the regional scale. Second, we employed the DeNitrification-DeComposition (DNDC) model to simulate the CH4 fluxes of various rice cropping systems, including RCF, rice monoculture (RM), ricerapeseed rotation (RR), and rice -wheat rotation (RW). Finally, the effects of RCF expansion during 2014-2019 on regional CH4 emissions were analyzed by comparing six scenarios that simulated the conversion of different rice cropping systems to RCF. Results showed the phenology-based algorithm performed well in extracting RCFs, achieving an overall accuracy >92 % for all years based on 1025 RCF and 2096 non-RCF validation samples. RCF generated the least CH4 flux, followed by RM, RR, and RW. Moreover, shifting from traditional rice cropping systems to RCF reduced CH4 emissions across all cases, with mitigation rates ranging from 4.82 % to 21.85 %, indicating RCF's substantial CH4 mitigation potential. These findings significantly improve our understanding of the ecological effects of RCF cultivation, which is critical for advancing land use planning and decision -making for sustainable agricultural development in China. Our presented evaluation method of integrating the remote sensing mapping algorithm and DNDC model can be easily generalized for other crop types in other regions.
作者机构：
[Guan, Rui; Sun, Yao; Li, Junrong; Liu, Guorong] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Yan, Mingzhe] Huazhong Univ Sci & Technol, Wuhan Jinyintan Hosp, Tongji Med Coll, Wuhan 430023, Peoples R China.;[Cheng, Jing] Wuhan Univ Sci & Technol, Sch Publ Hlth, Wuhan 430072, Peoples R China.;[Zhan, Jianbo] Hubei Prov Ctr Dis Control & Prevent, Inst Hlth Inspect & Testing, Wuhan 430072, Peoples R China.;[Wuethrich, Alain; Trau, Matt; Wuethrich, A] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.
通讯机构：
[Wuethrich, A ] U;[Sun, Y ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.
摘要：
The molecular detection of multiple respiratory viruses provides evidence for the rational use of drugs and effective health management. Herein, we developed and tested the clinical performance of an electrohydrodynamic-driven nanobox-on-mirror platform (E-NoM) for the parallel, accurate, and sensitive detection of four respiratory viral antigens. The E-NoM platform uses gold-silver alloy nanoboxes as the core material with the deposition of a silver layer as a shell on the core surfaces to amplify and enable a reproducible Raman signal readout that facilitates accurate detection. Additionally, the E-NoM platform employs gold microelectrode arrays as the mirror with electrohydrodynamics to manipulate the fluid flow and enhance molecular interactions for an improved biosensing response. The presence of viral antigens binds the nanobox-based core-shell nanostructure on the gold microelectrode and creates the nanocavity with extremely strong "hot spots" to benefit sensitive analysis. Significantly, in a large clinical cohort with 227 patients, the designed E-NoM platform demonstrates the capability of screening respiratory infection with achieved clinical specificity, sensitivity, and accuracy of 100.0, 96.48, and 96.91%, respectively. It is anticipated that the E-NoM platform can find a position in clinical usage for respiratory disease diagnosis.
期刊：
Science of The Total Environment,2024年922:171299 ISSN：0048-9697
通讯作者：
Mingqing Chen
作者机构：
[Xu, Ke; Jiang, Mengling; Wang, Shuxin; Han, Qi; Gao, Xiao; Du, Wanting; Wang, Yunyi] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China;[Chen, Mingqing] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China. Electronic address: chenmq@mail.ccnu.edu.cn
通讯机构：
[Mingqing Chen] H;Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China
摘要：
After aging in the environment, some nanoplastics will carry different charges and functional groups, thereby altering their toxicological effects. To evaluate the potential impact of aging of nanoplastics on the mammalian reproductive system, we exposed C57BL/6 male mice to a dose of 5mg/kg/d polystyrene nanoparticles (PS-NPs) with different functional groups (unmodified, carboxyl functionalized and amino functionalized) for 45days for this study. The results suggest that PS-NPs with different functional groups triggered oxidative stress, a decreased in the testis index, disruption of the outer wall of the seminiferous tubules, reduction in the number of spermatogonia cells and sperm counts, and an increased in sperm malformations. We performed GO and KEGG enrichment analysis on the differentially expressed proteins, and found they were mainly enriched in protein transport, RNA splicing and mTOR signaling. We confirmed that the PI3K-AKT-mTOR pathway is over activated, which may lead to reduction of spermatogonia stem cells by over differentiation. Strikingly, PS-NPs with functional group modifications are more toxic than those of unmodified polystyrene, and that PS-NPs with positively charged amino modifications are the most toxic. This study provides a new understanding for correctly evaluating the toxicological effects of plastic aging, and of the mechanism responsible for the reproductive toxicity caused by nanoplastics.
期刊：
Journal of Mathematical Analysis and Applications,2024年530(1):127636 ISSN：0022-247X
通讯作者：
Duan, R
作者机构：
[Duan, Ran; Chang, Shengchuang] Cent China Normal Univ, Sch Math & Stat, Hubei Key Lab Math Sci, Wuhan 430079, Peoples R China.
通讯机构：
[Duan, R ] C;Cent China Normal Univ, Sch Math & Stat, Hubei Key Lab Math Sci, Wuhan 430079, Peoples R China.
关键词：
Navier-Stokes-quantum equations;Rayleigh-Taylor instability;Hadamard sense
摘要：
Consider the linear and nonlinear Rayleigh-Taylor instability of the three-dimensional incompressible viscous Navier-Stokes-Quantum equations. For linearized problem, we determine the critical number.cprecisely. Then, we construct a linear growth solution by a modified variational method for k <.k(c). In addition, we show that.cis infinite for a special steady state <(rho)over bar>, which implies that quantum potential inhibit the instability instead of cutting it off. Based on this unstable linear solution and the priori estimates of the smooth solution to the perturbed problem, we establish the nonlinear instability of the density and the velocities in the sense of Hadamard. Compared with the related study on Navier-Stokes-Korteweg equations (Zhang (2022) [41]), we do not ask the capillarity coefficient to be small. (c) 2023 Elsevier Inc. All rights reserved.
关键词：
Compressible Navier-Stokes-Allen-Cahn system;Strong/classical solutions;Density-dependent viscosity;Large initial data
摘要：
This paper is concerned with a one-dimensional isentropic compressible Navier-Stokes-Allen-Cahn system with density-dependent viscosity, which models the motion of a mixture of two viscous compressible fluids. The case when the pressure $ p(\rho) = \rho^\gamma $, the viscosity $ \nu(\rho, \chi) = \rho^\alpha $, the interface thickness $ \delta(\rho) = \rho^\beta $ and the relaxation time function $ a(\rho, \chi, \chi_y) = \rho^\lambda $ is considered, where $ \rho $ and $ \chi $ are the density and the phase variable, respectively, and $ \gamma, \alpha, \beta, \lambda\in\mathbb{R} $ are parameters. Under some suitable assumptions on the parameters $ \gamma , \alpha, \beta, \lambda $ and the initial data, we prove the global existence and large-time behavior of nonvacuum strong and classical solutions to its Cauchy problem with large initial data. This appears to be the first global existence result on the Cauchy problem of the compressible Navier-Stokes-Allen-Cahn system with density-dependent viscosity and large data.
摘要：
This paper focuses on the existence of positive solutions for the following weakly coupled Schrödinger system with supercritical growth except at the origin: $ \begin{equation*} \left\{ \begin{array}{ll} -\Delta u_1 = \mu_1|u_{1}|^{p(r) - 2}u_1 + \beta|u_{2}|^{\frac{p(r)}{2}}|u_1|^{\frac{p(r)}{2}-2}u_{1}, & x\in B_1(0), \\ -\Delta u_2 = \mu_2|u_{2}|^{p(r) - 2}u_{2} + \beta|u_{1}|^{\frac{p(r)}{2}}|u_2|^{\frac{p(r)}{2}-2}u_{2}, & x\in B_1(0), \end{array} \right. \end{equation*} $ where $ B_1(0) $ is an unit ball $ {\mathbb{R}^N} $ with $ N\ge 3 $, $ \beta\in\mathbb{R} $ is a coupling constant, $ \mu_1,\mu_2\in {\mathbb R} $ are constants, $ p(r) = 2^* + r^{\alpha} $ with $ 2^* = \frac{2N}{N-2} $. Assuming that $ 0<{\alpha}<\min\{\frac{N}{2},N-2\} $, we apply concentration-compactness idea to show that the problem has a positive solution provided that $ \beta>0 $ if $ N\ge 5 $ and $ \beta\in(0,\beta_0]\cup[\beta_1,+\infty) $ for some positive constants $ \beta_0<\beta_1 $ if $ N = 3,4 $.
作者机构：
[Jian Feng Wang] School of Mathematics and Statistics, Shandong University of Technology, Zibo, P. R. China;[Xing Yu Lei; Shu Chao Li] Faculty of Mathematics and Statistics, Central China Normal University, Wuhan, P. R. China;[Zoran Stanić] Faculty of Mathematics, University of Belgrade, Belgrade, Serbia
通讯机构：
[Zoran Stanić] F;Faculty of Mathematics, University of Belgrade, Belgrade, Serbia
摘要：
The eccentricity matrix of a graph is obtained from the distance matrix by keeping the entries that are largest in their row or column, and replacing the remaining entries by zero. This matrix can be interpreted as an opposite to the adjacency matrix, which is on the contrary obtained from the distance matrix by keeping only the entries equal to 1. In the paper, we determine graphs having the second largest eigenvalue of eccentricity matrix less than 1.
作者机构：
[Huang, Jing] Guangzhou Univ, Sch Math & Informat Sci, Guangzhou, Peoples R China.;[Geng, Xianya] Anhui Univ Sci & Technol, Sch Math & Big Data, Huainan, Peoples R China.;[Zhou, Zihan] Cent China Normal Univ, Fac Math & Stat, Wuhan, Peoples R China.;[Zhou, Zihan] Cent China Normal Univ, Key Lab Nonlinear Anal & Applicat, Minist Educ, Wuhan, Peoples R China.
通讯机构：
[Zhou, ZH ] C;Cent China Normal Univ, Fac Math & Stat, Wuhan, Peoples R China.;Cent China Normal Univ, Key Lab Nonlinear Anal & Applicat, Minist Educ, Wuhan, Peoples R China.
摘要：
Identifying the graph with maximum or minimum spectral radius among a given class of graphs is a central problem in extremal spectral graph theory, known as the Brualdi- Solheid problem. For a graph G = (V-G, E-G), a subset S subset of V-G is called a maximum dissociation set if the induced subgraph G[S] does not contain P-3 as its subgraph, and the subset has maximum cardinality. The dissociation number of G is the number of vertices in a maximum dissociation set of G. In this paper, we first characterize all the connected graphs (resp. bipartite graphs, trees) having maximum spectral radius among connected graphs (resp. bipartite graphs, trees) with given order and dissociation number. Secondly, we show that the connected n-vertex graph with dissociation number phi having minimum spectral radius is a tree, where phi >= [2/3n] . Finally, we determine the graphs having minimum spectral radius with fixed order n and dissociation number phi is an element of {2, [2n/3], n - 1, n - 2}.(c) 2023 Elsevier B.V. All rights reserved.
作者机构：
[Zhou, Zihan; Li, Shuchao] Cent China Normal Univ, Fac Math & Stat, Wuhan 430079, Peoples R China.;[Zhou, Zihan; Li, Shuchao] Cent China Normal Univ, Key Lab Nonlinear Anal & Applicat, Minist Educ, Wuhan 430079, Peoples R China.;[Sun, Wanting] Shandong Univ, Data Sci Inst, Jinan 250100, Peoples R China.;[Wei, Wei] Shanghai Univ Engn Sci, Ctr Intelligent Comp & Appl Stat, Sch Math Phys & Stat, Shanghai 201620, Peoples R China.;[Zhang, Minjie; Zhang, MJ] Hubei Univ Arts & Sci, Sch Math & Stat, Xiangyang 441053, Peoples R China.
通讯机构：
[Zhang, MJ ] H;Hubei Univ Arts & Sci, Sch Math & Stat, Xiangyang 441053, Peoples R China.
关键词：
Signed mixed graph;Eisenstein matrix;Spectral radius
摘要：
A mixed graph M-G is obtained from a simple graph G by orienting an edge subset of G. A signed mixed graph is a mixed graph with arcs and edges signed + or -. The unit Eisenstein matrix (epsilon-matrix for short) of a signed mixed graph was recently introduced by Wissing and van Dam [32]. This novel matrix is indexed by the vertices of the signed mixed graph, and the entry corresponding to a positive arc from u to v is equal to omega = 1+i root 3/2 (and its symmetric entry is (omega) over bar = 1-i root 3/2); the entry corresponding to a negative arc is equal to -omega (and its symmetric entry is -(omega) over bar); the entry corresponding to a positive edge is equal to 1; the entry corresponding to a negative edge is equal to -1; and 0 otherwise. In this paper, we study the spectral properties of this epsilon-matrix. We characterize all the signed mixed graphs whose eigenvalues are contained in (-alpha, alpha) for alpha is an element of {root 2, root 3, root 2} .(c) 2023 Elsevier B.V. All rights reserved.
作者机构：
[Zhao, Qinqin] MianYang Teachers Coll, Deans Off, Mianyang, Peoples R China.;[Wang, Zheng; Bian, Yueran; Zeb, Irum; Zhang, Yan] Huazhong Univ Sci & Technol, Sch Educ, Wuhan, Peoples R China.;[Yang, Caihong] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Chen, Han] MianYang Teachers Coll, President Off, Mianyang, Peoples R China.;[Wang, Pu; Wang, P] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Rehabil Med, Shenzhen, Peoples R China.
通讯机构：
[Wang, P ] S;[Zhang, Y ] H;[Yang, CH ] C;Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;Sun Yat Sen Univ, Affiliated Hosp 7, Dept Rehabil Med, Shenzhen, Peoples R China.
关键词：
anxiety;anxiety without depression;cognitive control network;depression;fNIRS
摘要：
Anxiety is a common psychological disorder associated with other mental disorders, with depression being the most common comorbidity. Few studies have examined the neural mechanisms underlying anxiety after controlling for depression. This study aimed to explore whether there are differences in cortical activation in anxiety patients with different severities whose depression are normal. In the current study, depression levels were normal for 366 subjects-139 healthy subjects, 117 with mild anxiety, and 110 with major anxiety. Using the Hospital Anxiety and Depression Scale (HADS) and a verbal fluency task (VFT) to test subjects' anxiety and depression and cognitive function, respectively. A 53-channel guided near-infrared spectroscopic imaging technology (fNIRS) detected the concentration of oxyhemoglobin (oxy-Hb). Correlation analysis between anxiety severity and oxy-Hb concentration in the brain cortex was performed, as well as ANOVA analysis of oxy-Hb concentration among the three anxiety severity groups. The results showed that anxiety severity was significantly and negatively correlated with oxy-Hb concentrations in the left frontal eye field (lFEF) and in the right dorsolateral prefrontal area (rDLPFC). The oxy-Hb concentration in the lFEF and the rDLPFC were significantly lower in the major anxiety disorder group than that in the control group. This suggests that decreased cortical activity of the lFEF and rDLPFC may be neural markers of anxiety symptoms after controlling for depression. Anxiety symptoms without depression may be result from the dysfunction of the cognitive control network (CCN) which includes the lFEF and rDLPFC. Anxiety disorders often experience an internal sense of loss of control and often be associated with depression. This study aimed to explore the neural mechanisms underlying anxiety after controlling for depress ive symptoms. We found that decreased cortical activity of the lFEF and rDLPFC may be neural markers of anxiety symptoms after control depressive symptoms. Anxiety symptoms without depressive symptoms may be result from the dysfunction of cognitive control network including lFEF and rDLPFC.
