作者机构：
[He Junbo; Jin Chuanfei; Wang Chubei; He Hongwu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Inst Organ Synth, Wuhan 430079, Peoples R China.
通讯机构：
[Jin Chuanfei] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Inst Organ Synth, Wuhan 430079, Peoples R China.
摘要：
In the title molecule, C(21)H(13)F(6)N(3)O(2), the pyridine ring forms dihedral angles of 1.7 (1) and 5.2 (1)degrees with the two benzene rings. In the crystal structure, intermolecular N-H center dot center dot center dot O hydrogen bonds and pi center dot center dot center dot pi interactions [centroid-centroid distance of 3.628 (3) angstrom between aromatic rings] link molecules into stacks along the c axis. The two trifluoromethyl groups are each rotationally disordered between two orientations, with occupancy ratios of 0.58 (1):0.42 (1) and 0.55 (1):0.45 (1).
摘要：
Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC50 value of 19.64 μM, and compound 6 showed the lowest activity among all the tested molecules, with an IC50 value of 66.88 μM. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds.
作者机构：
[He, Hongwu; Peng, Hao; Tan, Xiaosong] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Tan, Xiaosong] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
In the title compound, C15H15Cl2O 7P, the benzene and furan rings form a dihedral angle of 73.54 (1)°. In the crystal, weak inter-molecular C - H⋯O hydrogen bonds link the mol-ecules into layers parallel to (100).
摘要：
Abstract Diacylhydrazines have been found as molting hormone analogs since RH‐5849 was reported as the first nonsteroidal ecdysone agonist in 1988. Optimizations on diacylhydrizines with benzoheterocycle containing oxygen were widely explored in recent years. In order to find novel compounds with high bioactivity, a series of mono‐ (I) and di‐acylhydrazine (II) derivatives containing furan were designed and synthesized. Their structures were confirmed by 1H NMR, IR, elemental analyses and single crystal X‐ray diffraction analyses (II7). The bioassay results showed that some of the mono‐acylhydrazine (I) derivatives exhibited good larvicidal activity against Culex pipiens pallens at 10 mg/L and better than those of di‐acylhydrazines (II). Generally, the anti‐tumor activity of di‐acylhydrazines (II) was better than that of mono‐acylhydrazines (I). A series of novel mono‐ and di‐acylhydrazines were designed by the replacement of part A with substituted phenyl furan. Their structures were confirmed by 1H NMR, IR, elemental analyses and single crystal X‐ray diffraction analyses. The bioassay results showed good larvicidal and anti‐tumor activity.
期刊：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS,2010年185(7):1491-1499 ISSN：1042-6507
作者机构：
[Difan Xu; Hongwu He] The Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei, PR China
摘要：
A series of dialkyl [(5-ethoxycarbonyl-4-methyl-1,3-thiazol-2-ylamino)arylmethane] phosphonates was synthesized by the reaction of ethyl 2-amino-4-methylthiazole-5-carboxylate, with dialkyl phosphite and aromatic aldehydes using Mg(ClO4)2 as the catalyst. All new compounds were identified by elemental analysis, IR, 1H NMR, and 13C NMR spectra. O,O'-Dimethyl α-[(5-Ethoxycarbonyl-4-methyl-1,3-thiazol-2-ylamino)arylmethane] phosphonate was further analyzed by a single-crystal X-ray diffraction analysis. The result of a preliminary bioassay indicated that some compounds exhibit inhibition activities against Rhizoctonia solani and Botrytis cinereapers at a dosage of 100 mg/L. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
摘要：
Isothiocyanate 2, obtained from aza-Wittig reaction of iminophosphorane 1 with CS2, reacted with amine to give 2-thioxo-2,3,5,6,7,8-hexahydrobenzothieno[2,3-d]pyrimidin-4(1H)-ones 4 in the presence of sodium ethoxide. S-Alkylation of 4 produced 2-alkylthio-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-ones 5 in good yields.
