作者机构:
[Liang Ying; Yang Ziwen; He Haifeng] Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China.;[Liang Ying; He Hongwu; He Haifeng] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Liang Ying] H;Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China.
作者机构:
[H.W.HE] Key Laboratory of Pesticide & Chemical Biology(CCNU), Ministry of Education;College ofChemistry, Central China Normal University, Wuhan 430079;[H.W.HE] College ofChemistry, Central China Normal University, Wuhan 430079
摘要:
The invention and discovery of environment-friendly agrochemicals with a novel structure and reacting target is a interesting challenges to crop protection chemistry.A systematic study for the rational design of a novel effective inhibitor of pyruvate dehydrogenase complex (PDHc) as herbicide or fungicide has been carried out in our laboratory.Here we report the progresses in research and development of PDHc inhibitors as agrochemicals including two topics: 1,1-(substituted phenoxyacetoxy)alkylphosphonates were successfully found to be effective inhibitors of PDHc E1 from plants and showed potential utility as herbicide.Fields trials showed that some of high activity compounds could be as a environment-friendly herbicide applied to control weeds in lawn,wheat and maize field.2,Further exploration and research of new inhibitors of PDHc E1 possessing bactericidal or fungicidal activity based on the structure of PDHc E1 in the microorganism has been also carried out in our laboratory.Some of compounds were demonstrated to be effective inhibitors of PDHc E1 from E.coli and exhibited antifungal activity.
作者机构:
[He, Hongwu; Peng, Hao; Ning, Lihong] Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan 430079, China
通讯机构:
[He, H.] K;Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, China
作者机构:
Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education,College of Chemistry, Central China Normal University, China
会议名称:
Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (四届农药与环境安全会)
会议时间:
2012-09-15
会议地点:
北京
会议论文集名称:
Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regul
摘要:
@@ Due to the important role of herbicide in modern agriculture, it is essential to develop efficient herbicide with novel structures or modes of action to overcome herbicidal resistance. The pyruvate dehydrogenase complex (PDHc) is one of the most important oxidoreductase in higher plants. A systematic study for the rational design of herbicide as inhibitor of PDHc El was carried out in our laboratory.
期刊:
Magnetic Resonance in Chemistry,2012年50(9):646-650 ISSN:0749-1581
通讯作者:
He, Hongwu
作者机构:
[He, Hongwu; He, Junbo; Sun, Shannan; Cui, Yanfang; Xu, Guohua; Mo, Wenyan; Xu, Hui; Song, Jingjing; Ren, Qingyun] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[He, Hongwu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[He, Hongwu] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词:
1 H NMR;13 C NMR;HMBC;HSQC;NMR;pyrido[4,3-d]pyrimidine derivatives
摘要:
The complete 1H and 13C NMR assignments of four series pyrido[4,3-d]pyrimidine derivatives were achieved by combination of one and two-dimensional NMR experiments, and the NMR signals of these compounds were analyzed and compared. Copyright (c) 2012 John Wiley & Sons, Ltd.
作者机构:
[Liang, Ying; He, Hai-Feng; Yang, Zi-Wen] Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Science, Wuhan 430064, China;[He, Hong-Wu] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, China
通讯机构:
[Liang, Y.] H;Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Science, China
作者机构:
[He, Hongwu; Peng, Hao] Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan 430079, China
通讯机构:
[He, H.] K;Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, China
关键词:
data-to-parameter ratio = 10.5;disorder in main residue;mean σ(C-C) = 0.007 Å;R factor = 0.079;single-crystal X-ray study;T = 292 K;wR factor = 0.257
摘要:
In the title compound, C34H18Cl2F6O6, one terminal trifluoro-methyl and one entire 2-chloro-4-(trifluoro-meth-yl)phenyl group are disordered with refined occupancy ratios of 0.715 (11):0.285 (11) and 0.517 (5):0.429 (5), respectively. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into ribbons propagating along the a-axis direction.
摘要:
A series of novel 2-(substituted phenoxyacetoxy)alkyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one bearing fluorine 5a-n and fluorine free 5o-q were designed and synthesized. The results of bioassay showed that some of the target compounds exhibited excellent herbicidal activities to Abutilon theophrasti, Brassica juncea, Amaranthus retroflexus and Eclipta prostrata in post-emergence treatment at a dosage of 150 g ai/ha. It could be found that the type and position of fluorine-containing group as X or Y on benzene ring had a very important effect on herbicidal activity. Compound 5l 2-[(2-chloro-4-fluorophenoxy)acetoxyl](methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one showed notable herbicidal activity, with 100% inhibition against A. theophrasti and A. retroflexus: and compound 5m 2-(3-trifluoromethylphenoxyacetoxy)(methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one with 100% inhibition against A. theophrasti even at a dosage of 75 g ai/ha. Additional crop selectivity testing showed that compounds 5g 2-(3-trifluoromethylphenoxyacetoxy)(phenyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one and 5l are safe to rice, corn, cotton, rape and wheat. (C) 2012 Elsevier B.V. All rights reserved.