作者机构：
[Sun, Y] Yunyang Teachers Coll, Dept Chem, Danjiangkou 442700, Peoples R China.;Cent China Normal Univ, Coll Chem, Inst Organ Synth, Wuhan, Peoples R China.
摘要：
Abstract Double 2‐alkylthio‐5‐phenylmethylidene‐4H‐imidazol‐4‐ones 6 were synthesized by S‐alkylation of double 2‐thioxo‐5‐phenylmethylidene‐4‐imidazolidinone 5, which was obtained via cyclization of vinyl isothiocyanate 4 with ethylenediamine.
摘要：
The title compound 3-benzyl-5-cyclohexylamino-6-phenyI-3,6-dihydro-1,2,3-triazolo[4,5-d]pyrimidin-7-one (C23H24N6O, Mr = 400.48) has been synthesized by means of tandem aza-Wittig reaction, and its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/n with a = 6.5550(6), b - 10.3711(10), c = 31.265(3)(A), β = 93.827(2)° ,V = 2120.8(4) (A)3, Z = 4, Dc = 1.254 g/cm3, S = 1.025, μ(MoKa) = 0.081 mm-1, F(000) = 848, R = 0.0576 and wR = 0.1368. X-ray analysis reveals that all ring atoms in the triazolopyrimidinone moiety are almost coplanar and the cyclohexyl ring adopts a chair conformation.
摘要：
Bis-imidazolone condensed ring derivatives (4) under bar were synthesized by S-alkylation of bis-imidazolidinones (3) under bar, which were obtained via tandem aza-Wittig reaction of vinyliminophosphoranes (1) under bar, carbon disulfide and ethylenediamine.
作者机构：
[Yang, SJ; Fu, BQ; Ding, MW] Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China.
通讯机构：
[Ding, MW] C;Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China.
摘要：
2-Aryloxy-4(3H)-quinazolinones 5 were synthesized from cyclization of carbodiimides 2 with various phenols in presence of catalytic solid potassium carbonate in satisfactory yields.
摘要：
A series of new 6-alkylamino-3-alkylthio-1-phenyl-1H-pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives 5 and 6 have been rapidly synthesized by a novel solution-phase regioselective synthetic method. Treatment of pyrazole o-aminoester 1 with dibromotriphenylphosphorane gave iminophosphorane 2, which underwent a aza-Wittig reaction with phenyl ioscyanate to provide the carbodiimide 3. The latter intermediate reacted with alkylamines and regioselectively provided the 1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one derivatives 5 and 6, some of which exhibited good fungicidal activity.
摘要：
The carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates, reacted with secondary amines to give 2-dialkylamino-5,6,7,8-tetrahydro-benzothieno[2,3-d]pyrimidin-4(3H)-ones 6 in presence of catalytic EtO-Na+. Reactions of 4 with phenols or ROH in presence of catalytic K2CO3 or RO -Na+ gave 2-aryl(alkyl)oxy-5,6,7,8-tetrahydro- benzothieno[2,3-d]pyrimidin-4(3H)-ones 6 in satisfactory yields. The effects of the nucleophiles on cyclization have been investigated.
期刊：
Journal of Heterocyclic Chemistry,2004年41(3):393-397 ISSN：0022-152X
通讯作者：
Liu, ZJ
作者机构：
[Liu, ZJ] Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China.;NanHua Univ, Coll Chem & Chem Engineer, Hengyang 421001, Peoples R China.
通讯机构：
[Liu, ZJ] C;Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China.
摘要：
A series of new 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one Derivatives 5 has been designed and regio-selectively synthesized via a tandem aza-Wittig reaction. The structures of all compounds prepared have been confirmed by 1H NMR, IR, EI-MS spectroscopy and elemental analyses. The results of preliminary bioassay indicate that most compounds 5 possess an inhibition effect against Botrytis cinereapers and Pyricularia oryzae at the concentration of 50 mg/L.
期刊：
Chinese Journal of Structural Chemistry,2004年23(10):1133-1137+1091 ISSN：0254-5861
作者机构：
College of Chemistry, Central China Normal University, Wuhan 430079, China;College of Chemistry & Chemical Engineering, Nanhua University, Hengyang 421001, China
摘要：
The title compound (C25H20FN5OS) has been synthesized and its crystal structure was determined by X-ray analysis. The crystal belongs to the orthorhombic system, space group Pbca with a = 10.327(4), b = 20.307(7), c = 21.234(9)(A), α = 90, β = 90, γ = 90°, V = 4453(3) (A)3, Z = 8, Dc = 1.365 g/cm3, Mr = 457.52, μ = 0.182 mm-1, F(000) = 1904, the final R = 0.0600 and wR = 0.0932 for 3911obsered reflections with I≥2σ(I). In the title compound, the S(1), C(1), C(2), C(3), C(4), C(5), N(1), N(2), N(3), N(4), O(1) and N(5) atoms form a mean planeⅠroughly within the average deviation of 0.0207 (A). The dihedral angles between planesⅠandⅡ(C(19)-C(20)- C(21)-C(22)-C(23)-C(24)),Ⅲ(C(6)-C(7)-C(8)-C(9)-C(10)-C(11)) and Ⅳ(C(12)-C(13)-C(14)- C(15)-C(16)-C(17)-C(18)-F(1)) are 21.40, 84.00 and 75.88o, respectively.
