期刊：
JOURNAL OF MEDICINAL CHEMISTRY,2024年67(8):6822-6838 ISSN：0022-2623
通讯作者：
Guo, J
作者机构：
[Bian, Miao-Miao; Zhang, Ru-Yan; Cui, Hong-Ying; Ding, Dong; Guo, J; Wen, Yu; Guo, Jun; Zhou, Shi-Hao; Zou, Yong-Ke] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Guo, J ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Weak antigens represented by MUC1 are poorly immunogenic, which greatly constrains the development of relevant vaccines. Herein, we developed a multifunctional lipidated protein as a carrier, in which the TLR1/2 agonist Pam(3)CSK(4) was conjugated to the N-terminus of MUC1-loaded carrier protein BSA through pyridoxal 5'-phosphate-mediated transamination reaction. The resulting Pam(3)CSK(4)-BSA-MUC1 conjugate was subsequently incorporated into liposomes, which biomimics the membrane structure of tumor cells. The results indicated that this lipidated protein carrier significantly enhanced antigen uptake by APCs and obviously augmented the retention of the vaccine at the injection site. Compared with the BSA-MUC1 and BSA-MUC1 + Pam(3)CSK(4) groups, Pam(3)CSK(4)-BSA-MUC1 evoked 22- and 11-fold increases in MUC1-specific IgG titers. Importantly, Pam(3)CSK(4)-BSA-MUC1 elicited robust cellular immunity and significantly inhibited tumor growth. This is the first time that lipidated protein was constructed to enhance antigen immunogenicity, and this universal carrier platform exhibits promise for utilization in various vaccines, holding the potential for further clinical application.
作者：
Liang, Ruxia;Zhang, Qian;Wang, Jianqiang;Lu, Jie
期刊：
IEEE Transactions on Neural Networks and Learning Systems,2024年35(3):3859-3873 ISSN：2162-237X
作者机构：
[Liang, Ruxia] Univ Technol Sydney, Australian Artificial Intelligence Inst AAII, Fac Engn & Informat Technol, Decis Syst & E Serv Intelligent DeSI Res Lab, Ultimo, NSW 2007, Australia.;[Liang, Ruxia] Cent China Normal Univ, Natl Engn Res Ctr Educ Big Data, Wuhan 430079, Peoples R China.;[Liang, Ruxia] Cent China Normal Univ, Fac Artificial Intelligence Educ, Wuhan 430079, Peoples R China.;[Lu, Jie; Zhang, Qian] Univ Technol Sydney, Australian Artificial Intelligence Inst, Faulty Engn & Informat Technol, Ultimo, NSW 2007, Australia.;[Wang, Jianqiang] Cent South Univ, Sch Business, Changsha 410083, Peoples R China.
关键词：
Recommender systems;Data models;Task analysis;Neural networks;Adaptation models;Social networking (online);Knowledge engineering;Cross-domain recommender systems (CDRSs);group recommender systems (GRSs);hierarchical attention network;recommender systems
摘要：
Many online services allow users to participate in various group activities such as online meeting or group buying, and thus need to provide user groups with services that they are interested. The group recommender systems (GRSs) emerge as required and provide personalized services for various online user groups. Data sparsity is an important issue in GRSs, since even fewer group-item interactions are observed. Moreover, the group and the group members have complex and mutual relationships with each other, which exacerbates the difficulty in modeling the preferences of both a group and its members for recommendation. The cross-domain recommender system (CDRS) is a solution to alleviate data sparsity and assist preference modeling by transferring knowledge from a source domain which has relatively dense data to another. The existing CDRSs are usually developed for individual users and cannot be directly applied for group recommendation. To alleviate the data sparsity issue in GRSs, we first study the cross-domain group recommendation problem and propose a hierarchical attention network-based cross-domain group recommendation method, called HAN-CDGR. HAN-CDGR takes the advantage of data from a source domain to benefit recommendation generation for both the individual users and groups in the target domain which has data sparsity and cannot generate accurate recommendation. In HAN-CDGR, a hierarchical attention network is constructed to learn and model individual and group preferences, with consideration of both group members' interactions and dynamic weights and the complex relationships between individuals and groups. Adversarial learning is used to effectively transfer knowledge from a source domain to the target domain. Extensive experiments, which demonstrate the effectiveness and superiority of our proposal, providing accurate recommendation for both individual users and groups, are conducted on three tasks.
期刊：
Journal of Materials Engineering and Performance,2024年33(5):2209-2218 ISSN：1059-9495
通讯作者：
Hua Tan
作者机构：
[Tan, Hua; Ren, Yongfei; Zhang, Haibo] Huazhong Univ Sci & Technol, Sch Mat Sci & Engn, State Key Lab Mat Proc & Die & Mould Technol, Wuhan 430074, Peoples R China.;[Tan, Hua; Ren, Yongfei; Zhang, Haibo] Guangdong HUST Ind Technol Res Inst, Dongguan 523808, Peoples R China.;[Tan, Hua; Ren, Yongfei; Zhang, Haibo] Shenzhen Res Inst Cent China Normal Univ, Shenzhen 518000, Peoples R China.;[Lu, Wenlong; Zang, Jiadong] Shenzhen Geekvape Technol Co Ltd, Shenzhen 518102, Peoples R China.;[Chen, Shenggui] Dongguan Univ Technol, Sch Mech Engn, Dongguan 523808, Peoples R China.
通讯机构：
[Hua Tan] S;School of Materials Science and Engineering, State Key Laboratory of Material Processing and Die and Mould Technology, Huazhong University of Science and Technology, Wuhan, China<&wdkj&>Guangdong HUST Industrial Technology Research Institute, Dongguan, China<&wdkj&>Shenzhen Research Institute of Central China Normal University, Shenzhen, China
摘要：
Porous silica ceramics are widely used as liquid transporters due to their desirable heat resistance, mechanical properties and chemical stability. In this work, we simulated the liquid absorbency and liquid permeation of samples with different pore sizes (such as 10, 20 and 40 mu m), and concluded that a large pore size is conducive to the liquid absorbency. Subsequently, porous silica ceramics were prepared through hot casting by using polymethyl methacrylate (PMMA) as a pore-forming agent. Experimental results showed that increasing the sintering temperature and reducing the heating rate would increase the pore size. Furthermore, the pore size increased with the increase of SiO2 and PMMA particle size, but inappropriate combination of particle size (such as 70 mu m PMMA and 20 mu m SiO2) resulted in an inhomogeneous pore structure. By testing the liquid absorbency of samples with different pore size (1.4, 6.8, 10.4, 14.2 and 20.4 mu m), we found that the liquid absorbency of the sample is correlated to the pore size. This study provides an experimental basis and theoretical guidance for the design and development of porous ceramics for liquid transport.
摘要：
Divergent thinking is assumed to benefit from releasing the constraint of existing knowledge (i.e. top-down control) and enriching free association (i.e. bottom-up processing). However, whether functional antagonism between top-down control-related and bottom-up processing-related brain structures is conducive to generating original ideas is largely unknown. This study was designed to investigate the effect of functional antagonism between the left inferior frontal gyrus and the right temporoparietal junction on divergent thinking performance. A within-subjects design was adopted for three experiments. A total of 114 participants performed divergent thinking tasks after receiving transcranial direct current stimulation over target regions. In particular, cathodal stimulation over the left inferior frontal gyrus and anodal stimulation over the right inferior frontal gyrus (Experiment 1), anodal stimulation over the right temporoparietal junction (Experiment 2), and both cathodal stimulation over the left inferior frontal gyrus and anodal stimulation over the right temporoparietal junction (Experiment 3) were manipulated. Compared with sham stimulation, the combination of hyperpolarization of the left inferior frontal gyrus and depolarization of the right temporoparietal junction comprehensively promoted the fluency, flexibility, and originality of divergent thinking without decreasing the rationality of generated ideas. Functional antagonism between the left inferior frontal gyrus (hyperpolarization) and right temporoparietal junction (depolarization) has a "1 + 1 > 2" superposition effect on divergent thinking.
通讯机构：
[Zhang, XS ] C;Cent China Normal Univ, Coll Urban & Environm Sci, Wuhan, Peoples R China.;Hubei Prov Key Lab Geog Proc Anal & Simulat, Wuhan, Peoples R China.
关键词：
ecosystem service trade-off/synergy;InVEST model;GeoSOS-FLUS model;multiscenario simulation;Jianghan Plain of China
摘要：
Disturbance from human activities has intensified the evolution of ecosystem structure in the Jianghan Plain of China, leading to intensified conflicts between ecosystem services. It is essential to clarify the trade-off synergies between ecosystem services in the Jianghan Plain of China to better coordinate the economic and social development and ecological protection of the region. Based on historical data and scenario predictions using the GeoSOS-FLUS model, the InVEST model was applied to five key ecosystem services: Carbon storage, crop production, habitat quality, soil conservation and water yield from 2000 to 2020. Spearman correlation analysis was used to explore the trade-off synergies between different ecosystem services in space and time. The results showed that arable land and water land areas are the most important land types in the Jianghan Plain of China. From 2000 to 2020, the increase in build-up land and water land areas was accompanied by a decrease in arable land, forest land and unused land, and an increase in forest land. The natural development scenario in 2035 continues this trend except forest land reduction, while the ecological protection scenario reverses this trend. From 2000 to 2020, crop production, water yield, and soil conservation increased in the Jianghan Plain of China, while carbon storage and habitat quality declined significantly, showing a spatial distribution pattern of higher in the northwest and lower in the southeast. The comprehensive ecosystem services simulated in 2035 showed a downward trend compared with 2020, and the ecological protection scenario has the smallest decrease. There is an overall synergistic relationship between the five ecosystem services in the Jianghan Plain of China, and the strongest synergistic relationship is between soil conservation and water yield. The spatiotemporal relationship between the ecosystems in the Jianghan Plain of China is dynamic and requires sustainable management. Thus, it is necessary to rationally utilize land resources and enhance the ecological functions of the area to minimize trade-offs based on scientific land and spatial planning to maximize synergy.
摘要：
In this report we propose two highly efficient ensemble algorithms incorporating the gPAV and the rotational pressure correction methods for computing Stokes-Darcy flow ensembles. All variables are fully decoupled including the three components of the velocity, leading to smaller linear systems to be solved at each time step. Moreover, all ensemble members share the same constant coefficient matrix for which the fast block CG method can be applied for computing the ensemble at one pass at significantly reduced computational cost. We prove the two new ensemble algorithms are unconditionally stable with respect to the modified energy without any constraints on the uncertain parameters or the time steps. We will provide details of implementation and discuss how to efficiently solve the corresponding linear systems. Numerical examples are presented to show the efficiency and effectiveness of the algorithms.
摘要：
Sediment yields in different slope sections on heterogeneous slopes. Note: (a) MTL/MDL; (b) MDL/MTL; (c) MTL/LBC; (d) LBC/MTL; (e) LBC/MDL; (f) MDL/LBC. MTL, MDL and LBC represent the simulated slopes filled with soils derived from nodular limestone, mud‐like limestone and limestone breccia. For heterogeneous slopes, upslopes were the primary contributors to slope deposits and accounted for a substantial portion of sediment yield. Besides, the parent materials of upslopes are a crucial factor influencing the source‐sink relationship. Abstract Understanding erosion, sediment sources and the spatial distribution along heterogeneous slopes is essential for soil and water conservation. In this study, soils derived from nodular limestone, mud‐like limestone and limestone breccia (abbreviated as SMTL, SMDL and SLBC, respectively) were utilized to establish artificial homogeneous and heterogeneous slopes. The homogeneous slopes MTL, MDL and LBC represent SMTL‐, SMDL‐ and SLBC‐filled‐ slopes, respectively. The heterogeneous slopes were abbreviated as MTL/MDL, MDL/LBC and LBC/MTL. Rare earth elements (REEs; lanthanide, cerium and ytterbium) were used to tag soils on the upper and lower slope sections to track sediment transport and deposition. The results showed that for homogeneous slopes, the LBC slope was the most severely eroded, followed by the MDL and MTL slopes. For heterogeneous slopes, the order of erosion was LBC/MTL > MTL/MDL > MDL/LBC. Upslope sections contributed a sizable portion of the total sediment yield, ranging from 51% to 79%. Over time, the difference in the sediment contribution between the upslope and downslope regions decreased and reached equilibrium. Runoff rates on heterogeneous slopes demonstrated an inverse function (R2 > 0.75) in contrast to a logarithmic distribution (R2 > 0.87) on homogeneous slopes. Heterogeneous slopes displayed minimal intersegment variation and the absence of a consistent ordering of the magnitude of hydraulic parameters. Conversely, the hydraulic parameters of homogeneous slopes were consistently ordered across the slope sections. For sediment transport, all slopes exhibited suspension‐dominated flow with percentages greater than 89%. However, the particle size distribution of the sediment of heterogeneous slopes exhibited greater diversity and complexity because of the coexistence of distinct soils. These findings underscore the importance of customized strategies for soil and water conservation in environments characterized by diverse soil parent materials.
期刊：
CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE,2024年36(5):e7941- ISSN：1532-0626
通讯作者：
He, H
作者机构：
[Wu, Tong; He, Hui; Zhao, Gang] Cent China Normal Univ, Fac Artificial Intelligence Educ, Wuhan, Peoples R China.;[Di, Bingbing] Henan Univ, Fac Educ, Kaifeng, Peoples R China.
通讯机构：
[He, H ] C;Cent China Normal Univ, Fac Artificial Intelligence Educ, Wuhan, Peoples R China.
摘要：
Sharing high-quality educational resources has become an effective way to promote educational equity. The traditional educational resource sharing platforms using centralized storage architecture have security issues. Recently, many studies use blockchain to achieve secure sharing of educational resources. However, the existing blockchain-based educational resource sharing schemes only use blockchain as a storage tool, and have issues such as low sharing efficiency, without considering copyright security, and lack of a trusted sharing environment, which prevents the large-scale sharing of educational resources. In response, we propose ERSChain, a novel blockchain-based educational resources sharing solution. First, we put forward a hybrid storage method that keeps the hash value of resource in the blockchain and stores the encrypted resource in the off-chain, which can alleviate the storage and computing pressure brought by massive educational resources while ensuring the integrity of resources. Second, we construct an efficient revocable ciphertext-policy attribute-based encryption algorithm to implement flexible access control and an outsourced decryption algorithm to achieve greater efficiency. Obtaining access to educational resources is possible when user's attributes meet the access policy and the user's identity does not exist in the revocation list. Third, we put forward a credit mechanism to adjust the user's credibility and a credit-based consensus mechanism to maintain the trusted sharing environment. Finally, security analysis and plentiful of experiments demonstrate that our proposed ERSChain achieves security assurance, has better applicability than similar works, and enables large-scale sharing of educational resources.
作者机构：
[Kong, Sheng; Yi, Beibei; Guo, R; Ma, Yujiao; Guo, Rui; Zhang, Guozhu; Du, Qianqian; Zhang, He; Zhang, GZ; Zheng, Jialian] Cent China Normal Univ CCNU, Int Joint Res Ctr Intelligent Biosensing Technol &, CCNU uOttawa Joint Res Ctr, Key Lab Pesticides & Chem Biol,Minist Educ,Coll Ch, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Guo, R ; Zhang, GZ] C;Cent China Normal Univ CCNU, Int Joint Res Ctr Intelligent Biosensing Technol &, CCNU uOttawa Joint Res Ctr, Key Lab Pesticides & Chem Biol,Minist Educ,Coll Ch, Wuhan 430079, Hubei, Peoples R China.
关键词：
Amines;Silylation;Copper catalysis;Hydrogen atom transfer;C−H activation
摘要：
The development of a general and selective method for alpha-C-(sp(3))-H silylation of feedstock amines has been a long-standing challenge. In this paper, we disclose a mild, general, practical, and highly regio- and diastereoselective alpha-C-(sp(3))-H silylation of various readily available acyclic, cyclic, and aromatic amines with silylboranes through a copper-catalyzed intramolecular 1,5-hydrogen atom transfer (HAT) strategy. The mild activation of 2-iodobenzamide to generate an aryl radical enabled by a ligand-coordinated silyl copper complex without additional heating or photoinduced conditions, as well as the intramolecular selective 1,5-HAT process to produce the crucial alpha-aminoalkyl radical species, is the key to the success of this chemistry. This silylation protocol has demonstrated its potential utility in the late-stage modification of structurally complex drugs and bioactive molecules. Therefore, it is expected that this method will find applications in synthetic chemistry and drug discovery.
作者机构：
[Qiu, Xiaofeng; Zheng, Juan; Zhu, Xiaoxiao; Zhang, Qian; Guo, Yanbing; Zhu, Yuhua; Chen, Wei; Zhang, Baojian; Guo, YB; Luo, Zhu; Li, Weihao; Pan, Chuanqi; Fang, Yarong; Wang, Jinlong] Cent China Normal Univ, Inst Environm & Appl Chem, Engn Res Ctr Photoenergy Utilizat Pollut Control &, Minist Educ,Coll Chem,Key Lab Pesticide & Chem Bio, Wuhan 430079, Peoples R China.;[Guo, Yanbing; Guo, YB; Luo, Zhu; Wang, Jinlong] Wuhan Inst Photochem & Technol, Wuhan 430082, Peoples R China.;[Wu, Jinsong; Wang, Yutao] Wuhan Univ Technol, Nanostruct Res Ctr, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China.;[Hu, Jinpeng; Wang, Sibo] Fujian Longxin 3D Array Technol Co Ltd, Longyan 364000, Peoples R China.;[Cui, Shuang] SINOPEC Beijing Res Inst Chem Ind Co Ltd, Div Anal, Beijing 100013, Peoples R China.
通讯机构：
[Guo, YB ; Luo, Z] C;Cent China Normal Univ, Inst Environm & Appl Chem, Engn Res Ctr Photoenergy Utilizat Pollut Control &, Minist Educ,Coll Chem,Key Lab Pesticide & Chem Bio, Wuhan 430079, Peoples R China.;Wuhan Inst Photochem & Technol, Wuhan 430082, Peoples R China.
关键词：
(Pt−S−O)-Ti active structure;C3H8 catalytic oxidation;C−H bond activation;Pt-based catalysts;SO2 promotion
摘要：
Typically, SO(2) unavoidably deactivates catalysts in most heterogeneous catalytic oxidations. However, for Pt-based catalysts, SO(2) exhibits an extraordinary boosting effect in propane catalytic oxidation, but the promotive mechanism remains contentious. In this study, an in situ-formed tactful (Pt-S-O)-Ti structure was concluded to be a key factor for Pt/TiO(2) catalysts with a substantial SO(2) tolerance ability. The experiments and theoretical calculations confirm that the high degree of hybridization and orbital coupling between Pt 5d and S 3p orbitals enable more charge transfer from Pt to S species, thus forming the (Pt-S-O)-Ti structure with the oxygen atom dissociated from the chemisorbed O(2) adsorbed on oxygen vacancies. The active oxygen atom in the (Pt-S-O)-Ti active structure is a robust site for C(3)H(8) adsorption, leading to a better C(3)H(8) combustion performance. This work can provide insights into the rational design of chemical bonds for high SO(2) tolerance catalysts, thereby improving economic and environmental benefits.
通讯机构：
[Hu, P ; Yang, Z] H;Hubei Univ Technol, Sch Sci, Wuhan 430068, Peoples R China.
关键词：
aqueous NH4+-ion batteries;one pot synthesis;prussian blue analogues;reversible electrochemical reaction
摘要：
Ammonium‐ion batteries: NH4+‐rich nickel hexacyanoferrate was successfully synthesized through a facile one‐pot method. It exhibits excellent electrochemical performances as cathode material for ammonium‐ion batteries which can be attributed to reversible redox reaction and durable structure. Abstract Rechargeable aqueous batteries based on ammonium‐ion (NH4+) redox reactions shows great potential for large‐scale energy‐storage due to its plentiful supplies, environmental friendliness, intrinsic security, and sustainability. Prussian blue analogues (PBAs) are regarded to be one of the most promising electrode materials owning to high energy storage density, ease of synthesis, and excellent electrochemical performances. However, the synthesis of ammonium rich Prussian blue analogues is too complicated. Herein, a one pot synthesis of NH4+‐rich nickel hexacyanoferrate (NNiHCF) is developed and the NH4+ storage chemistry is investigated. NNiHCF cathode is coupled with an activated carbon (AC) anode and (NH4)2SO4 aqueous electrolyte to assemble ammonium‐ion batteries. The aqueous full cell demonstrates good electrochemical performance, such as 50.2 mAh g−1 at the current rate of 2 C, and 60 % capacity retention in 5000 cycles. Furthermore, the fundamental characteristics of the reversible redox reaction and the durable structure of NNiHCF are revealed by X‐ray diffraction (XRD) and electrochemical measurements. This work proposes a facile method for the synthesis of ammonium‐rich Prussian.
摘要：
In coding theory, it is important to construct codes with optimal parameters. The codes meeting the Griesmer bound are called Griesmer codes. In this paper, we prove nonexistence of some Griesmer codes of dimension four over finite fields of cardinality eight and nine using projective geometry. Moreover, we improve 24 cases on code lengths for given minimal distance and dimension four. Two precise lower bounds of code lengths have also been determined.
期刊：
ELECTRONIC JOURNAL OF COMBINATORICS,2024年31(1) ISSN：1077-8926
通讯作者：
Li, SC
作者机构：
[Lei, Xingyu; Li, Shuchao; Li, SC] Cent China Normal Univ, Fac Math & Stat, Wuhan 430079, Peoples R China.
通讯机构：
[Li, SC ] C;Cent China Normal Univ, Fac Math & Stat, Wuhan 430079, Peoples R China.
摘要：
For a given graph F, we say that a graph G is F -free if it does not contain F as a subgraph. A graph is color -critical if it contains an edge whose deletion reduces its chromatic number. Let Kr+ (a1, a2,... , ar) be the graph obtained from complete r -partite graph with parts of sizes a1 2, a2, ... , ar, by adding an edge to the first part. In this paper, we focus on the spectral extrema of disjoint colorcritical graphs. For fixed t, a1, ... , ar (r 2) and large enough n, we characterize the unique n -vertex tKr+ (a1, ... , ar)-free graph having the largest spectral radius. Moreover, let F1, ... , Ft be t disjoint color -critical graphs with the same chromatic number. We identify the unique n -vertex Uti=1 Fi-free graph having the largest spectral radius for sufficiently large n. Consequently, we generalize the main results obtained by Ni, Wang and Kang
关键词：
Biochar leachate;Nitrate assimilation;Nitrogen fixation;Nitrogen-fixing cyanobacteria;Photosynthetic system
摘要：
Biochar contains biotoxic aromatic compounds, and their influence on nitrogen-fixing cyanobacteria, the critical nitrogen fixer in paddy soil, has never been tested. Here, the physiological, metabolomic, and transcriptomic analyses of Nostoc sp. PCC7120 in response to biochar leachate were performed. The results suggested that biochar leachate inhibited the efficiency of photosynthesis, nitrogen fixation, and nitrate assimilation activities of nitrogen-fixing cyanobacteria. Biochar leachate containing aromatic compounds and odd- and long-chain saturated fatty acids impaired the membrane structure and antenna pigments, damaged the D1 protein of the oxygen evolution complex, and eventually decreased the electron transfer chain activity of photosystem II. Moreover, the nitrogen fixation and nitrate assimilation abilities of nitrogen-fixing cyanobacteria were inhibited by a decrease in photosynthetic productivity. A decrease in iron absorption was another factor limiting nitrogen fixation efficiency. Our study highlights that biochar with relatively high contents of dissolved organic matter poses a risk to primary nitrogen assimilation reduction and ecosystem nitrogen loss. Further evidence of the potential negative effects of biochar leachates on the fixation and assimilation capacity of nitrogen by soil microbes is needed to evaluate the impact of biochar on soil multifunctionality prior to large-scale application.
作者机构：
[Liu, Lijuan; Zhang, Lizhi; Gong, JM; Meng, Mingxia; Gong, Jingming; Yao, Qingfeng; Cai, Zheng; Sun, Hongwei; Jiang, Fang] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticide & Chem Biol, Coll Chem,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Gong, JM ] C;Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticide & Chem Biol, Coll Chem,Minist Educ, Wuhan 430079, Peoples R China.
摘要：
As emerging contaminants in the environment, antibiotic resistance genes (ARGs) have aroused a global health crisis and posed a serious threat to ecological safety and human health. Thus, efficient and accurate onsite detection of ARGs is crucial for environmental surveillance. Here, we presented a colorimetric-photoelectrochemical (PEC) dual-mode bioassay for simultaneous detection of multiple ARGs by smartly incorporating rolling circle amplification (RCA) into a stimuli-responsive DNA nanoassembly, using the tetracycline resistance genes tetA and tetC as models. The tailored DNA nanoassembly containing RCA amplicons hybridized with specific signal probes: CuO nanoflowers-anchored signal DNA1 and HgO nanoparticles-anchored signal DNA2, respectively. Upon exposure to an acidic stimulus, numerous Cu(2+) and Hg(2+) were released, serving as the reporting agent of colorimetric/PEC dual-mode assay. The released Cu(2+) and Hg(2+) induced localized surface plasmon resonance shifts in Au nanorods and triangular Ag nanoplates through an etching process, respectively, enabling visual analysis of ARGs with distinguishing color changes. Meanwhile, numerous Cu(2+) and Hg(2+) triggered the amplified PEC variations via reacting with the photoactive layers of CuS/CdS and ZnS, respectively. Thus, a rapid and ultrasensitive colorimetric/PEC dual-mode detection of multiple ARGs was achieved with the detection limit down to 17.2 aM. Furthermore, such dual-mode bioassay could discriminate single-base mismatch and successfully determine ARGs in E. coli plasmids and sludge samples, holding great promise for point-of-care genetic diagnostics.
摘要：
Maritime transportation plays a crucial role in global trade and economic development. However, this industry is exposed to various risks (e.g., natural disasters), which can cause significant economic and environmental damage. This study aims to develop a spatial risk assessment approach for maritime transportation using machine learning and geospatial big data to identify potential risks in China's maritime transportation industry. The proposed approach first produces risk maps that reveal significant variability in maritime transportation risks across different regions of China. Then, factor importance analysis identifies wave height, rainfall, and sea surface temperature as the most influential factors affecting navigational safety. Finally, capability indicators are employed to analyze the matching relationship between coastal search and rescue resources and maritime transportation risks. Our study provides valuable references for enhancing maritime emergency response capabilities and protecting marine ecological environments.
期刊：
FRONTIERS IN ECOLOGY AND EVOLUTION,2024年11:1332116 ISSN：2296-701X
通讯作者：
Wu, W
作者机构：
[Wu, Shuai] Cent China Normal Univ, Inst China Rural Studies, Wuhan, Peoples R China.;[Wu, Shuai] Cent China Normal Univ, Sch Publ Adm, Wuhan, Peoples R China.;[Wu, W; Wu, Wei] Guizhou Univ, Min Coll, Guiyang, Guizhou, Peoples R China.
通讯机构：
[Wu, W ] G;Guizhou Univ, Min Coll, Guiyang, Guizhou, Peoples R China.
关键词：
Autumn phenology;the start of brown-down phase (SOB);the end of brown-down phase (EOB);the length of brown-down phase (LOB);Temporal Trends;temperate China
摘要：
Land surface phenology plays a crucial role in accurately parameterizing interactions between land ecosystems and the atmosphere. Changes in autumn phenology directly impact the length of vegetation growing season and year-to-year changes in carbon uptake. Previous studies have often focused solely on the end of growing season when characterizing autumn phenology, neglecting the onset and duration of autumn. Here, we extracted the annual autumn phenological metrics, i.e., the start of brown-down phase (SOB), the end of brown-down phase (EOB), and the length of brown-down phase (LOB), for temperate China from 1982 to 2018 based on our self-developed global LSP dataset. We conducted a comparative analysis of SOB, EOB, and LOB in the field of their spatial distribution, temporal trends, and performance on various categories of vegetated regions (i.e., forests, grasslands, croplands, and vegetated areas in urban lands (V_Urban)). The results showed a significant negative correlation between the timing of autumn phenological metrics and latitude in temperate China. Between 1982 and 2018, there were significant positive increasing trends in EOB and LOB in V_Urban, as well as in LOB in forests in temperate China. However, the annual mean SOB, EOB, and LOB did not show significant trends across the entire study area. At the local pixel scale, SOB, EOB, and LOB exhibited a combination of advanced and delayed trends within various vegetated categories. The trends of the same phenological metric were not uniform across these diverse vegetated regions. For instance, the majority of pixels with significant trends in SOB exhibited delayed trends in forests and croplands, while displaying advanced trends in grasslands and V_Urban. In this study, employing three metrics (SOB, EOB, and LOB) to describe autumn phenology enhances our understanding of the impacts of global climate change on ecosystems, offering a more comprehensive and detailed perspective. In the future, satellite-based monitoring and phenological modeling should contemplate incorporating additional potential phenological metrics.
作者机构：
[Zhang, Miao] Cent China Normal Univ, Natl Engn Res Ctr E Learning, Wuhan 430079, Peoples R China.;[Zhang, Miao; He, Tingting; Dong, Ming; Dong, M] Cent China Normal Univ, Hubei Prov Key Lab Artificial Intelligence & Smart, Wuhan 430079, Peoples R China.;[Zhang, Miao; He, Tingting; Dong, Ming; Dong, M] Cent China Normal Univ, Natl Language Resources Monitoring & Res Ctr Netwo, Wuhan 430079, Peoples R China.;[He, Tingting; Dong, Ming; Dong, M] Cent China Normal Univ, Sch Comp, Wuhan 430079, Peoples R China.
通讯机构：
[He, TT; Dong, M ] C;Cent China Normal Univ, Hubei Prov Key Lab Artificial Intelligence & Smart, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Natl Language Resources Monitoring & Res Ctr Netwo, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Sch Comp, Wuhan 430079, Peoples R China.
摘要：
Commonsense question answering (CQA) requires understanding and reasoning over QA context and related commonsense knowledge, such as a structured Knowledge Graph (KG). Existing studies combine language models and graph neural networks to model inference. However, traditional knowledge graph are mostly concept-based, ignoring direct path evidence necessary for accurate reasoning. In this paper, we propose MRGNN (Meta-path Reasoning Graph Neural Network), a novel model that comprehensively captures sequential semantic information from concepts and paths. In MRGNN, meta-paths are introduced as direct inference evidence and an original graph neural network is adopted to aggregate features from both concepts and paths simultaneously. We conduct sufficient experiments on the CommonsenceQA and OpenBookQA datasets, showing the effectiveness of MRGNN. Also, we conduct further ablation experiments and explain the reasoning behavior through the case study.
期刊：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2024年311:123979 ISSN：1386-1425
通讯作者：
Liu, SH;Zhang, J
作者机构：
[Peng, Zhen; Liu, Sheng Hua; Liu, SH] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Zhang, Jing; Feng, Na; Zhang, J] Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou 510515, Peoples R China.;[Zhang, Jianyu] Hong Kong Univ Sci & Technol, Hong Kong Branch, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Dept Chem,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China.;[Zhang, Jianyu] Hong Kong Univ Sci & Technol, Inst Adv Study, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China.
通讯机构：
[Liu, SH ] C;[Zhang, J ] S;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou 510515, Peoples R China.
摘要：
High-performance luminescent gold(I) complexes have attracted considerable attention due to their potential applications in various fields, but their construction is a significantly challenging task. Herein, we designed and synthesized a series of novel dinuclear gold(I) complexes 1-4 based on 1,2-bis(diphenylphosphino)benzene and 1,4-bis(diphenylphosphino)benzene frameworks, where para-substitutions of benzene ring were employed for comparison and bulky t-butyl groups were introduced into carbazole ligands to assist flexibly regulating the aurophilicity. Among them, the structure of complex 1 was confirmed by single-crystal X-ray diffraction, and all the complexes exhibited typical aggregation-induced emission characteristics. Due to the construction of intramolecular aurophilicity and the formation of molecular clusters, noticeable enhancement of the luminescent efficiency was achieved for the core complex 1. Together with the introduction of flexible t-butyl groups, good responsiveness towards external mechanical force and solvent vapors were also realized. Moreover, the specific bioimaging ability of complex 1 towards cancer cells was demonstrated. Thus, this work presents the crucial capability of aurophilic manipulation in tuning the luminescence and smart behaviors of gold complexes, and it will open a new route to developing high-performance luminescent materials.
摘要：
In this paper, we construct a bounce inflation cosmological scenario in the framework of the modified symmetric teleparallel gravity, namely f(Q) theory, and investigate the tensor perturbations therein. As is well-known, the tensor perturbations generated in the very early Universe (inflation and pre-inflation regions) can account for the primordial gravitational waves (PGWs) that are to be detected by the next generation of GW experiments. We discuss the stability condition of the tensor perturbations in the bounce inflation process and investigate in detail the evolution of the perturbation variable. The general form of the tensor power spectrum is obtained both for large as well as small scale modes. As a result, we show both kinds of modes (short or long wavelength modes), and the tensor spectrum may get a positive tilt in the parametric range where the tensor perturbation proves to be stable-this interestingly hints an enhancement of gravitational waves' amplitude in the background of the f(Q) bounce-inflation scenario. Moreover, we study the LQC-like scenario as a specific case of our model, in which, the primordial tensor power spectrum turns out to be nearly scale-invariant on both small and large scales.
