通讯机构：
[Tan, HT ; Xiong, H ] H;[Li, J ] Z;[Ding, MS ] D;Dalian Polytech Univ, Basic Educ Dept, Dalian 116034, Peoples R China.;Huazhong Normal Univ, Dept Phys, Wuhan 430079, Peoples R China.
关键词：
cavity quantum electrodynamics;hybrid magnonics;magnomechanics;optomechanics;quantum optics;quantum information
摘要：
Hybrid quantum systems based on magnons in magnetic materials have made significant progress in the past decade. They are built based on the couplings of magnons with microwave photons, optical photons, vibration phonons, and superconducting qubits. In particular, the interactions among magnons, microwave cavity photons, and vibration phonons form the system of cavity magnomechanics (CMM), which lies in the interdisciplinary field of cavity QED, magnonics, quantum optics, and quantum information. Here, we review the experimental and theoretical progress of this emerging field. We first introduce the underlying theories of the magnomechanical coupling, and then some representative classical phenomena that have been experimentally observed, including magnomechanically induced transparency, magnomechanical dynamical backaction, magnon-phonon cross-Kerr nonlinearity, etc. We also discuss a number of theoretical proposals, which show the potential of the CMM system for preparing different kinds of quantum states of magnons, phonons, and photons, and hybrid systems combining magnomechanics and optomechanics and relevant quantum protocols based on them. Finally, we summarize this review and provide an outlook for the future research directions in this field.
摘要：
The United Nations has proposed Sustainable Development Goals (SDGs), of which SDG11 aims to "make cities and human settlements inclusive, safe, resilient and sustainable". This is in line with Urban Vitality's objectives. This study proposes a quantitative framework to evaluate the impact of urban morphology on urban vitality. In this framework, a proxy that is more reflective of economic and human activities is proposed for depicting urban vitality based on geographic big data; then we use a Multi-scale Geographically Weighted Regression (MGWR) regression considering spatial heterogeneity to analyze the different effects of urban form on urban vitality. Taking the Beijing Sixth Ring Road area as the study region, the results indicate that tall, large-area, multi-functional buildings have a significantly positive impact on urban vitality. These areas exhibit single-function buildings and high levels of greenery, leading to inefficient space utilization. Increasing road network density, as well as the density of transportation and public facilities, also positively influences urban vitality. However, commercial density has a negative impact on workday vitality. Furthermore, excessive green space density, a high proportion of the largest green patches, and complex green space borders all contribute to a reduction in urban vitality.
摘要：
Revegetation is effective in improving soil quality in ecologically fragile areas. However, little is known about the impact of diverse phytomanagement strategies of tailings on soil quality and ecological security in erosion-prone areas. We investigated the water stability, soil aggregate nutrients, and the risk of heavy metal contamination of abandoned tailings under phytomanagement and in adjacent bare land on the Loess Plateau. The results showed that phytomanagement significantly enhanced soil aggregate stability, as demonstrated by higher contents of soil organic carbon (SOC), glomalin-related soil protein (GRSP), aromatic-C, and alkene-C in macro-aggregates. The pollution load index (PLI) and ecological risk index (RI) of soil heavy metals were lower in shrub/herbaceous mixed forests than in natural grasslands and planted forests. The risk of heavy metal contamination was higher in macro-aggregates (>0.25 mm) than in micro-aggregates (<0.25 mm) and was significantly and positively correlated with the SOC and GRSP contents of the aggregates. Our study demonstrates that soil aggregate quality is closely related to the fate of heavy metals. Diversified tailing revegetation measures can improve soil quality and ensure ecological security.
期刊：
Journal of Mathematical Analysis and Applications,2024年537(1):128270 ISSN：0022-247X
通讯作者：
Huang, JC
作者机构：
[Chen, Shuang; Huang, Jicai] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China.;[Chen, Shuang; Huang, Jicai] Cent China Normal Univ, Hubei Key Lab Math Sci, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Huang, JC ] C;Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Math Sci, Wuhan 430079, Hubei, Peoples R China.
摘要：
In this paper, we study the destabilization of synchronous periodic solutions for patch models. By applying perturbation theory for matrices, we derive asymptotic expressions of the Floquet spectra and provide a destabilization criterion for synchronous periodic solutions arising from closed orbits or degenerate Hopf bifurcations in terms of period functions. Finally, we apply the main results to the well-known two -patch Holling-Tanner model. (c) 2024 Elsevier Inc. All rights reserved.
期刊：
Journal of Mathematical Biology,2024年88(4):1-30 ISSN：0303-6812
通讯作者：
Lu, M
作者机构：
[Lu, Min; Huang, Jicai; Pan, Qin] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China.;[Lu, Min; Huang, Jicai; Pan, Qin] Cent China Normal Univ, Key Lab NAA, MOE, Wuhan 430079, Peoples R China.;[Ruan, Shigui] Univ Miami, Dept Math, Coral Gables, FL 33146 USA.
通讯机构：
[Lu, M ] C;Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Key Lab NAA, MOE, Wuhan 430079, Peoples R China.
关键词：
Bogdanov–Takens bifurcation;Harvesting;Holling I functional response;Hopf bifurcation;Krill–whale interaction;Predator–prey model
摘要：
In the Antarctic, the whale population had been reduced dramatically due to the unregulated whaling. It was expected that Antarctic krill, the main prey of whales, would grow significantly as a consequence and exploratory krill fishing was practiced in some areas. However, it was found that there has been a substantial decline in abundance of krill since the end of whaling, which is the phenomenon of krill paradox. In this paper, to study the krill–whale interaction we revisit a harvested predator–prey model with Holling I functional response. We find that the model admits at most two positive equilibria. When the two positive equilibria are located in the region
$$\big \{(N,P)|0\le N< 2N_c,\ P\ge 0\big \}$$
, the model exhibits degenerate Bogdanov–Takens bifurcation with codimension up to 3 and Hopf bifurcation with codimension up to 2 by rigorous bifurcation analysis. When the two positive equilibria are located in the region
$$\big \{(N,P)|N>2N_c,\ P\ge 0\big \}$$
, the model has no complex bifurcation phenomenon. When there is one positive equilibrium on each side of
$$N=2N_c$$
, the model undergoes Hopf bifurcation with codimension up to 2. Moreover, numerical simulation reveals that the model not only can exhibit the krill paradox phenomenon but also has three limit cycles, with the outmost one crosses the line
$$N=2N_c$$
under some specific parameter conditions.
摘要：
Regioselective 1,2-dichalcogenation of alkenes has attracted significant attention in modern organic synthetic chemistry. While there are a plethora of methods to access alkene dichalcogenated architectures, sulfonylsulfination of alkenes is extremely challenging due to the inherent characteristics of the sulfur atom. Herein, a multicomponent fragment coupling of alkenes, sulfinates, and DABSO was developed to construct densely functionalized sulfonylsulfinated products, which are otherwise challenging to access, with broad substrate scope and group tolerance under mild and operationally simple conditions, using an inexpensive 100-1000 ppm organic photocatalyst. In addition, the protocol was applied to the late-stage functionalization of complex molecules, and the obtained products were converted into diverse downstream transformations to demonstrate their synthetic potential. Experimental and theoretical mechanistic investigations suggest that these reactions proceed through sequential sulfonyl and sulfinyl oxygen radical mutual transformations and radical-polar crossover coupling. This strategy provides access to previously inaccessible alkene sulfonylsulfinated products in good-to-high regio- and stereoselectivity, along with opening up previously unexplored synthetic directions.
作者机构：
[Xu, Yuling; Luo, Lishi; Sun, Yao; Pang, Yida; Yang, Jingfang; Li, Chonglu] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Luo, Lishi] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.;[Sharma, Amit] Amity Univ Punjab, Amity Sch Chem Sci, Dept Phys, Mohali 140306, India.;[Liu, Shuang] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, Peoples R China.;[Zhan, Jianbo] Hubei Prov Ctr Dis Control & Prevent, Inst Hlth Inspect & Testing, Wuhan, Hubei, Peoples R China.
通讯机构：
[Sun, Y ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Albeit sonodynamic therapy (SDT) has achieved encouraging progress in microbial sterilization, the scarcity of guidelines for designing highly effective sonosensitizers and the intricate biofilm microenvironment (BME), substantially hamper the therapeutic efficacy against biofilm infections. To address the bottlenecks, we innovatively design a Ru(II) metallacycle-based sonosensitizer/sonocatalyst (named Ru-A3-TTD) to enhance the potency of sonotherapy by employing molecular engineering strategies tailored to BME. Our approach involves augmenting Ru-A3-TTD’s production of ultrasonic-triggered reactive oxygen species (ROS), surpassing the performance of commercial sonosensitizers, through a straightforward but potent π-expansion approach. Within the BME, Ru-A3-TTD synergistically amplifies sonotherapeutic efficacy via triple-modulated approaches: (i) effective alleviation of hypoxia, leading to increased ROS generation, (ii) disruption of the antioxidant defense system, which shields ROS from glutathione consumption, and (iii) enhanced biofilm penetration, enabling ROS production in deep sites. Notably, Ru-A3-TTD sono-catalytically oxidizes NADPH, a critical coenzyme involved in antioxidant defenses. Consequently, Ru-A3-TTD demonstrates superior biofilm eradication potency against multidrug-resistant Escherichia coli compared to conventional clinical antibiotics, both in vitro and in vivo. To our knowledge, this study represents the pioneering instance of a supramolecular sonosensitizer/sonocatalyst. It provides valuable insights into the structure-activity relationship of sonosensitizers and paves a promising pathway for the treatment of biofilm infections.
期刊：
Landscape and Urban Planning,2024年241:104924 ISSN：0169-2046
通讯作者：
Xiao, CW
作者机构：
[Wang, Yi; Xiao, Chiwei; Xiao, CW; Yan, Mingyan; Chiaka, Jeffrey Chiwuikem] Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, 11A Datun Rd, Beijing, Peoples R China.;[Wang, Yi; Xiao, Chiwei; Xiao, CW] Univ Chinese Acad Sci, Coll Resources & Environm, 1 Yanqihu East Rd, Beijing, Peoples R China.;[Wang, Yi; Yan, Mingyan] Cent China Normal Univ, Coll Publ Adm, 382 Luoyu Rd, Wuhan, Peoples R China.;[Chiaka, Jeffrey Chiwuikem] Beijing Normal Univ, Sch Environm, 19 Xinjiekou, Beijing, Peoples R China.
通讯机构：
[Xiao, CW ] C;Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, 11A Datun Rd, Beijing, Peoples R China.;Univ Chinese Acad Sci, Coll Resources & Environm, 1 Yanqihu East Rd, Beijing, Peoples R China.
关键词：
Land -use change;Landscape pattern;Geo-economic cooperation;Cross-border transportation corridors;China -Laos Railway
摘要：
Regional integration initiatives have triggered impacts on land use changes (LUC) and landscape patterns through geo-economic cooperation like cross-border infrastructure, which are often presented, but comprehensive studies on the extent and degree remains insufficient. The China-Laos Railway (CLR), a cross-border transportation corridor connecting Kunming in China with the Laotian capital, Vientiane, which was launched in December 2016 and operation started in December 2021, has recently witnessed rapid and notable changes in landscape and land use. This case study provides a distinctive opportunity to evaluate the relative significance of political and socioeconomic factors on LUC and landscape patterns. In this study, we integrate 10-m land-use data products (2017–2022) provided by Environmental Systems Research Institute, Inc (ESRI) with geospatial analysis to quantify and compare the impacts of cross-border transportation corridors on LUC within a 10 km buffer area along the CLR. The results showed that since 2017, about 3 % deforestation caused by the expansion of cropland (8 %) and construction land (38 %) along the CLR. The comprehensive dynamic degree along the CLR displays two peaks, appearing within the 2–4 km and 8–10 km buffer zones. Interestingly, the fragmentation of land patches within the buffer zone decreases as the distance from the CLR increases. Moreover, the construction of the CLR has a greater impact on the Laotian side, while its completion and operation triggered more significant changes on the Chinese side. The study quantitatively assesses the extent, type, and intensity of the impacts of cross-border transportation corridors on LUC and landscape patterns.
作者：
Banerjee, Malay;Huang, Jicai;Pan, Qin;Zou, Lan
期刊：
DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B,2024年 ISSN：1531-3492
通讯作者：
Zou, L
作者机构：
[Banerjee, Malay] IIT Kanpur, Dept Math & Stat, Kanpur 208016, India.;[Huang, Jicai; Pan, Qin] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China.;[Zou, Lan; Zou, L] Capital Normal Univ, Sch Math Sci, Beijing 100089, Peoples R China.
通讯机构：
[Zou, L ] C;Capital Normal Univ, Sch Math Sci, Beijing 100089, Peoples R China.
关键词：
Key words and phrases. Generalist predator;stability;limit cycle;Hopf bifurcation;Bogdanov- Takens bifurcation
摘要：
. Consideration of generalist predators leads to relatively complex dynamics due to alternative food sources. Here, we propose and analyze a prey-predator model with a generalist predator. The availability of alternative food sources for the predator and a density-dependent growth rate induces not only bistability and tristability, but also more complicated dynamical behaviors. We have studied the possible number and geometric configurations of positive equilibria in detail. A systematic bifurcation analysis has revealed the existence of the degenerate Bogdanov-Takens bifurcation of codimension four and degenerate Hopf bifurcation of codimension three. We found that degenerate local bifurcations with a higher codimension are responsible for three limit cycles. Derivation of the analytical conditions for three limit cycles for a suitable range of parameters is a crucial finding of this work.
关键词：
Semantic processing;Word sense disambiguation;Anaphora resolution;Named entity recognition;Concept extraction;Subjectivity detection
摘要：
Semantic processing is a fundamental research domain in computational linguistics. In the era of powerful pre-trained language models and large language models, the advancement of research in this domain appears to be decelerating. However, the study of semantics is multi-dimensional in linguistics. The research depth and breadth of computational semantic processing can be largely improved with new technologies. In this survey, we analyzed five semantic processing tasks, e.g., word sense disambiguation, anaphora resolution, named entity recognition, concept extraction, and subjectivity detection. We study relevant theoretical research in these fields, advanced methods, and downstream applications. We connect the surveyed tasks with downstream applications because this may inspire future scholars to fuse these low-level semantic processing tasks with high-level natural language processing tasks. The review of theoretical research may also inspire new tasks and technologies in the semantic processing domain. Finally, we compare the different semantic processing techniques and summarize their technical trends, application trends, and future directions.
关键词：
Photocatalysis;H2O2;g-C3N4;Excitons dissociation;Reactive oxygen species
摘要：
Solar-driven hydrogen peroxide (H2O2) production offers a sustainable strategy to address the ever-growing demand of eco-friendly oxidant and clean fuel, while its efficiency highly relies on the generation of desired reactive oxygen species (ROSs). Herein, we demonstrate that introducing boron-nitrogen vacancy (B-N-V) associates in g-C3N4 enables to weaken the robust excitonic effect and promote bound excitons spontaneously dissociating into free charge carriers under ambient conditions. Specifically, the doped B atoms introduced a donor state below the conduction band of g-C3N4, which disturbs charge distribution around heptazine rings and further destabilizes excitons. The concomitant N-V, serving as an accepter state locating above the valence band, cooperates with the doped B atoms to form B-N-V associates that simultaneously downshifts the conduction band and valence band of g-C3N4. Distinct from the counterpart preferring to activate O-2 into O-1(2) via an energy-transfer-involved pathway, g-C3N4 featuring with B-N-V associates displayed a superior photoactivity of visible-light-driven two-electron oxygen reduction reaction for H2O2 production with a yield of 182 mu mol h(-1) and selectivity of 100%. The produced H2O2 could effectively degrade organic contaminants and kill typical bacteria. This study highlights the importance of ROSs generation in two-dimensional photocatalysts for sustainable solar-to-chemical conversion and on site environmential governance.
作者机构：
[Wang, Ying; Ge, Kun] Jiangxi Normal Univ, Coll City Construct, Dept Engn Management & Real Estate, Nanchang, Peoples R China.;[Liu, Xiaoyuan] Jiangxi Normal Univ, Coll Fine Arts, Dept Environm Design, Nanchang, Peoples R China.;[Lu, Xinhai] Huazhong Univ Sci & Technol, Coll Publ Adm, Dept Land Management, Wuhan, Peoples R China.;[Ke, Shangan] Cent China Normal Univ, Sch Publ Adm, Dept Land Resources Management, Wuhan, Peoples R China.;[Liu, Xiaoyuan; Liu, XY] Jiangxi Normal Univ, Coll Fine Arts, Dept Environm Design, Nanchang 330022, Jiangxi, Peoples R China.
通讯机构：
[Liu, XY ] J;[Ke, SA ] C;Jiangxi Normal Univ, Coll Fine Arts, Dept Environm Design, Nanchang 330022, Jiangxi, Peoples R China.;Cent China Normal Univ, Sch Publ Adm, Dept Land Resources Management, Wuhan 430079, Hubei, Peoples R China.
关键词：
Green transition of urban land use;Industrial integration;Spatio-temporal differences;Convergence mechanisms
摘要：
Revealing the spatial differences and the convergence mechanisms of Green Transition of Urban Land Use (GTULU) in the context of industrial integration is of great significance for formulating differentiated industrial development strategies, accelerating the process of industrial integration, and exploring synergistic enhancement paths of GTULU. In this paper, 107 prefecture-level and above cities in the Yangtze River Economic Belt (YREB) are taken as research objects, and the entropy value method, exploratory spatial data analysis model and spatial convergence model are comprehensively applied to analyze the spatio-temporal differences and spatial convergence of the GTULU under the background of industrial integration. The study shows that: (1) from 2003 to 2021, the level of GTULU in the YREB has been increasing, with the mean value growing from 0.09 to 0.14, but there are still significant spatial differentiation and spatial correlation characteristics, and the regional imbalance phenomenon of GTULU is more and more obvious as time goes by. (2) The GTULU of the YREB and its upstream, midstream, and downstream regions all exhibit a temporal evolution characteristic of increasing fluctuations. (3) There is no sigma-convergence in GTULU in the YREB and its upstream, middle-stream, and downstream regions. However, there are all significant absolute beta convergence and conditional beta convergence. Moreover, under the combined influence of government management, technological input, industrial structural adjustment, and spatial impact, the convergence rate of the YREB has significantly accelerated, from 1.98% to 2.31%, and the convergence effect exhibits marked heterogeneity.
摘要：
Cadmium (Cd) is a harmful environmental pollutant that disrupts public health, including respiratory, digestive, and reproductive systems. In this study, male rats were exposed to CdCl(2) at a dose of 3mg/kg by oral for 28 days to investigate the impact on spermatogenesis. Testis tissue samples were collected after sacrifice, and piRNA expression levels were measured using piRNA microarray and qPCR. PiRNAs, specialized molecules involved in spermatogenesis, were examined. CdCl(2) exposure led to disrupted piRNA expression, particularly in piRNA-DQ759395 in rats. This piRNA was found to have a binding site with p53, and a similar piRNA-DQ717867 was discovered in mice. In GC-2spd cells, CdCl(2) exposure increased piRNA-DQ717867 expression, which resulted in cell cycle arrest and abnormal expression of cell cycle-related proteins. The activation of p53-related pathways and disruptions in cell cycle regulation were also observed. Antagomir-717867 transfections and PFT-a pretreatment in GC-2spd cells supported the involvement of piRNA-DQ717867 in regulating cell cycle-related proteins. This study suggests that Cd exposure induces abnormal expression of piRNA-DQ759395 in rat testis and that piRNA-DQ717867 may regulate p53, causing cell cycle abnormalities in GC-2spd cells. These findings help understand the mechanisms of male reproductive toxicity caused by Cd exposure and emphasize the role of piRNAs in cell cycle regulation and male reproductive health.
期刊：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2024年72(13):7021-7032 ISSN：0021-8561
通讯作者：
Feng, LL
作者机构：
[Zuo, Lingzi; Fan, Yuxuan; Feng, LL; Feng, Lingling; He, Yanlin; Cheng, Cai; Zhang, Liexiong; Guo, Xiaoliang; Cheng, Guonian; Yu, Jie; Tang, Guangmei; Huang, Shi; Chen, Ruiqing] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Liu, Yanyang; Feng, LL; Feng, Lingling] Wuhan Inst Photochem & Technol, Wuhan 430083, Hubei, Peoples R China.;[Feng, LL; Feng, Lingling] Cent China Normal Univ, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Feng, LL ] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;Wuhan Inst Photochem & Technol, Wuhan 430083, Hubei, Peoples R China.;Cent China Normal Univ, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
关键词：
Active substructure splicing;DFT;Harmful cyanobacteria blooms;SAR;algicide;thioacetamide derivatives
摘要：
Lakes and reservoirs worldwide are experiencing a growing problem with harmful cyanobacterial blooms (HCBs), which have significant implications for ecosystem health and water quality. Algaecide is an effective way to control HCBs effectively. In this study, we applied an active substructure splicing strategy for rapid discovery of algicides. Through this strategy, we first optimized the structure of the lead compound S5, designed and synthesized three series of thioacetamide derivatives (series A, B, C), and then evaluated their algicidal activities. Finally, compound A3 with excellent performance was found, which accelerated the process of discovering and developing new algicides. The biological activity assay data showed that A3 had a significant inhibitory effect on M. aeruginosa. FACHB905 (EC(50) = 0.46 μM) and Synechocystis sp. PCC6803 (EC(50) = 0.95 μM), which was better than the commercial algicide prometryn (M. aeruginosa. FACHB905, EC(50) = 6.52 μM; Synechocystis sp. PCC6803, EC(50) = 4.64 μM) as well as better than lead compound S5 (M. aeruginosa. FACHB905, EC(50) = 8.80 μM; Synechocystis sp. PCC6803, EC(50) = 7.70 μM). The relationship between the surface electrostatic potential, chemical reactivity, and global electrophilicity of the compounds and their activities was discussed by density functional theory (DFT). Physiological and biochemical studies have shown that A3 might affect the photosynthesis pathway and antioxidant system in cyanobacteria, resulting in the morphological changes of cyanobacterial cells. Our work demonstrated that A3 might be a promising candidate for the development of novel algicides and provided a new active skeleton for the development of subsequent chemical algicides.
期刊：
BRIEFINGS IN BIOINFORMATICS,2024年25(2) ISSN：1467-5463
通讯作者：
Peng, YH
作者机构：
[Xu, Wang; Peng, Yunhui; Zhang, Houfang; Peng, YH; Zhao, Yunjie] Cent China Normal Univ, Inst Biophys, Wuhan, Peoples R China.;[Xu, Wang; Peng, Yunhui; Zhang, Houfang; Peng, YH; Zhao, Yunjie] Cent China Normal Univ, Dept Phys, Wuhan, Peoples R China.;[Guo, Wenhan] Univ Texas El Paso, Computat Sci Program, El Paso, TX USA.;[Jiang, Lijun] Cent China Normal Univ, Sch Life Sci, Wuhan, Peoples R China.
通讯机构：
[Peng, YH ] C;Cent China Normal Univ, Inst Biophys, Wuhan, Peoples R China.;Cent China Normal Univ, Dept Phys, Wuhan, Peoples R China.
关键词：
histone/nucleosome interaction;interaction network;histone cancer mutation;nucleosome binding mode;epigenetic regulation
摘要：
Nucleosomes represent hubs in chromatin organization and gene regulation and interact with a plethora of chromatin factors through different modes. In addition, alterations in histone proteins such as cancer mutations and post-translational modifications have profound effects on histone/nucleosome interactions. To elucidate the principles of histone interactions and the effects of those alterations, we developed histone interactomes for comprehensive mapping of histone-histone interactions (HHIs), histone-DNA interactions (HDIs), histone-partner interactions (HPIs) and DNA-partner interactions (DPIs) of 37 organisms, which contains a total of 3808 HPIs from 2544 binding proteins and 339 HHIs, 100 HDIs and 142 DPIs across 110 histone variants. With the developed networks, we explored histone interactions at different levels of granularities (protein-, domain- and residue-level) and performed systematic analysis on histone interactions at a large scale. Our analyses have characterized the preferred binding hotspots on both nucleosomal/linker DNA and histone octamer and unraveled diverse binding modes between nucleosome and different classes of binding partners. Last, to understand the impact of histone cancer-associated mutations on histone/nucleosome interactions, we complied one comprehensive cancer mutation dataset including 7940 cancer-associated histone mutations and further mapped those mutations onto 419,125 histone interactions at the residue level. Our quantitative analyses point to histone cancer-associated mutations' strongly disruptive effects on HHIs, HDIs and HPIs. We have further predicted 57 recurrent histone cancer mutations that have large effects on histone/nucleosome interactions and may have driver status in oncogenesis.
期刊：
Swarm and Evolutionary Computation,2024年85:101460 ISSN：2210-6502
通讯作者：
Chen, YN
作者机构：
[Wei, Luona] South Cent Minzu Univ, Coll Elect & Informat Engn, Wuhan 430074, Peoples R China.;[Chen, YN; Chen, Ming; Chen, Yuning; Chen, Yingwu] Natl Univ Def Technol, Coll Syst Engn, Changsha 410073, Peoples R China.;[Xing, Lining] Xidian Univ, Coll Elect Engn, Xian 710126, Peoples R China.;[Wand, Qian] Cent China Normal Univ, Natl Engn Res Ctr Educ Big Data, Wuhan 430079, Peoples R China.;[Song, Yanjie] Natl Def Univ, Beijing 100091, Peoples R China.
通讯机构：
[Chen, YN ] N;Natl Univ Def Technol, Coll Syst Engn, Changsha 410073, Peoples R China.
关键词：
Agile satellite scheduling;Multi-objective;Genetic programming;Knowledge transfer
摘要：
The multi -objective dynamic agile earth observation satellite scheduling problem (MO-DAEOSSP) aims to schedule a set of real-time arrival requests and form a reasonable observation plan to satisfy various criteria. According to the requirements in practical applications, the total profit and the average image quality of scheduled requests are taken as optimization goals in this study. Compared to manually designed heuristics and iterative -based methods used in previous research, genetic programming based hyper heuristics (GPHH) can automatically evolve high -quality heuristic rules (HRs) for real-time scheduling without being highly dependent on expert knowledge. In this paper, a knowledge -transfer based multi -objective GPHH framework (KT-MOGP) is proposed, equipped with a heuristic -based simulation considering the idle monitoring, to evolve non -dominated HRs for solving MO-DAEOSSP. The heuristic -based simulation generates feasible schedules and returns fitness values for given HRs, which are the individuals evolved by KT-MOGP. KT-MOGP applies a knowledge transfer mechanism to accelerate convergence. Once a source problem is trained, its non -dominated solutions are extracted and their feature importance is transferred to guide the initialization of another target problem, by which the knowledge generated during the training process can be fully utilized. Experimental results on three sets of instances show that KT-MOGP outperforms the existing GPHH-based method and that the evolved HRs are competitive compared to several classical constructive heuristics and multi -objective evolutionary algorithms. The results also show the effectiveness of the proposed knowledge transfer -based initialization. To the best of our knowledge, this study is the first attempt to consider both multi -objective scenarios and real-time arrival requests.
摘要：
The popular convolutional neural networks (CNN) require data augmentation to achieve rotation invariance. We propose an alternative mechanism, Pre-Rotation Only at Inference stage (PROAI), to make CNN rotation invariant. The overall idea is to learn how the human brain observe images. At the training stage, PROAI trains a CNN with a small number using images only at one orientation. At the inference stage, PROAI introduces a pre-rotation operation to rotate each test image into its all-possible orientations and calculate classification scores using the trained CNN with a small number of parameters. The maximum of these classification scores is able to simultaneously estimate both the category and the orientation of each test image. The specific benefits of PROAI have been experimented on rotated image recognition tasks. The results shows that PROAI improves both the classification and orientation estimation performance while greatly reduced the numbers of parameters and the training time. Codes and datasets are publicly available at
https://github.com/automlresearch/FRPRF
.
期刊：
MATHEMATICAL PROCEEDINGS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY,2024年176(2):287-308 ISSN：0305-0041
通讯作者：
Lim, MF
作者机构：
[Lim, MF; Lim, Meng Fai] Cent China Normal Univ, Sch Math & Stat, 152 Luoyu Rd, Wuhan, Hubei, Peoples R China.;[Lim, MF; Lim, Meng Fai] Cent China Normal Univ, Hubei Key Lab Math Sci, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lim, MF ] C;Cent China Normal Univ, Sch Math & Stat, 152 Luoyu Rd, Wuhan, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Math Sci, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
11R23;11G05;11S25
摘要：
This paper is concerned with the study of the fine Selmer group of an abelian variety over a $\mathbb{Z}_{p}$-extension which is not necessarily cyclotomic. It has been conjectured that these fine Selmer groups are always torsion over $\mathbb{Z}_{p}[[ \Gamma ]]$, where $\Gamma$ is the Galois group of the $\mathbb{Z}_{p}$-extension in question. In this paper, we shall provide several strong evidences towards this conjecture. Namely, we show that the conjectural torsionness is consistent with the pseudo-nullity conjecture of Coates–Sujatha. We also show that if the conjecture is known for the cyclotomic $\mathbb{Z}_{p}$-extension, then it holds for almost all $\mathbb{Z}_{p}$-extensions. We then carry out a similar study for the fine Selmer group of an elliptic modular form. When the modular forms are ordinary and come from a Hida family, we relate the torsionness of the fine Selmer groups of the specialization. This latter result allows us to show that the conjectural torsionness in certain cases is consistent with the growth number conjecture of Mazur. Finally, we end with some speculations on the torsionness of fine Selmer groups over an arbitrary p-adic Lie extension.
期刊：
Microwave and Optical Technology Letters,2024年66(1):e33954- ISSN：0895-2477
通讯作者：
Jin, J
作者机构：
[Ma, Li; Liu, Wei] Tianjin Univ, Sch Microelect, Tianjin, Peoples R China.;[Zhang, Qi-Jun] Carleton Univ, Dept Elect, Ottawa, ON, Canada.;[Jin, Jing] Cent China Normal Univ, Coll Phys Sci & Technol, Wuhan, Peoples R China.;[Zhang, Jianan] Southeast Univ, State Key Lab Millimeter Waves, Nanjing, Peoples R China.
通讯机构：
[Jin, J ] C;Cent China Normal Univ, Coll Phys Sci & Technol, Wuhan, Peoples R China.
关键词：
electromagnetic;finite element method;Padé via Arnoldi;single-size simplification
摘要：
Abstract This paper proposes a new Padé via Arnoldi algorithm with single‐size matrix simplification for electromagnetic (EM) fast frequency sweep. New equations are derived to reduce the double‐size system matrix to single‐size system matrix. We also propose a systematic algorithm to calculate S‐parameters using the simplified single‐size system matrix. Using the proposed algorithm, the EM responses can be obtained with the same accuracy while consuming much less time compared with that using the existing double‐size matrix Padé via Lanczos. The proposed algorithm is demonstrated by two microwave examples.
作者机构：
[Qu, Lianqiang] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China.;[Sun, LQ; Sun, Liuquan] Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China.;[Sun, Yanqing] Univ North Carolina Charlotte, Dept Math & Stat, 9201 Univ City Blvd, Charlotte, NC 28223 USA.
通讯机构：
[Sun, LQ ] C;Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China.
摘要：
Quantile regression has become a widely used tool for analysing competing risk data. However, quantile regression for competing risk data with a continuous mark is still scarce. The mark variable is an extension of cause of failure in a classical competing risk model where cause of failure is replaced by a continuous mark only observed at uncensored failure times. An example of the continuous mark variable is the genetic distance that measures dissimilarity between the infecting virus and the virus contained in the vaccine construct. In this article, we propose a novel mark-specific quantile regression model. The proposed estimation method borrows strength from data in a neighbourhood of a mark and is based on an induced smoothed estimation equation, which is very different from the existing methods for competing risk data with discrete causes. The asymptotic properties of the resulting estimators are established across mark and quantile continuums. In addition, a mark-specific quantile-type vaccine efficacy is proposed and its statistical inference procedures are developed. Simulation studies are conducted to evaluate the finite sample performances of the proposed estimation and hypothesis testing procedures. An application to the first HIV vaccine efficacy trial is provided.
