通讯机构：
[Fanchang Kong] K;Key Laboratory of Adolescent Cyberpsychology and Behavior, Ministry of Education, School of Psychology, Central China Normal University, Wuhan, China
期刊：
International Journal of Human-Computer Interaction,2023年39(17):3324-3333 ISSN：1044-7318
通讯作者：
Qinxue Liu
作者机构：
[Liu, Qinxue; Qiao, Lu; Wu, Jiayin] Cent China Normal Univ, Sch Psychol, Wuhan 430079, Peoples R China.;[Liu, Qinxue] Cent China Normal Univ, Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Peoples R China.;[Liu, Qinxue] Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.
通讯机构：
[Qinxue Liu] S;School of Psychology, Central China Normal University, Wuhan, China<&wdkj&>Key Laboratory of Adolescent Cyberpsychology and Behavior (Central China Normal University), Ministry of Education, Wuhan, China<&wdkj&>Key Laboratory of Human Development and Mental Health of Hubei Province, Wuhan, China
作者机构：
[Zeng, Chengwei; Zhao, Yunjie] Cent China Normal Univ, Inst Biophys, Wuhan 430079, Peoples R China.;[Zeng, Chengwei; Zhao, Yunjie] Cent China Normal Univ, Dept Phys, Wuhan 430079, Peoples R China.;[Jian, Yiren; Vosoughi, Soroush] Dartmouth Coll, Dept Comp Sci, Hanover, NH 03755 USA.;[Zeng, Chen] George Washington Univ, Dept Phys, Washington, DC 20052 USA.
通讯机构：
[Zhao, Yunjie] I;Institute of Biophysics and Department of Physics, Central China Normal University, Wuhan, China
摘要：
RNA-protein complexes underlie numerous cellular processes, including basic translation and gene regulation. The high-resolution structure determination of the RNA-protein complexes is essential for elucidating their functions. Therefore, computational methods capable of identifying the native-like RNA-protein structures are needed. To address this challenge, we thus develop DRPScore, a deep-learning-based approach for identifying native-like RNA-protein structures. DRPScore is tested on representative sets of RNA-protein complexes with various degrees of binding-induced conformation change ranging from fully rigid docking (bound-bound) to fully flexible docking (unbound-unbound). Out of the top 20 predictions, DRPScore selects native-like structures with a success rate of 91.67% on the testing set of bound RNA-protein complexes and 56.14% on the unbound complexes. DRPScore consistently outperforms existing methods with a roughly 10.53–15.79% improvement, even for the most difficult unbound cases. Furthermore, DRPScore significantly improves the accuracy of the native interface interaction predictions. DRPScore should be broadly useful for modeling and designing RNA-protein complexes. RNA-protein docking is a very challenging area. Here, the authors develop a deep-learning based method, DRPScore, to evaluate RNA-protein complexes. DRPScore is robust and consistently performs better than existing methods on representative testing sets.
期刊：
International Journal of Environmental Research and Public Health,2023年20(3):2688- ISSN：1661-7827
通讯作者：
Wei Pan
作者机构：
These authors contributed equally to this work.;Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan 430079, China;Key Laboratory of Human Development and Mental Health of Hubei Province, Wuhan 430079, China;School of Psychology, Central China Normal University, Wuhan 430079, China;Author to whom correspondence should be addressed.
通讯机构：
[Wei Pan] T;These authors contributed equally to this work.<&wdkj&>Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan 430079, China<&wdkj&>Key Laboratory of Human Development and Mental Health of Hubei Province, Wuhan 430079, China<&wdkj&>School of Psychology, Central China Normal University, Wuhan 430079, China<&wdkj&>Author to whom correspondence should be addressed.
摘要：
Depression is one of the most common mental illnesses but remains underdiagnosed. Suicide, as a core symptom of depression, urgently needs to be monitored at an early stage, i.e., the suicidal ideation (SI) stage. Depression and subsequent suicidal ideation should be supervised on social media. In this research, we investigated depression and concomitant suicidal ideation by identifying individuals’ linguistic characteristics through machine learning approaches. On Weibo, we sampled 487,251 posts from 3196 users from the depression super topic community (DSTC) as the depression group and 357,939 posts from 5167 active users on Weibo as the control group. The results of the logistic regression model showed that the SCLIWC (simplified Chinese version of LIWC) features such as affection, positive emotion, negative emotion, sadness, health, and death significantly predicted depression (Nagelkerke’s R2 = 0.64). For model performance: F-measure = 0.78, area under the curve (AUC) = 0.82. The independent samples’ t-test showed that SI was significantly different between the depression (0.28 ± 0.5) and control groups (−0.29 ± 0.72) (t = 24.71, p < 0.001). The results of the linear regression model showed that the SCLIWC features, such as social, family, affection, positive emotion, negative emotion, sadness, health, work, achieve, and death, significantly predicted suicidal ideation. The adjusted R2 was 0.42. For model performance, the correlation between the actual SI and predicted SI on the test set was significant (r = 0.65, p < 0.001). The topic modeling results were in accordance with the machine learning results. This study systematically investigated depression and subsequent SI-related linguistic characteristics based on a large-scale Weibo dataset. The findings suggest that analyzing the linguistic characteristics on online depression communities serves as an efficient approach to identify depression and subsequent suicidal ideation, assisting further prevention and intervention.
作者：
Miao, Tian-Chang;Gu, Chuan-Hua;Liu, Shengyingjie;Zhou, Z. K.*
期刊：
Behaviour & Information Technology,2023年42(11) ISSN：0144-929X
通讯作者：
Zhou, Z. K.
作者机构：
[Miao, Tian-Chang; Gu, Chuan-Hua; Zhou, Z. K.] Cent China Normal Univ, Sch Psychol, Wuhan 430079, Hubei, Peoples R China.;[Miao, Tian-Chang; Gu, Chuan-Hua; Zhou, Z. K.] Cent China Normal Univ, Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Peoples R China.;[Liu, Shengyingjie] Cent China Normal Univ, Natl Engn Res Ctr E Learning, Wuhan, Peoples R China.;[Zhou, Z. K.] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Zhou, Z. K.] C;[Zhou, Z. K.] M;Cent China Normal Univ, Sch Psychol, Wuhan 430079, Hubei, Peoples R China.;Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan 430079, Hubei, Peoples R China.
摘要：
Tian-Chang Miao, Chuan-Hua Gu, Shengyingjie Liu & Z. K. Zhou (2020) Internet literacy and academic achievement among Chinese adolescent: a moderated mediation model, Behaviour & Information Technology, DOI: 10.1080/0144929X.2020.1831074
作者机构：
[Fu, Zhenrong; Zhou, Zongkui] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan, Peoples R China.;[Fu, Zhenrong; Zhou, Zongkui] Cent China Normal Univ, Sch Psychol, Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.;[Zhao, Mingyan] Tangshan Gongren Hosp, Dept Psychol, Tangshan, Peoples R China.;[Li, Yuxia] Tangshan Cent Hosp, Dept Neurol, Tangshan, Peoples R China.;[Han, Ying; Li, Yuxia] Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing, Peoples R China.
通讯机构：
[Han, Y ] C;[Li, SY ] B;Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Haikou 570228, Peoples R China.;Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China.
摘要：
We empirically derived subgroups from the SILCODE SCD cohort using cluster analysis based on eight neuropsychological measures and examined patterns of structural and functional indices of each cluster‐derived subgroup relative to NC. Four SCD subgroups emerged: dysexecutive/mixed, neuropsychiatric, amnestic, and a cluster‐derived normal group. Abstract Aims We evaluated whether Subjective Cognitive Decline (SCD) subtypes could be empirically derived within the Sino Longitudinal Study on Cognitive Decline (SILCODE) SCD cohort and examined associated neuroimaging markers, biomarkers, and clinical outcomes. Methods A cluster analysis was performed on eight neuropsychological test scores from 124 SCD SILCODE participants and 57 normal control (NC) subjects. Structural and functional neuroimaging indices were used to evaluate the SCD subgroups. Results Four subtypes emerged: (1) dysexecutive/mixed SCD (n = 23), (2) neuropsychiatric SCD (n = 24), (3) amnestic SCD (n = 22), and (4) cluster‐derived normal (n = 55) who exhibited normal performance in neuropsychological tests. Compared with the NC group, each subgroup showed distinct patterns in gray matter (GM) volume and the amplitude of low‐frequency fluctuations (ALFF). Lower fractional anisotropy (FA) values were only found in the neuropsychiatric SCD group relative to NC. Conclusion The identification of empirically derived SCD subtypes demonstrates the presence of heterogeneity in SCD neuropsychological profiles. The cluster‐derived normal group may represent the majority of SCD individuals who do not show progressive cognitive decline; the dysexecutive/mixed SCD and amnestic SCD might represent high‐risk groups with progressing cognitive decline; and finally, the neuropsychiatric SCD may represent a new topic in SCD research.
期刊：
COGNITIVE RESEARCH-PRINCIPLES AND IMPLICATIONS,2023年8(1):1-10 ISSN：2365-7464
通讯作者：
Yueh-Hsun Lu
作者机构：
[Zhang, Hanshu] Cent China Normal Univ, Sch Psychol, Wuhan, Hubei, Peoples R China.;[Hung, Shen-Wu; Chen, Yu-Pin] Taipei Med Univ, Wan Fang Hosp, Dept Orthoped, Taipei, Taiwan.;[Chen, Yu-Pin] Taipei Med Univ, Coll Med, Sch Med, Dept Orthoped, Taipei, Taiwan.;[Lu, Yueh-Hsun; Ku, Jan-Wen] Taipei Med Univ, Shuang Ho Hosp, Dept Radiol, 291Zhongzheng Rd, New Taipei City, Taiwan.;[Yang, Cheng-Ta; Tseng, Philip] Taipei Med Univ, Grad Inst Mind Brain & Consciousness, Taipei, Taiwan.
通讯机构：
[Yueh-Hsun Lu] D;Department of Radiology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan<&wdkj&>Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
摘要：
Despite numerous investigations of the prevalence effect on medical image perception, little research has been done to examine the effect of expertise, and its possible interaction with prevalence. In this study, medical practitioners were instructed to detect the presence of hip fracture in 50 X-ray images with either high prevalence (N(signal) = 40) or low prevalence (N(signal) = 10). Results showed that compared to novices (e.g., pediatricians, dentists, neurologists), the manipulation of prevalence shifted participant's criteria in a different direction for experts who perform hip fracture diagnosis on a daily basis. That is, when prevalence rate is low (p(fracture-present) = 0.2), experts held more conservative criteria in answering "fracture-present," whereas novices were more likely to believe there was fracture. Importantly, participants' detection discriminability did not vary by the prevalence condition. In addition, all participants were more conservative with "fracture-present" responses when task difficulty increased. We suspect the apparent opposite criteria shift between experts and novices may have come from medical training that made novices to believe that a miss would result in larger cost compared to false positive, or because they failed to update their prior belief about the signal prevalence in the task, both would suggest that novices and experts may have different beliefs in placing the optimal strategy in the hip fracture diagnosis. Our work can contribute to medical education training as well as other applied clinical diagnosis that aims to mitigate the prevalence effect.
期刊：
Current Psychology,2023年42(36):31724-31735 ISSN：1046-1310
通讯作者：
Zhijin Zhou
作者机构：
[Zhang, Hongpo; Jia, Dandan] Henan Univ Chinese Med, Sch Management, 156 Jinshui Rd Zhengzhou, Zhengzhou 450046, Henan, Peoples R China.;[Wang, Yi; Zhou, Zhijin; Jia, Dandan] Cent China Normal Univ, Sch Psychol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Wang, Yi] Erasmus Univ, Erasmus Sch Social & Behav Sci, Dept Psychol Educ & Child Studies, Burgemeester Oudlaan 50, NL-3062 PA Rotterdam, Zuid Holland, Netherlands.
通讯机构：
[Zhijin Zhou] S;School of Psychology, Central China Normal University, Wuhan, People’s Republic of China
关键词：
Affective Simon Task;Emotion-label word;Emotion-laden word;Emotion words;P100;N170
摘要：
In the field of emotional language research, emotional words have always been the main stimulus for researchers to explore the cognitive mechanisms underlying emotional language processing. In previous studies, most of the emotion-label words (e.g., nausea) and emotion-laden words (e.g., corpse) were collectively referred to as emotion words without distinguishing between the two categories. The main purpose of this study was to explore the emotion effect and cognitive processing mechanism between emotion-label word and emotion-laden word, including two experiments. In experiment 1, An Affective Simon Task was administered to explore the emotion effects of two valence (positive and negative) emotion-label words and emotion-laden words. The results showed that the emotion-label words, regardless of the valence, induced significant Simon effects, while the emotion-laden words only showed Simon effects on the negative valence, which initially proved that the two types of words had different emotional effect. Experiment 2 further explored the cognitive processing mechanism of emotion-label words and emotion-laden words by employing event-related potential (ERP) technology. The ERP data revealed that (1) regardless of the valence, emotion-label words were elicited larger P100 than emotion-laden words and mainly appear in the left posterior sites, (2) regardless of the valence, emotion-laden words elicited larger N170 than emotion-label words, and there was no hemispheric difference, (3) regardless of the valence, emotion-label word and emotion-laden words elicited in similar Late Positivity Complex (LPC) in central sites. According to the current findings, emotion-label words and emotion-laden words had significant differences in emotion effect and cognitive processing. The emotional information in emotion-label words was perceived earlier, while the emotional information in emotion-laden words had stronger physiological activation.
作者机构：
[Xia, Fangjing] Cent China Normal Univ, Sch Psychol, Wuhan 430079, Peoples R China.;[Xia, Fangjing] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan 430079, Peoples R China.;[Liu, Tour; Liu, TR; Xia, Fangjing; Liu, Mengjun] Tianjin Normal Univ, Fac Psychol, Tianjin 300387, Peoples R China.;[Liu, Tour; Liu, TR] Tianjin Normal Univ, Acad Psychol & Behav, Key Res Base Humanities & Social Sci, Minist Educ, Tianjin 300387, Peoples R China.;[Liu, Tour; Liu, TR] Tianjin Social Sci Lab Students Mental Dev & Learn, Tianjin 300387, Peoples R China.
通讯机构：
[Liu, TR ] T;Tianjin Normal Univ, Fac Psychol, Tianjin 300387, Peoples R China.;Tianjin Normal Univ, Acad Psychol & Behav, Key Res Base Humanities & Social Sci, Minist Educ, Tianjin 300387, Peoples R China.;Tianjin Social Sci Lab Students Mental Dev & Learn, Tianjin 300387, Peoples R China.
关键词：
Dark Triad;bullying;coping styles;aggression;gender differences
摘要：
Recently, the phenomenon of school bullying has gradually become a primary focus of social attention. To reduce the occurrence of bullying, it is important that we explore the psychological mechanisms of students with bullying tendencies. We conducted mediation models through a multi-group analysis to verify the mediating effect of coping styles on the relationship between dark personality traits and bullying, and further explored the differences in this mechanism between male and female groups. The participants were 772 high school students recruited from a middle school in Tianjin, China. They completed a set of self-reported measurements including the Dirty Dozen (DD), Simplified Coping Style Questionnaire (SCSQ), Buss-Perry Aggression Questionnaire (BPAQ), and Reactive-Proactive Aggression Questionnaire (RPQ). All the measurement instruments have acceptable reliability and validity. The results of the multi-group multiple models indicated that (1) there are significant gender differences in bullying behavior, with males scoring significantly higher than females. Moreover, the gender difference was only reflected in proactive aggression, in which males had higher scores than females; there was no significant gender difference in reactive aggression. (2) In the group of females, both negative and positive coping styles partially moderated the relationship between the Dark Triad and bullying. However, in the group of males, only negative coping styles partially mediated the relationship between the Dark Triad and bullying. (3) The above results also held for proactive aggression. In conclusion, our study highlights the gender differences in the mediating effect of coping styles on the relationship between the Dark Triad and bullying and proactive aggression. These findings contribute to better shared understanding of gender-related aspects in school bullying.
摘要：
The prevalence of the novel coronavirus (COVID-19) has been considered a major threat to physical and mental health around the world, causing great pressure and mortality threat to most people. The current study aimed to investigate the neurological markers underlying the relationship between perceived mortality threat (PMT) and negative affect (NA). We examined whether the regional amplitude of low-frequency fluctuations (ALFF) and resting-state functional connectivity (RSFC) before the COVID-19 outbreak (October 2019 to December 2019, wave 1) were predictive for NA and PMT during the mid-term of the COVID-19 pandemic (February 22 to 28, 2020, wave 2) among 603 young adults (age range 17-22, 70.8% females). Results indicated that PMT was associated with spontaneous activity in several regions (e.g., inferior temporal gyrus, medial occipital gyrus, medial frontal gyrus, angular gyrus, and cerebellum) and their RSFC with the distributed regions of the default mode network and cognitive control network. Furthermore, longitudinal mediation models showed that ALFF in the cerebellum, medial occipital gyrus, medial frontal gyrus, and angular gyrus (wave 1) predicted PMT (wave 2) through NA (wave 2). These findings revealed functional neural markers of PMT and suggest candidate mechanisms for explaining the complex relationship between NA and mental/neural processing related to PMT in the circumstance of a major crisis.(c) 2023 IBRO. Published by Elsevier Ltd. All rights reserved.
期刊：
SOCIAL BEHAVIOR AND PERSONALITY,2023年51(4) ISSN：0301-2212
作者机构：
[Feng, Junguo; Zhao, Xiuli; Chen, Xiongfei; Ma, Zaoming] South China Normal Univ, Sch Educ, Guangzhou, Peoples R China.;[Zhao, Xiuli] Guangdong AIB Polytech Coll, Acad Art & Design, Guangzhou, Peoples R China.;[Ma, Zaoming] South China Normal Univ, Ctr Southeast Asia Culture & Educ Studies, Guangzhou, Peoples R China.;[Chen, Zhongwei] Guangdong Polytech Sci & Technol, Coll Robot, Guangzhou, Peoples R China.;[Zhang, Libing] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.
关键词：
negative life events;depression;suicide attempts;peer support;adolescents
摘要：
Suicide is a major public health problem among adolescents, and negative life events (NLE) have been considered a significant risk factor for suicide attempts. However, the mediating and moderating processes underlying the relationship between NLE and suicide attempts have remained obscure. We examined both the mediating role of depression and the moderating role of peer support underlying this relationship. The results showed that depression fully mediated the positive relationship between NLE and adolescent suicide attempts. A moderated mediation analysis further revealed that the indirect path from NLE to suicide attempts was moderated by peer support. These findings suggest that the development of depression plays a key role in explaining why adolescents who have experienced NLE are at a greater risk of suicide attempts than those who have not. A healthy peer support system could serve as a buffer to reduce the adverse outcomes resulting from NLE. Overall, the results may contribute to developing an integrative framework of theory and effective interventions.
期刊：
Children and Youth Services Review,2023年152:107084 ISSN：0190-7409
通讯作者：
He, D;He, Dan;Li, XP
作者机构：
[He, Dan] Cent China Normal Univ, Sch Psychol, Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan 430079, Peoples R China.;[He, Dan; Li, Xue-Ping] China West Normal Univ, Coll Presch & Primary Educ, Nanchong 637000, Peoples R China.;[Liu, Qing-Qi] Beijing Normal Univ, Coll Educ Future, Zhuhai 519087, Peoples R China.;[Li, Xue-Ping; He, D] China West Normal Univ, Coll Presch & Primary Educ, Nanchong 637000, Peoples R China.;[He, D] Cent China Normal Univ, Sch Psychol, Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan 430079, Peoples R China.
通讯机构：
[Li, XP ; He, D; He, D ] ;Cent China Normal Univ, Sch Psychol, Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan 430079, Peoples R China.;China West Normal Univ, Coll Presch & Primary Educ, Nanchong 637000, Peoples R China.
关键词：
Adolescents;Cyberbullying;Parental conflict;Perceived social support;Social anxiety
期刊：
International Journal of Environmental Research and Public Health,2023年20(2):1105- ISSN：1661-7827
通讯作者：
Junmei Xiong
作者机构：
[Xiong, Junmei; Xie, Weiwei; Zhang, Tong] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan 430079, Peoples R China.;[Xiong, Junmei; Xie, Weiwei; Zhang, Tong] Cent China Normal Univ, Sch Psychol, Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan 430079, Peoples R China.;[Xiong, Junmei; Xie, Weiwei; Zhang, Tong] Cent China Normal Univ, Sch Psychol, Wuhan 430079, Peoples R China.
通讯机构：
[Junmei Xiong] K;Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan 430079, China<&wdkj&>School of Psychology, Central China Normal University, Wuhan 430079, China<&wdkj&>Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan 430079, China<&wdkj&>Author to whom correspondence should be addressed.
关键词：
dual-factor model of mental health;cumulative risk;coping style;gratitude;left-behind children in China
摘要：
Based on the dual-factor model of mental health (DFM) and the cumulative risk (CR) model, this study aimed to investigate the impact of CR on left-behind children's mental health and the underlying mechanism involved, specifically the mediating role of coping style and the moderating role of gratitude in the relationship between CR and mental health. The random cluster sampling method was applied to collect data on CR, coping style, gratitude, life satisfaction, and depression from 705 left-behind children (374 boys, M-age = 12.20 +/- 1.25). The moderated mediation analyses indicated that: (1) the moderated mediation model of CR and depression was significant: coping style mediated the relationship between CR and depression, and gratitude moderated this mediating effect with gratitude strengthening the negative association between CR and coping style; and (2) gratitude moderated the relationship between CR and life satisfaction and it also strengthened the negative association between CR and life satisfaction. The findings suggest that the mechanisms of coping style may differ in the relationships between CR and positive and negative indicators of mental health in left-behind children and that gratitude as a protective factor has limited capacity to buffer the negative effect of accumulated risk. These findings provide evidence for differentiated intervention approaches to promote disadvantaged children's life satisfaction and depression.
期刊：
Journal of Hazardous Materials,2023年457:131837 ISSN：0304-3894
通讯作者：
Lu, C
作者机构：
[Liu, Zijing; Yang, Wenhui; Lu, Chan; Liao, Hongsen] Cent South Univ, XiangYa Sch Publ Hlth, Changsha 410078, Hunan, Peoples R China.;[Wang, Faming] Katholieke Univ Leuven, Dept Biosyst, Div Anim & Human Hlth Engn, B-3001 Leuven, Belgium.;[Wang, Faming] Xian Univ Sci & Technol, Occupat Safety & Publ Hlth Grp, Xian 710054, Shanxi, Peoples R China.;[Li, Bin] Cent China Normal Univ, Sch Psychol, Wuhan 430070, Hubei, Peoples R China.
通讯机构：
[Lu, C ] C;Cent South Univ, XiangYa Sch Publ Hlth, Changsha 410078, Hunan, Peoples R China.
关键词：
Childhood pneumonia;Gaseous air pollution;Particulate matters;Postnatal;Pregnancy
摘要：
BACKGROUND: Despite mounting evidence linked pneumonia with air pollution, it is unclear what main pollutant(s) exposure in which critical window(s) play a key role in pneumonia. OBJECTIVE: To examine effects of intrauterine and post-natal exposure to air pollution on children's doctor-diagnosed pneumonia (DDP). METHODS: A combination of cross-sectional and retrospective cohort study was conducted at Changsha, China during 2019-2020. Personal exposure to outdoor air pollutants at each child's home address was estimated using inverse distance weighted (IDW) method based on data from 10 air quality monitoring stations. Associations between personal air pollution exposure and DDP were evaluated. RESULTS: Children's DDP was associated with intrauterine and post-natal exposure to PM(2.5), PM(2.5-10), and PM(10), adjusted ORs (95% CI) of 1.17 (1.04-1.30), 1.09 (1.01-1.17), and 1.07 (1.00-1.14) for IQR increase in intrauterine exposure and 1.12 (1.02-1.22), 1.13 (1.06-1.21), and 1.28 (1.16-1.41) for post-natal exposure. Intrauterine PM(2.5) exposure and post-natal PM(10) exposure were associated with a higher risk of pneumonia. We identified the 2nd trimester, 3rd trimester, and first year as critical windows respectively for PM(2.5), PM(2.5-10), and PM(10) exposure. Daytime exposure to traffic-related air pollution especially during early life increased DDP. CONCLUSION: Intrauterine and post-natal exposure to particulate matters played a dominant role in children's DDP.
