期刊：
Pesticide Biochemistry and Physiology,2024年199:105769 ISSN：0048-3575
通讯作者：
Sun, Y;Zhang, AD
作者机构：
[Zhou, Yaqing; Wang, Jili; Sun, Yong; Sun, Y; Zhou, Xin; Wu, Wenhai] Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.;[Zhang, Aidong; Han, Mengying] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Zhang, AD ] C;[Sun, Y ] H;Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
The discovery of safe, effective, and selective chemical algicides is the stringent need for the algicides development, and it is also one of the effective routes to control cyanobacteria harmful algal blooms and to meet the higher requirements of environmental and ecological. In this work, a series of novel bromo-N-phenyl-5-ohydroxyphenylpyrazole-3-carboxyamides were rationally designed as pseudilin analogs by bioisosteric replacement and molecular hybridization strategies, in which the pyrrole unit of pseudilin was replaced with pyrazole and further combined with the dominant structural fragments of algicide diuron. The synthesis was carried out by a facile four-step routeincluding cyclization, amidation, transanulation, and halogenation. The biological activity evaluation on AtIspD, EcIspD, Synechocystis sp. PCC6803 and Microcystis aeruginosa FACHB905 revealed that most compounds had good EcIspD and excellent cyanobacteria inhibitory activity. In particular, compound 6bb exhibited potent algicidal activity against PCC6803 and FACHB905 with EC50 = 1.28 mu M and 0.37 mu M, respectively, 1.4-fold and 4.0-fold enhancement compared to copper sulfate (EC50 = 1.79 and 1.49 mu M, respectively), and it also showed the best inhibitory activity of EcIspD. The binding of 6bb to EcIspD was explored by molecular docking, and it was confirmed that 6bb could bind to the EcIspD active site. Compound 6bb was proven to be a potential structure for the further development of novel algicides that targets IspD in the MEP pathway.
摘要：
Fosmidomycin (FOS) is a natural product inhibiting the DXR enzyme in the MEP pathway and has stimulated interest for finding more suitable FOS analogues. Herein, two series of FOS analogue hydroxamate-containing bisphosphonates as proherbicides were designed, with bisphosphonate replacing the phosphonic unit in FOS while retaining the hydroxamate (BPF series) or replacing it with retro-hydroxamate (BPRF series). The BPF series were synthesized through a three-step reaction sequence including Michael addition of vinylidenebisphosphonate, N-acylation, and deprotection, and the BPRF series were synthesized with a retro-Claisen condensation incorporated into the reaction sequence. Evaluation on model plants demonstrated several compounds having considerable herbicidal activities, and in particular, compound 8m exhibited multifold activity enhancement as compared to the control FOS. The proherbicide properties were comparatively validated. Furthermore, DXR enzyme assay, dimethylallyl pyrophosphate rescue, and molecular docking verified 8m to be a promising proherbicide candidate targeting the DXR enzyme. In addition, 8m also displayed good antimalarial activities.
通讯机构：
[Zhang, AD ] C;Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
We report herein a dynamic facet-selective capping (dFSC) strategy for α-calcium sulfate hemihydrate crystal growth from dihydrate gypsum in the presence of a catechol-derived PEI capping agent (DPA-PEI) with inspiration by the biomineralization process of mussel. The crystal shape is controllable and varies from long and pyramid-tipped prisms to thin hexagonal plate. The highly uniform truncated crystals have extremely high compression and bending strengths after hydration molding.
期刊：
Chemical Papers,2023年77(11):6763-6771 ISSN：2585-7290
通讯作者：
Sun, Y;Zhang, AD
作者机构：
[Zhou, Ya-Qing; Sun, Yong; Wang, Ji-Li; Sun, Y; Wu, Wen-Hai] Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.;[Zhang, Aidong; Duan, Jiang] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Zhang, AD ] C;[Sun, Y ] H;Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
关键词：
Aqueous film-forming foam;Formulation;Short-chain perfluorinated surfactant;Extinguishing time;Burnback time
摘要：
As the essential component(s), long-chain perfluorinated or short-chain perfluorinated ionic surfactants are required for effective aqueous film-forming foam (AFFF); nevertheless, the associated qualities of persistent pollution and toxicity have raised significant concerns. It has become critical to develop alternatives to the present fluorine component for AFFF to offset the negative effects. In this study, a short-chain perfluorinated nitrogen-heterocyclic nonionic amine oxide surfactant was combined with hydrocarbon surfactants and additives to prepare an AFFF concentrate. A laboratory technique was developed to evaluate the influence of ingredients on the performance of a 6% AFFF diluent, resulting in an improved AFFF formulation. The performance parameters for pool fire extinguishment and fire resistance of the AFFF formulation were encouraging, including a spreading coefficient of 5.4, foam expansion of 8.11, 25% drainage time of 4.6 min, extinguishing times for forceful application of 58 s, and fire burnback time of 18.6 min. In addition, the AFFF concentrate showed significant freezing resistance when stored at - 20 & DEG;C for an extended period of time. The formulation outperformed the technical standard criteria and has the potential to be used as a novel AFFF agent. [GRAPHICS]
摘要：
A compact 4-port coplanar waveguide (CPW) fed ultra-wideband (UWB) multiple-input-multiple-output (MIMO) antenna with enhanced isolation is proposed to operate from 3.66 GHz to 16.61 GHz with 127.78% impedance bandwidth. The proposed antenna system consists of 4 orthogonal arrays of monopole antennas improved by four iterations. The UWB characteristic of the antenna is obtained from an improved monopole antenna fed by CPW. The final MIMO antenna is machined on a Rogers 4003C substrate with dimensions of 60 x 60 x 0.3 mm(3). The orthogonal arrangement of antennas brings about the polarization diversity and certain isolation of MIMO antennas. Four rows of orthogonal metasurface elements with via holes and the ring of the backplane further improve the isolation between antenna elements in the MIMO system. The MIMO antenna has an impedance bandwidth of 12.95 GHz with S-11 < -10 dB and good isolation (S-21 =S-41 < -30 dB and S-31 < -20 dB). In particular, S31 is always less than -25 dB at frequencies greater than 6 GHz. The measured results of MIMO antenna agree with the simulated results. The optimized MIMO antenna has excellent performance in many aspects, such as UWB, compact size, omnidirectional radiation, enhanced isolation and high efficiency, which means that it has application potential in UWB wireless communication systems.
摘要：
Fosmidomycin (FOS) is a naturally occurring compound that is active against the 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) enzyme in the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, and using it as a template for lead structure design is an effective strategy to develop new active compounds. In this work, by replacing the hydroxamate unit of FOS with pyrazole, isoxazole and the related heterocycles that also have metal ion binding affinity, while retaining the monophosphonic acid in FOS or replacing it with a bisphosphonic acid group, heterocycle-containing mono- and bisphosphonic acid compounds such as FOS analogs were designed. The key steps involved in the facile synthesis of these FOS analogs include the Michael addition of diethyl vinylphosphonate or tetraethyl vinylidenebisphosphonate to β-dicarbonyl compounds and the subsequent cyclic condensation with hydrazine or hydroxylamine. Two additional isoxazolinone-bearing FOS analogs were synthesized via the Michaelis–Becker reaction with diethyl phosphite as a key step. The bioactivity evaluation on model plants demonstrated that several compounds have better herbicidal activities compared to FOS, with the most active compound showing a 3.7-fold inhibitory activity on Arabidopsis thaliana, while on the roots and stalks of Brassica napus L. and Echinochloa crus-galli in a pre-emergence inhibitory activity test, the activities of this compound were found to be 3.2- and 14.3-fold and 5.4- and 9.4-fold, respectively, and in a post-emergency activity test on Amaranthus retroflexus and Echinochloa crus-galli, 2.2- and 2.0-fold inhibition activities were displayed. Despite the significant herbicidal activity, this compound exhibited a DXR inhibitory activity lower than that of FOS but comparable to that of other non-hydroxamate DXR inhibitors, and the dimethylallyl pyrophosphate rescue assay gave no statistical significance, suggesting that a different target might be involved in the inhibiting process. This work demonstrates that using bioisosteric replacement can be considered as a valuable strategy to discover new FOS analogs that may have high herbicidal activities.
期刊：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS,2023年198(5):446-452 ISSN：1042-6507
通讯作者：
Aidong Zhang
作者机构：
[Ping, Hongrui; Song, Chunlin; Duan, Jiang; Wu, Xin; Zhang, Aidong] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan, Hubei, Peoples R China.;[Zhang, Aidong] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Aidong Zhang] K;Key Laboratory of Pesticides & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei, China
摘要：
Fosmidomycin and its acetyl analogue FR900098 are two phosphorus-containing natural products with inhibitory activity against IspC enzyme in the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway of isoprenoid biosynthesis in plants and most bacteria. This work presents a facile route for the chemical synthesis of fosmidomycin and FR900098 using readily available raw materials. Through optimizing reaction conditions of the key steps of Michaelis-Becker reaction and acylation, the monosodium salts of fosmidomycin and FR900098 were obtained in yields of 60% and 66%, respectively, over six steps in the route. This unified route provides an alternative to the reported methods and makes it possible to synthesize the two valuable compounds with scalability and low cost, having the potential for application in developing new antimalarial drugs and pesticides.
作者机构：
[Li, Yujun; Li, Shangru; Yang, Helin; Jin, Jing; Yang, Yuejie] Cent China Normal Univ, Coll Phys Sci & Technol, Wuhan 430079, Peoples R China.;[Huang, Xiaojun] Xian Univ Sci & Technol, Coll Commun & Informat Engn, Xian 710054, Peoples R China.;[Zhang, Aidong] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Helin Yang] C;College of Physical Science and Technology, Central China Normal University, Wuhan 430079, China
关键词：
Effective medium theory;Material properties;Polarization;Reflection coefficient;Subwavelength structures;Transparency
摘要：
A multifunctional metamaterial to realize broadband x-to-y cross-polarization conversion (CPC) and the absorption of electromagnetic waves is proposed in this paper. The presented multifunctional water-based metamaterial (MWM) consists of the top metallic dielectric substrate, the middle 3D printed container, and the bottom metal backplane. When the container is filled with water, the polarization conversion ratio (PCR) reaches more than 90% at 5.8-9.4 GHz, and the excellent absorption performance is achieved in the frequency band of 16.1-16.9 GHz. In addition, the CPC is achieved in two frequency bands (5.9-10.0 GHz and 14.3-16.4 GHz) without water injection. The unique properties of the proposed design are validated by experiments. As expected, the MWM simultaneously achieves polarization conversion and absorption functions, which is meaningful and consequential for multifunction and conformal stealth applications.
摘要：
A leaky-Vivaldi antenna covered with metasurface (LVAM) is proposed in this paper. The traditional Vivaldi antenna covered with metasurface realizes backward frequency beam-scanning from -41 & DEG; to 0 & DEG; in the high-frequency operating band (HFOB) and retains aperture radiation in the low-frequency operating band (LFOB). In the LFOB, the metasurface can be regarded as a transmission line to realize a slow-wave transmission. In the HFOB, the metasurface can be considered a 2D periodic leaky-wave structure to realize a fast-wave transmission. The simulated results show that LVAM has the-10 dB return loss bandwidths of 46.5% and 40.0%, and the realized gain of 8.8-9.6 dBi and 11.8-15.2 dBi cover the 5 G Sub-6 GHz band (3.3-5.3 GHz) and the X band (8.0-12.0 GHz), respectively. The test results are in good agreement with the simulated results. As a dual-band antenna covering the 5 G Sub-6 GHz communication band and military radar band, the proposed antenna can guide the future integrated design of communication and radar antenna systems. & COPY; 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
摘要：
In this paper, a polarization-sensitive absorption and transmission polarization conversion multifunctional metasurface is designed. Based on the principle of Fabry-Borot antenna, the modulation of electromagnetic waves with different polarizations is realized. Receiver-transmitter structure consisting of rectangular metal patches on the front and back sides . Cross-polarization conversion of Y-polarized waves was achieved at 8.9-15.2 GHz. In combination with the open-slit elliptical structure, selective absorption of X-polarization can be achieved, thus realizing the radar cross-section(RCS) reduction of the target. The absorption operates in the frequency band of 8.3-13.9 GHz. Electromagnetic waves of different polarizations do not affect each other in the modulation of the same structure and operate in almost the same frequency band. To verify the proposed structure, the relevant parameters were optimized and measured. The experimental results match with the simulation results, and the design can be used for radome and electromagnetic stealth.
期刊：
FRONTIERS IN CHEMISTRY,2022年10:975267 ISSN：2296-2646
通讯作者：
Zhang, A.-D.;Wang, X.;Luo, X.-P.;Kuang, Y.
作者机构：
[Luo, Xi-Ping; Miu, Jian-Xin; Wang, Yu-Xuan; Kuang, Yi; Wang, Xing; Han, Wen-Qing] Zhejiang A&F Univ, Coll Chem & Mat Engn, Zhejiang Prov Key Lab Chem Utilizat Forestry Bioma, Hangzhou, Peoples R China.;[Luo, Mu-Jia] Jiangxi Sci & Technol Normal Univ, Key Lab Organ Chem Jiangxi Prov, Nanchang, Peoples R China.;[Zhang, Ai-Dong] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Peoples R China.
通讯机构：
[Wang, X.; Luo, X.-P.; Kuang, Y.] Z;[Zhang, A.-D.] K;Key Laboratory of Pesticide Chemical Biology of the Ministry of Education, China;Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, China
作者机构：
[Kuang Y.; Li Y.S.; Yang S.X.; Wang X.; Chen Z.H.; Chen W.; Luo X.P.] Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, Zhejiang A & F University, Zhejiang, Lin’an, 311300, China;[Luo M.J.] Key Laboratory of Organic Chemistry of Jiangxi Province, Jiangxi Science & Technology Normal University, Nanchang, 330013, China;[Zhang A.D.] Key Laboratory of Pesticide & Chemical Biology of the Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, China
通讯机构：
[Wang, X.] Z;Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, Zhejiang, China
作者机构：
[Rao, Li; Mei, Caihong; Duan, Jiang; Wu, Wenli; Zhang, Aidong] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.;[Fan, Heping] Haiso Technol Co Ltd, Wuhan 430074, Peoples R China.;[Tang, Yiwen] Cent China Normal Univ, Coll Phys Sci & Technol, Wuhan 430079, Peoples R China.
通讯机构：
[Aidong Zhang] C;College of Chemistry, Central China Normal University, Wuhan 430079, China
摘要：
This work presents a strategy for fabricating low dielectric epoxy copolymers through copolymerizing bisphenol A diglycidyl ether with N,N'-disilyl bis(secondary amine)s, a series of difunctional silylamines synthesized by silylation of bis(secondary amine)s. A study on the model reaction of monoepoxy with monofunctional silylamines identified that the reaction proceeded smoothly in tetrahydrofuran with Mg(ClO4)(2) catalysis and mechanistically through sequential silylamine-induced epoxy ringopening and silylotropic N -> O migration, a process with favorable Gibbs free energy changes as confirmed by density functional theory calculations. The copolymers demonstrated remarkably low dielectric constants and dielectric losses due to the formation of the low-polarizable silyloxyl instead of the hydroxyl group in polymerization and the enlarged molecular free volume. In addition, the copolymers showed desirable toughness, hydrophobicity, and thermal stability. As a tool to achieve these desirable features, the strategy developed in this work may find promising application in designing low dielectric epoxy resin materials for use in the microelectronic field.
摘要：
Long-chain perfluorocarbon surfactants are indispensible for use in many fields but restricted in production and application due to environmental concerns such as their bioaccumulation, non-degradation and high toxicity, making the development of new alternative surfactants an urgent need. In this article, a series of short-chain perfluorocarbon-containing surfactants were designed and synthesized, featuring the structural components of short-chain perfluoroalkylsulfonate, phenylmethyl linker, and N-heterocylic cation. These surfactants exhibit aqueous surface tensions ranging from 17 to 34 mN/m, comparable to that of similar long-chain counterparts. In addition, a formulation that contains one of the synthesized surfactants are capable of forming a type of partitioning film on liquid hydrocarbons such as cyclohexane, significantly suppressing the evaporation loss under ambient conditions to less than 20% during a testing period of 30 h. The results suggest that the formulations composed of these short-chain perfluorocarbon surfactants are applicable as promising evaporation suppressors in the field of petroleum storage and transportation.
摘要：
The advent of electronic noses opened a new kind of analytical approach, which offers an easy, quick, and cheap measurement comparing to conventional analytical approaches. It has potential applications on many different fields, such as assessment of various foodstuffs and beverages, environmental contamination monitoring and medical diagnostics etc. In this study, we used odorant binding protein (OBP) as odor-sensing material for developing such kind of artificial odorant biosensor. And biological films of OBP-1F (rat OBP) were deposited by Langmuir-Blodgett (LB) technique on gold electrode previously functionalised with 1-octadecanethiol (ODT) by self-assembled monolayers (SAMs). It is known that successful immobilization of the Langmuir-Blodgett films depends strongly on the characteristics, particularly stability, of the corresponding Langmuir films at the air/water interface. Hence the characteristics of monolayer of amphiphile octadecylamine (ODA) and the mixed monolayer of ODA/OBP were studied. Electrochemical impedance spectroscopy (EIS) was used to monitor the response of the system to a specific odorant molecule, isoamyl acetate.
