A red to near-infrared fluorescent probe featuring a super large Stokes shift for light-up detection of endogenous H2S
作者：
Hong, Jiaxin;Zhou, Enbo;Gong, Shengyi;Feng, Guoqiang*
期刊：
Dyes and Pigments ,2019年160:787-793 ISSN：0143-7208
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Hong, Jiaxin; Gong, Shengyi; Zhou, Enbo] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Dicyanoisophorone;Fluorescent imaging;H2S;Large Stokes shift;NIR fluorescent probe
摘要：
In this work, a new reaction-based red to near-infrared (NIR) fluorescent turn-on probe for H2S was developed. This probe uses a readily prepared dicyanoisophorone as the fluorophore and a 2, 4-dinitrobenzenether with an ortho-aldehyde group as the reaction site. Upon addition of H2S, a fast nucleophilic addition of H2S to the aldehyde group and a following efficient intramolecular thiolysis of dinitrophenyl ether occurred, which leads to release the fluorophore and give a rapid NIR fluorescence turn-on response for H2S with a super large Stokes shift (244 nm). The fluorescence enhancement was found up to 105-fold and the detection limit was determined to be as low as 42 nM. Importantly, this probe shows high selectivity and sensitivity for H2S without interference from biothiols. Furthermore, NIR fluorescent imaging of exogenous and endogenous H2S in living cells with this probe was also successfully applied. All the results indicate that this probe is excellent and highly valuable. © 2018 Elsevier Ltd
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英文
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Iminocoumarin-based red to near-infrared fluorescent turn-on probe with a large Stokes shift for imaging H2S in living cells and animals
作者：
Feng, Shumin;Xia, Qingfeng;Feng, Guoqiang*
期刊：
Dyes and Pigments ,2019年163:447-453 ISSN：0143-7208
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Xia, Qingfeng; Feng, Shumin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Hydrogen sulfide;Iminocoumarin;Large Stokes shift;Living cells and animals;Near-infrared fluorescent probe
摘要：
The development of organic dye-based fluorescent probes for detection of H2S in living systems has attracted considerable attention in recent years. In this work, a novel tetrahydroquinoxaline iminocoumarin-based red to near-infrared (red-to-NIR) fluorescent probe was developed for detection of H2S. This probe shows a rapid and distinct red-to-NIR fluorescent turn-on detection process for H2S with high selectivity and sensitivity (the detection limit was determined to be as low as 10 nM at physiological pH). In addition, this probe exhibits a remarkable large Stokes shift (128 nm) and low cytotoxicity, and can be applied for imaging H2S in living cells and animals. All these results demonstrated that this new probe is promising for detection of H2S both in vitro and in vivo. © 2018 Elsevier Ltd
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英文
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CO release with ratiometric fluorescence changes: a promising visible-light-triggered metal-free CO-releasing molecule
作者：
Feng, Weiyong;Feng, Shumin;Feng, Guoqiang*
期刊：
Chemical Communications ,2019年55(61):8987-8990 ISSN：1359-7345
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Feng, Weiyong; Feng, Shumin] Cent China Normal Univ, Coll Chem, Chem Biol Ctr, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Chem Biol Ctr, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
The first visible-light-triggered metal-free and ratiometric fluorescent CORM is reported. This CORM can be used to release CO with distinct ratiometric fluorescence changes in aqueous solution, living cells, zebrafish, and mice, which provided an excellent controllable and trackable CORM for living systems.
语种：
英文
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An ultrasensitive fluorescent probe for phosgene detection in solution and in air
作者：
Bai, Luoyi;Feng, Weiyong;Feng, Guoqiang*
期刊：
Dyes and Pigments ,2019年163:483-488 ISSN：0143-7208
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Bai, Luoyi; Feng, Weiyong] Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
AIE;ESIPT;Fluorescent probe;HBT;Phosgene;Portable sensing system
摘要：
In this work, an ultrasensitive fluorescent turn-on probe (HBT-Phos) for rapid detection of the highly toxic phosgene is reported. This probe uses 2-(2′-hydroxyphenyl)benzothiazole (HBT), a well-known excited-state intramolecular proton transfer (ESIPT) dye as the fluorophore and an oxime moiety as the reaction site. Upon addition of various analytes, this probe specifically reacts with phosgene to release a highly fluorescent nitrile product (HBT-CN) via a dehydration process, which provides a new selective and ultrasensitive fluorescent turn-on detection method for phosgene (F/F0 ∼1750-fold, detection limit ∼0.48 nM in solution). Furthermore, using the aggregation-induced emission (AIE) of the product in solid state, this probe was successfully applied to prepare a silica plate-based portable sensing system for detecting phosgene gas in air with a detection limit as low as ∼0.34 ppm. All the results indicate that this probe is of great value for on-site detection of phosgene. © 2018 Elsevier Ltd
语种：
英文
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Development of a near-infrared fluorescent sensor with a large Stokes shift for sensing pyrophosphate in living cells and animals
作者：
Yang, Shengjun;Feng, Weiyong;Feng, Guoqiang*
期刊：
Analytica Chimica Acta ,2018年1034:119-127 ISSN：0003-2670
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Feng, Weiyong; Yang, Shengjun] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Hubei Int Sci & Technol Cooperat Base Pesticide &, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Hubei Int Sci & Technol Cooperat Base Pesticide &, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.
关键词：
Bioimaging;In vitro and in vivo detection;Large Stokes shift;Near-infraredfluorescent sensor;Pyrophosphate
摘要：
The detection of pyrophosphate (PPi) in living systems has attracted considerable attention in recent years due to its biological significance. While many fluorescent PPi sensors were developed with emission changes in the visible region, near-infrared (NIR) fluorescent sensors for PPi are rather scarce. In this paper, a dicyanomethylene-benzopyran (DCMB) based phenol-bridged dinuclear Zn(II)-DPA (DPA: dipicolylamine) complex was prepared, which was found to be a promising NIR fluorescent sensor for PPi. This sensor features a remarkable large Stokes shift (>150 nm) and shows colorimetric and NIR fluorescence changes for PPi with high selectivity and sensitivity in 100% aqueous solution. The detection limit of this sensor for PPi was determined to be as low as 42 nM. In addition, this sensor exhibits low cytotoxicity and can be conveniently employed for bioimaging PPi in living cells and animals, indicating it has great potential for in vitro and in vivo detection of PPi. © 2018 Elsevier B.V.
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英文
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Umpolung of Imines Enables Catalytic Asymmetric Regio-reversed [3+2] Cycloadditions of Iminoesters with Nitroolefins
作者：
Feng, Bin;Lu, Liang-Qiu;Chen, Jia-Rong;Feng, Guoqiang;He, Bin-Qing;...
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ,2018年57(20):5888-5892 ISSN：1433-7851
通讯作者：
Xiao, Wen-Jing
作者机构：
[Feng, Guoqiang; Feng, Bin; Lu, Liang-Qiu; Lu, Bin; He, Bin-Qing; Xiao, Wen-Jing; Chen, Jia-Rong] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, CCNU uOttawa Joint Res Ctr,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Xiao, Wen-Jing] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, CCNU uOttawa Joint Res Ctr,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
chiral ligands;cycloaddition;imines;nitroolefins;umpolung
摘要：
A copper-catalyzed regio-reversed asymmetric [3+2] cycloaddition of iminoesters with nitroolefins is disclosed for the first time. This method enables the facile synthesis of polysubstituted chiral pyrrolidines bearing at least one chiral quaternary center in high yields with excellent regio-, diastereo-, and enantioselectivity. The application of chiral P,S ligands and the unique effect of α-aryl groups on the iminoesters are key to the success of this method. The practicality and versatility of the reaction are also demonstrated. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
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A readily available colorimetric and near-infrared fluorescent turn-on probe for detection of carbon monoxide in living cells and animals
作者：
Feng, Weiyong;Feng, Guoqiang*
期刊：
Sensors and Actuators B-Chemical ,2018年255(Pt.2):2314-2320 ISSN：0925-4005
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Feng, Weiyong] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Carbon monoxide;Colorimetric;Near-infrared fluorescent probe;In vitro and in vivo;Living cells and animals
摘要：
Since carbon monoxide (CO) was recognized as an important gasotransmitter, great interest has been given to develop probes for detection of this gas molecule in living systems. While several fluorescent probes have been developed very recently for imaging CO in living cells, probes for in vivo detection of CO have not yet been reported. Herein, we report a new NIR fluorescent CO probe that can be used for detection of CO both in vitro and in vivo. This probe works in almost wholly aqueous solution under mild conditions and shows high selectivity and sensitivity for CO in the presence of Pd2+, giving rapid (within few minutes) and distinct colorimetric and near-infrared (NIR) fluorescent turn-on signal changes with a detection limit as low as 3.2 nM. Moreover, we also show that this probe has low cytotoxicity and can be conveniently used to image CO in both living cells and animals. (C) 2017 Elsevier B.V. All rights reserved.
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英文
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A rapid responsive colorimetric and near-infrared fluorescent turn-on probe for imaging exogenous and endogenous peroxynitrite in living cells
作者：
Liu, Dandan;Feng, Shumin;Feng, Guoqiang*
期刊：
Sensors and Actuators B-Chemical ,2018年269:15-21 ISSN：0925-4005
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Liu, Dandan; Feng, Shumin] Cent China Normal Univ, Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
NIR fluorescent probe;Peroxynitrite (ONOO-);Colorimetric;Bioimaging;Exogenous and endogenous
摘要：
Rapid, specific and sensitive near-infrared (NIR) fluorescent probes for endogenous peroxynitrite (ONOO<sup>−</sup>) are valuable tools for the research of ONOO<sup>−</sup>in living systems. In this paper, we developed a new colorimetric and NIR fluorescent turn-on probe for ONOO<sup>−</sup>by using a NIR fluorescent chromenylium-cyanine hybrid as the fluorophore and a hydrazide as the reactive site. This probe exhibits prominent features during detecting ONOO<sup>−</sup>including rapid response (<2 s), high selectivity and sensitivity, long excitation wavelength (640 nm), distinct colorimetric (colorless to blue) and significant NIR fluorescent turn-on signal changes as well as low cytotoxicity. The fluorescence enhancement at 698 nm is more than 100-fold and the detection limit is as low as 25 nM for ONOO<sup>−</sup>. We also showed that this probe could be used for bioimaging of both exogenous and endogenous peroxynitrite in living cells, indicating it can be used as a powerful tool for the biological research of peroxynitrite in living systems.<br/> ©2018 Elsevier B.V.
语种：
英文
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Readily prepared iminocoumarin for rapid, colorimetric and ratiometric fluorescent detection of phosgene
作者：
Feng, Weiyong;Gong, Shengyi;Zhou, Enbo;Yin, Xinyu;Feng, Guoqiang*
期刊：
Analytica Chimica Acta ,2018年1029:97-103 ISSN：0003-2670
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Gong, Shengyi; Feng, Weiyong; Yin, Xinyu; Zhou, Enbo] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Colorimetric;Fluorescent probe;Iminocoumarin;Paper test strips;Phosgene;Ratiometric
摘要：
In this paper, a new colorimetric and ratiometric fluorescent probe for the rapid detection of phosgene is reported. This probe is based on a readily prepared and highly fluorescent iminocoumarin, which reacts rapidly with phosgene to form a cyclic carbamate product to produce, distinctive colorimetric and ratiometric fluorescent signal changes. The detection of phosgene with this probe is fast (complete within 2 min), highly selective and sensitive with a detection limit of 27 nM in solution. Moreover, this probe can be used to prepare easy-to-use paper test strips for convenient visual and fluorescent detection of phosgene gas even at a concentration of 0.1 mg/L. Overall, this work provides a very promising dual colorimetric and ratiometric fluorescent probe for rapid and sensitive detection of phosgene both in solution and in the gas phase. © 2018 Elsevier B.V.
语种：
英文
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Rapid and selective detection of selenocysteine with a known readily available colorimetric and fluorescent turn-on probe
作者：
Zhang, Haiyan;Li, Meixing;Feng, Weiyong;Feng, Guoqiang*
期刊：
Dyes and Pigments ,2018年149:475-480 ISSN：0143-7208
通讯作者：
Feng, Guoqiang
作者机构：
[Zhang, Haiyan] Wuhan Polytech Univ, Sch Chem & Environm Engn, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.;[Feng, Guoqiang; Feng, Weiyong; Li, Meixing] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Colorimetric;Fluorescent probe;Living cells;Selenocysteine;Serum
摘要：
Selenocysteine (Sec) is known as the 21st amino acid that is incorporated into selenoproteins (SePs) and plays vital roles in living systems. Accordingly, development of fluorescent detection method for Sec is of significance. Herein, a readily available fluorescent Sec probe is reported. Although this probe has been reported before for detection of biothiols, the studies in this work show that it can be used for rapid, high selective and sensitive detection of Sec over biothiols and many other analytes with dual colorimetric and fluorescent turn-on signal changes simply by slightly changing the detection conditions. The detection limit of this probe for Sec was found to be about 47 nM with a wide linear range (0–80 μM). In addition, this probe has low cytotoxicity and is able to detect Sec in serum samples and in living cells, indicating it can be used as a potential new molecular tool for Sec detection. © 2017 Elsevier Ltd
语种：
英文
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Highly selective near-infrared fluorescent probe with rapid response, remarkable large Stokes shift and bright fluorescence for H2S detection in living cells and animals
作者：
Hong, Jiaxin;Feng, Weiyong;Feng, Guoqiang*
期刊：
Sensors and Actuators B-Chemical ,2018年262:837-844 ISSN：0925-4005
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Hong, Jiaxin; Feng, Weiyong] Cent China Normal Univ, Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Hydrogen sulfide;Near-infrared fluorescent probe;Large stokes shift;In vitro and in vivo
摘要：
The detection of hydrogen sulfide (H2S) in living systems has received considerable attention in recent years. Although many probes have been reported for detection of cellular H2S, the creation of rapid, highly selective and sensitive near-infrared (NIR) probe for in vivo detection of H2S still remains a challenging target. Herein, a novel dicyanoisophorone-based NIR fluorescent turn-on probe for H2S was reported. This probe uses a sulfonamide group for the first time as a selective reaction site for H2S and more importantly, it displays a rapid (<1 min), highly selective and sensitive (detection limit: 6 nM) response for H2S, giving bright NIR fluorescence output (fluorescence enhancement >130-fold) with a remarkable large Stokes shift (221 nm). Moreover, it has low cytotoxicity and can be used for tracking and imaging of H2S in living cells and animals. Overall, this work provided a very promising NIR fluorescent probe with a new reaction site and excellent sensing properties for rapid detection of H2S both in vitro and in vivo. (C) 2018 Elsevier B.V. All rights reserved.
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英文
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A dicyanoisophorone-based near-infrared fluorescent probe and its application for detecting thiophenols in water and living cells
作者：
Hong, Jiaxin;Xia, Qingfeng;Feng, Weiyong;Feng, Guoqiang*
期刊：
Dyes and Pigments ,2018年159:604-609 ISSN：0143-7208
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Hong, Jiaxin; Feng, Weiyong; Xia, Qingfeng] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Dicyanoisophorone;Large Stokes shift;Living cells;NIR fluorescent probe;Thiophenols
摘要：
We report herein a new dicyanoisophorone-based colorimetric and near-infrared (NIR) fluorescent probe for rapid detection of thiophenols. This probe possesses a remarkable large Stokes shift (208 nm) and works in almost pure aqueous solution under mild conditions. More importantly, it displays a rapid, highly selective and sensitive dual colorimetric and NIR fluorescent turn-on signal responses for thiophenols and allows the detection of thiophenols in the presence of analytes including amino acids, biothiols and aliphatic thiols. Moreover, the fluorescence of this probe at 655 nm displays a good linear relationship with the thiophenol concentration ranging from 0 to 20 μM, and the detection limit is as low as 12 nM. Furthermore, the practicability of this new probe has been successfully proved by detection of thiophenol in real water samples and bioimaging of thiophenol in living cells. © 2018 Elsevier Ltd
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英文
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A simple but effective colorimetric and far-red to near-infrared fluorescent probe for palladium and its application in living cells
作者：
Kuhana, Tunga A.;Feng, Weiyong;Feng, Guoqiang*
期刊：
Dyes and Pigments ,2018年152:112-117 ISSN：0143-7208
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Kuhana, Tunga A.; Feng, Weiyong] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Hubei, Peoples R China.
关键词：
Bioimaging;Colorimetric;Fluorescent probe;Palladium;Seminaphthorhodafluor
摘要：
In this work, a new colorimetric and far-red to near-infrared fluorescent turn-on probe for rapid detection of palladium was reported. This probe uses a readily available seminaphthorhodafluor dye as the fluorophore and an allylcarbonate moiety as the reaction site. Based on the Pd0-triggered cleavage reaction, this probe shows rapid (within 2 min), selective, and sensitive response for palladium with different oxidation states (Pd0, or Pd2+ and Pd4+ in the presence of PPh3) in almost wholly aqueous solution under mild conditions, accompanied by distinct color changes and significant fluorescent turn-on signal in the far-red to near-infrared region. The detection limit of this probe for Pd0 was determined to be as low as 1.6 nM in solution. In addition, a sensitive bioimaging of palladiun in living cells can be achieved with a low level of this probe (2 μM), indicating the new developed probe has great potential for palladium detection in both solution and living systems. © 2018 Elsevier Ltd
语种：
英文
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A novel phthalimide-rhodol-based ESIPT-FRET system for rapid colorimetric and ratiometric fluorescent detection of palladium
作者：
Feng, Weiyong;Bai, Luoyi;Jia, Shuwen;Feng, Guoqiang*
期刊：
Sensors and Actuators B-Chemical ,2018年260:554-562 ISSN：0925-4005
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Jia, Shuwen; Bai, Luoyi; Feng, Weiyong] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Hubei Int Sci & Technol Cooperat Base Pesticide &, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Hubei Int Sci & Technol Cooperat Base Pesticide &, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Palladium;Colorimetric;Ratiometric fluorescent probe;Phthalimide-rhodol dyad;Esipt-fret;Living cells
摘要：
In this paper, a new colorimetric and ratiometric fluorescent probe was developed for rapid detection of palladium in aqueous solution under mild conditions. This probe is based on a novel phthalimiderhodol dyad, which has a unique ESIPT-FRET mechanism to give the desired ratiometric fluorescent signal changes. Optical sensing studies showed that this probe not only has high selectivity and sensitivity for palladium with a low detection limit of 31 nM, but also exhibits rapid and distinct colorimetric and ratiometric fluorescent signal changes with a large pseudo Stokes shift. In addition, the probe was successfully used for fluorescent imaging of palladium in living cells. Overall, this work provided a new ESIPT-FRET platform for development of ratiometric probes and a new attractive colorimetric and ratiometric fluorescent probe for detection of palladium. (C) 2017 Elsevier B.V. All rights reserved.
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英文
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A highly selective and sensitive colorimetric and near-infrared fluorescent turn-on probe for rapid detection of palladium in drugs and living cells
作者：
Xia, Qingfeng;Feng, Shumin;Liu, Dandan;Feng, Guoqiang*
期刊：
Sensors and Actuators B-Chemical ,2018年258:98-104 ISSN：0925-4005
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Liu, Dandan; Xia, Qingfeng; Feng, Shumin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Palladium;Colorimetric;NIR fluorescent probe;Drug;Living cell
摘要：
Palladium contamination has attracted widespread attention due to the toxicity and the wide use of palladium species. Consequently, development of convenient and effective methods for palladium detection is of great importance. Herein, a new colorimetric and near-infrared (NIR) fluorescent turn-on probe based on the Tsuji-Trost reaction for palladium was developed. This probe can be used to detect palladium in aqueous solution (for example, in pH 7.4 PBS buffer with 0–20% DMSO) under mild conditions with high selectivity and sensitivity, giving rapid (within 2 min) and distinct dual colorimetric and NIR fluorescent turn-on signal changes with a detection limit as low as 2.2 nM. A paper test strip system was prepared with this probe for a convenient visual detection of palladium. In addition, MTT assays showed that this probe has low cytotoxicity and detection of palladium in real drug samples and living cells was successfully applied with this probe, indicating this probe has a good application prospect.
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英文
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A smart near-infrared Fluorescent Probe for Selective and Sensitive Detection of Palladium
作者：
TUNGA KUHANA.A;Guoqiang Feng
作者机构：
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education,College of Chemistry,Central China Normal University
会议名称：
第十届全国化学生物学学术会议
会议时间：
2017-09-23
会议地点：
中国湖北武汉
会议论文集名称：
第十届全国化学生物学学术会议论文摘要集（墙报）
关键词：
palladium;near-infrared;excellent selectivity;living cells
摘要：
The using of heavy and transition metals, in particular palladium, in pharmacy such as catalytic converters, fuel cells, jewelry, dental crowns and so on, which led to high level of residual palladium in the final product, thus resulting in fearful environmental and health problems because it can bind to biomolecules like proteins, DNA, thiol-containing amino acids and disturb cellular processes. Therefore, we have synthesized the smart near-infrared fluorescent probe that can be used in different condition with rapid detection of palladium, excellent selectivity and sensitivity. This probe can be used also for fluorescent imaging Pd0 in living cells.
语种：
中文
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Selenocysteine detection and bioimaging in living cells by a colorimetric and near-infrared fluorescent turn-on probe with a large stokes shift
作者：
Li, Meixing;Feng, Weiyong;Zhai, Qisong;Feng, Guoqiang*
期刊：
Biosensors and Bioelectronics ,2017年87:894-900 ISSN：0956-5663
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Zhai, Qisong; Feng, Weiyong; Li, Meixing] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词：
Large Stokes shift;Living cells;Near-infrared fluorescent probe;Selenocysteine
摘要：
Selenocysteine (Sec) has emerged as an important sensing target in recent years. In this paper, a colorimetric and near-infrared fluorescent turn-on probe for Sec was developed. This probe features a remarkable large Stokes shift (146nm) and shows a rapid, highly selective detection process for Sec with obvious colorimetric and near-infrared fluorescent (Em 706nm with Ex 560nm) turn-on responses. In addition, this probe can be used to quantitatively detect Sec with high sensitivity with a detection limit of 62nM over a wide linear range (0.2–80μM). Moreover, it was further demonstrated that this NIR fluorescent probe can be employed to image both exogenous and endogenous Sec in living cells, indicating that this probe has great potential for biological applications. © 2016 Elsevier B.V.
语种：
英文
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Lighting up carbon monoxide in living cells by a readily available and highly sensitive colorimetric and fluorescent probe
作者：
Feng, Weiyong;Liu, Dandan;Zhai, Qisong;Feng, Guoqiang*
期刊：
Sensors and Actuators B-Chemical ,2017年240:625-630 ISSN：0925-4005
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Zhai, Qisong; Feng, Weiyong; Liu, Dandan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词：
Carbon monoxide;Fluorescent probe;Living cells;Tsuji–Trost reaction
摘要：
Carbon monoxide (CO) is an important gasotransmitter in living systems. The biological detection of this gasotransmitter is still in its infancy and urgently needs probes. In this paper, a novel fluorescent probe system, which is based on the Pd<sup>0</sup>-mediated Tsuji–Trost reaction, is reported for rapid detection of CO both in in vitro and in living cells. This probe system is readily available and shows excellent sensing properties for CO including rapid and distinct colorimetric and fluorescent turn-on responses, high selectivity and sensitivity with a low detection limit (25 nM) in aqueous solution under mild conditions. In addition, fluorescent imaging of CO in living cells can be conveniently achieved by a low dose of this probe system. ©2016 Elsevier B.V.
语种：
英文
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Colorimetric and ratiometric fluorescent detection of carbon monoxide in air, aqueous solution, and living cells by a naphthalimide-based probe
作者：
Feng, Weiyong;Hong, Jiaxin;Feng, Guoqiang*
期刊：
Sensors and Actuators B-Chemical ,2017年251:389-395 ISSN：0925-4005
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Hong, Jiaxin; Feng, Weiyong] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
关键词：
Carbon monoxide;Colorimetric;Ratiometric fluorescent probe;Living cells
摘要：
Carbon monoxide (CO), a highly toxic gas, is now well known as an important gasotransmitter in living systems. Accordingly, development of fluorescent probes for CO is of great significance. However, fluorescent detection of CO in living systems is challenging due to the lack of effective probes, and particularly, ratiometric fluorescent probes for CO have not yet been reported. In this article, a readily available colorimetric and ratiometric fluorescent probe system for CO was reported. This probe system shows excellent sensing properties for CO including rapid response, high selectivity and sensitivity with a low detection limit (58 nM), and capable of giving distinct colorimetric and ratiometric fluorescent signal changes for CO in aqueous solution under mild conditions. In addition, this probe system has low cytotoxicity and can be used to ratiometrically detect CO in living cells. Furthermore, a very convenient paper test strip system can be developed with this probe for visual detection of CO gas. Overall, this work provided a very promising probe for colorimetric and ratiometric fluorescent detection of CO in air, aqueous solution, and living cells. (C) 2017 Elsevier B.V. All rights reserved.
语种：
英文
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Allyl Fluorescein Ethers as Promising Fluorescent Probes for Carbon Monoxide Imaging in Living Cells
作者：
Feng, Shumin;Liu, Dandan;Feng, Weiyong;Feng, Guoqiang*
期刊：
Analytical Chemistry ,2017年89(6):3754-3760 ISSN：0003-2700
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Feng, Weiyong; Liu, Dandan; Feng, Shumin] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
Recently, the fluorescent detection of carbon monoxide (CO) in living cells has attracted great attention. However, due to the lack of effective ways to construct fluorescent CO probes, fluorescent detection of CO in living cells is still in its infancy. In this paper, we report for the first time the use of allyl ether as a reaction site for construction of fluorescent CO probes. By this way, two readily available allyl fluorescein ethers were prepared, which were found to be highly selective and sensitive probes for CO in the presence of PdCl2. These probes have the merits of good stability, good water-solubility, and rapid and distinct colorimetric and remarkable fluorescent turn-on signal changes. Moreover, a very low dose of these two probes can be used to detect and track CO in living cells, indicating that these two probes could be very promising biological tools for CO detection in living systems. Overall, this work provided not only two new promising fluorescent CO probes but also a new way to devise fluorescent CO probes. (Chemical Equation Presented). © 2017 American Chemical Society.
语种：
英文
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