作者机构：
[Zhou, Cheng; Liu, Ying; Yang, Shuaikang; Zang, Jianfeng; Liu, Xurui; Tian, Ye; Tang, Hanchuan] Huazhong Univ Sci & Technol, Sch Integrated Circuits, Wuhan 430074, Peoples R China.;[Zhou, Cheng; Liu, Ying; Kang, Tianyu; Yang, Shuaikang; Zang, Jianfeng; Liu, Xurui; Tian, Ye; Tang, Hanchuan] Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China.;[Chen, Wei; Zhang, Shujie] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China.;[Chen, Qicai] Cent China Normal Univ, Sch Life Sci, Wuhan 430074, Peoples R China.;[Xiao, Hongjun] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Otorhinolaryngol, Wuhan 430022, Peoples R China.
通讯机构：
[Hongjun Xiao; Hongjun Xiao Hongjun Xiao Hongjun Xiao] D;[Wei Chen; Wei Chen Wei Chen Wei Chen] C;[Jianfeng Zang; Jianfeng Zang Jianfeng Zang Jianfeng Zang] S;College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074 China<&wdkj&>School of Integrated Circuits and Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 China<&wdkj&>The State Key Laboratory of Digital Manufacturing Equipment and Technology, Huazhong University of Science and Technology, Wuhan, 430074 China<&wdkj&>Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China
摘要：
A bioinspired soft elastic metamaterial with a size equivalent to the current cochlear implant that can be seen as a prototype of passive artificial cochlea with a frequency resolution of 30 Hz is proposed. This work will inspire future work in the fabrication of totally implantable passive artificial cochlea that enables the users to hear naturally. Abstract Natural hearing which means hearing naturally like normal people is critical for patients with hearing loss to participate in life. Cochlear implants have enabled numerous severe hearing loss patients to hear voice functionally, while cochlear implant users can hardly distinguish different tones or appreciate music subject to the absence of rate coding and insufficient frequency channels. Here a bioinspired soft elastic metamaterial that reproduces the shape and key functions of the human cochlea is reported. Inspired by human cochlea, the metamaterials are designed to possess graded microstructures with high effective refractive index distributed on a spiral shape to implement position‐related frequency demultiplexing, passive sound enhancements of 10 times, and high‐speed parallel processing of 168‐channel sound/piezoelectric signals. Besides, it is demonstrated that natural hearing artificial cochlea has fine frequency resolution up to 30 Hz, a wide audible range from 150–12 000 Hz, and a considerable output voltage that can activate the auditory pathway in mice. This work blazes a promising trail for reconstruction of natural hearing in patients with severe hearing loss.
作者机构：
[Fu, Ziying; Wu, Jing; Cui, Zhongdan; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Fu, Ziying; Wu, Jing; Cui, Zhongdan; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;[Liu, Long] Natl Univ Def Technol, Coll Sci, Changsha 410073, Peoples R China.
通讯机构：
[Fu, Ziying] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
Although acoustic communication is inevitably influenced by noise, behaviorally relevant sounds are perceived reliably. The noise-tolerant and -invariant responses of auditory neurons are thought to be the underlying mechanism. So, it is reasonable to speculate that neurons with best frequency tuned to behaviorally relevant sounds will play important role in noise-tolerant perception. Echolocating bats live in groups and emit multiple harmonic signals and analyze the returning echoes to extract information about the target features, making them prone to deal with noise in their natural habitat. The echolocation signal of Hipposideros pratti usually contains 3-4 harmonics (H-1-H-4), the second harmonic has the highest amplitude and is thought to play an essential role during echolocation behavior. Therefore, it is reasonable to propose that neurons tuned to the H-2, named the H-2 neurons, can be more noise-tolerant to background noise. Taking advantage of bat's stereotypical echolocation signal and single-cell recording, our present study showed that the minimal threshold increases (12.2 dB) of H-2 neurons in the auditory midbrain were comparable to increase in bat's call intensity (14.2 dB) observed in 70 dB SPL white noise condition, indicating that the H-2 neurons could work as background noise monitor. The H-2 neurons had higher minimal thresholds and sharper frequency tuning, which enabled them to be more tolerant to background noise. Furthermore, the H-2 neurons had consistent best amplitude spikes and sharper intensity tuning in background white noise condition than in silence. Taken together, these results suggest that the H-2 neurons might account for noise-tolerant perception of behaviorally relevant sounds. (C) 2020 Elsevier B.V. All rights reserved.
作者机构：
[Zha, Yu-Ping; Zhang, Zi-Yi; Chen, Jing-Yuan] Hubei Acad Forestry, Wuhan 430075, Peoples R China.;[Chen, Qi-Cai; Wu, Xiao-Ling] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.;[Chen, Qi-Cai; Wu, Xiao-Ling] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Zha, Yu-Ping] H;Hubei Academy of Forestry, Wuhan, People’s Republic of China
摘要：
<jats:title>Abstract</jats:title><jats:p>Abiotic stress factors can significantly affect insects. In particular, the stressful effects of exposure to ultrasound on insects are considered important. In the present study, we investigated the effects of ultrasound on the important global pest <jats:italic>Monochamus alternatus</jats:italic> (Coleoptera: Cerambycidae), which is the main vector of the pinewood nematode. We exposed <jats:italic>M. alternatu</jats:italic>s adults (aged 1day, 3days, and 5days) to ultrasound at different frequencies (using two ultrasonic devices, i.e., LHC20 with a mixture of frequencies at 35kHz, 70kHz, and 105kHz; and GFG-8016G at two separate frequencies of 30kHz and 60kHz) for different periods of time (1h, 12h, and 24h), before evaluating the juvenile hormone III (JHIII) titers. All of the ultrasound treatments significantly decreased the JHIII titers in <jats:italic>M. alternatus</jats:italic> adults. The decreases in the JHIII titers due to ultrasound exposure did not differ according to sex, but the effects on beetles of different ages differed significantly depending on the duration of exposure. The decreases in the JHIII titers were highest in male and female beetles after exposure to ultrasound for 12h. Following exposure to ultrasound for any time period, the decreases in the JHIII titers were lower in adults aged 3days than those aged 1day and 5days. The different ultrasonic frequencies led to variable decreases in the JHIII titers in <jats:italic>M. alternatus</jats:italic> adults, where the greatest decreases occurred in beetles exposed to ultrasound at 60kHz. Our results indicate that ultrasound can negatively affect the normal JHIII levels and it may further disrupt sexual maturation by <jats:italic>M. alternatus</jats:italic> adults.</jats:p>
作者：
Yang, Yin*;Chen, Qi Cai;Shen, Jun Xian;Jen, Philip H-S*
期刊：
Neuroscience,2020年424:72-85 ISSN：0306-4522
通讯作者：
Yang, Yin;Jen, Philip H-S
作者机构：
[Yang, Yin] Binzhou Med Univ, Coll Special Educ, Yantai, Shandong, Peoples R China.;[Chen, Qi Cai] Cent China Normal Univ, Coll Life Sci, Wuhan, Hubei, Peoples R China.;[Shen, Jun Xian] Chinese Acad Sci, Inst Biophys, Beijing, Peoples R China.;[Jen, Philip H-S] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
通讯机构：
[Yang, Yin] B;[Jen, Philip H-S] U;Binzhou Med Univ, Coll Special Educ, Yantai, Shandong, Peoples R China.;Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
关键词：
bat;binaurality and frequency representation;interaural level difference (ILD);primary auditory cortex;tonotopic organization
摘要：
This study examines binaural response properties and sensitivity to interaural level difference of single neurons in the primary auditory cortex (AC) of the big brown bat, Eptesicus fuscus under earphone stimulation conditions. Contralateral sound stimulation always evoked response from all 306 AC neurons recorded but ipsilateral sound stimulation either excited, inhibited or did not affect their responses. High best frequency (BF) neurons typically had high minimum threshold (MT) and low BF neurons had low MT. However, both BF and MT did not correlate with their recording depth. The BF of these AC neurons progressively changed from high to low along the anteromedial-posterolateral axis of the AC. Their number of impulses and response latency varied with sound level and inter-aural level differences (ILD). Their number of impulses typically increased either monotonically or non-monotonically to a maximum and the latency shortened to a minimum at a specific sound level. Among 205 AC neurons studied at varied ILD, 178 (87%) and 127 (62%) neurons discharged maximally and responded with the shortest response latency at a specific ILD, respectively. Neurons sequentially isolated within an orthogonal electrode puncture shared similar BF, MT, binaurality and ILD curves. However, the response latency of these AC neurons progressively shortened with recording depth. Species-specific difference among this bat, the mustached bat and the pallid bat is discussed in terms of frequency and binaurality representation in the AC.
作者机构：
[Chen, Qi-Cai; Wang, Xin; Yang, Dan-Dan; Cheng, Yan-Ling; Si, Wen-Juan] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;[Jen, Philip H. -S.] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.;[Yang, Cui-Hong] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Chen, Qi-Cai] C;[Jen, Philip H. -S.] U;Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
关键词：
Bicuculline;DNLL;Dorsal nucleus of the lateral lemniscus;GABAergic input;Inferior colliculus;Mice;Temporal signal processing
摘要：
The inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within IC, contralateral IC through the commissure of IC and from the auditory cortex (AC). These excitatory and inhibitory inputs from both ascending and descending auditory pathways contribute significantly to auditory response properties and temporal signal processing in IC. The present study examines the contribution of gamma-aminobutyric acid-ergic (GABAergic) inhibition of dorsal nucleus of the lateral lemniscus (DNLL) in influencing the response properties and amplitude sensitivity of contralateral IC neurons using focal electrical stimulation of contralateral DNLL and by the application of bicuculline to the recording site of modulated IC neurons. Focal electrical stimulation of contralateral DNLL produces inhibition (78.1%), facilitation (7.1%) or no effect (14.8%) in the number of spikes, firing duration and the first-spike latency of modulated IC neurons. The degree of modulation is inversely correlated to the difference in best frequency (BF) between electrically stimulated DNLL neurons and modulated IC neurons (p<0.01). The application of bicuculline to the recording site of modulated IC neurons abolishes the inhibitory effect of focal electrical stimulation of DNLL neurons. DNLL inhibition also modulates the amplitude sensitivity of IC neurons by changing the dynamic range (DR) and the slope of rate-amplitude function (RAF) of modulated IC neurons. Possible biological significance of these findings in relation to auditory signal processing is discussed.
作者机构：
[Fu, Ziying; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia; Shi, Qing] Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.;[Fu, Ziying; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia; Shi, Qing] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.;[Liu, Long] Natl Univ Def Technol, Coll Sci, Changsha, Hunan, Peoples R China.
通讯机构：
[Chen, Qicai] C;Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.
关键词：
Neurons;Bats;Neuronal tuning;Echolocation;Animal behavior;Behavior;Action potentials;Auditory system
摘要：
Frequency analysis is a fundamental function of the auditory system, and it is essential to study the auditory response properties using behavior-related sounds. Our previous study has shown that the inferior collicular (IC) neurons of CF-FM (constant frequency-frequency modulation) bats could be classified into single-on (SO) and double-on (DO) neurons under CF-FM stimulation. Here, we employed Pratt's roundleaf bats, Hipposideros pratti, to investigate the frequency selectivity of SO and DO neurons in response to CF and behavior-related CF-FM sounds using in vivo extracellular recordings. The results demonstrated that the bandwidths (BWs) of iso-frequency tuning curves had no significant differences between the SO and the DO neurons when stimulated by CF sounds. However, the SO neurons had significant narrower BWs than DO neurons when stimulated with CF-FM sounds. In vivo intracellular recordings showed that both SO and DO neurons had significantly shorter post-spike hyperpolarization latency and excitatory duration in response to CF-FM in comparison to CF stimuli, suggesting that the FM component had an inhibitory effect on the responses to the CF component. These results suggested that SO neurons had higher frequency selectivity than DO neurons under behavior-related CF-FM stimulation, making them suitable for detecting frequency changes during echolocation.
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY,2019年205(2):239-252 ISSN：0340-7594
通讯作者：
Chen, Qicai;Jen, Philip Hung-Sun
作者机构：
[Fu, Ziying; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia; Xu, Na] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Fu, Ziying; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia; Xu, Na] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;[Liu, Long] Natl Univ Def Technol, Coll Sci, Changsha 410073, Hunan, Peoples R China.;[Jen, Philip Hung-Sun] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.;[Xu, Na] Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, Beijing 100080, Peoples R China.
通讯机构：
[Chen, Qicai] C;[Jen, Philip Hung-Sun] U;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
关键词：
Auditory signal processing;CF-FM bat;Evoked potential;FM bat;Inferior colliculus
摘要：
The auditory system of echolocating bats is adapted for processing species-specific ultrasonic signals. While FM (frequency modulation) bats are strictly sensitive to the frequency ranges of their orientation signals or prey-generated noise, CF-FM (constant frequency-FM) bats have a disproportionate number of neurons tuned to frequencies near the CF component of their orientation sounds, and most of them are on-off responders. Furthermore, the inferior collicular neurons of the CF-FM bats discharged as single-on or double-on responders to CF-FM stimuli. To further study the differences in auditory signal processing of these two types of bats, as the first step we conducted an evoked potential response study in the inferior colliculus of the CF-FM bat, Hipposideros pratti and the FM bat, Pipistrellus abramus using CF, FM and CF-FM stimuli. The results showed that the CF sounds always evoked collicular on- and off-responses in CF-FM bats, but the FM bats only had on-responses to both CF and FM sounds, indicting species-specific neural circuits. However, when stimulated with CF-FM sounds, collicular responses were evoked by both the CF and FM components from both FM and CF-FM bats, suggesting they have some generic neural circuit.
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY,2018年204(7):653-665 ISSN：0340-7594
通讯作者：
Chen, Qi-Cai
作者机构：
[Fu, Zi-Ying; Chen, Qi-Cai; Peng, Kang; Wang, Xin; Tang, Jia; Yang, Ming-Jian; Wang, Jing] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Fu, Zi-Ying; Chen, Qi-Cai; Peng, Kang; Wang, Xin; Tang, Jia; Yang, Ming-Jian; Wang, Jing] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;[Yang, Ming-Jian] Handan Univ, Sch Life Sci & Engn, Handan 056005, Peoples R China.
通讯机构：
[Chen, Qi-Cai] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
During hunting, the duration and amplitude of bat’s echolocation sounds co-vary. Our previous studies showed the inferior collicular neurons of constant frequency-frequency modulation (CF-FM) bat discharged as single-on (SO) or double-on (DO) responders when stimulated with behavior related CF-FM sounds. However, how the co-varied sound duration and amplitude modulate the response properties of SO and DO neurons were understudied. Therefore, we investigated amplitude- and duration-sensitivity in 121 neurons isolated in the inferior colliculus of CF-FM bat, Pratt’s roundleaf bat (Hipposideros pratti). Responses of SO and DO neurons were obtained by in vivo intracellular recordings and examined for different stimulus amplitudes and durations. Our results revealed that response patterns of SO neurons were unaffected by changes in amplitude and duration of CF-FM stimuli. However, the excitability of DO neurons increased with prolonged CF duration and higher amplitude of CF-FM stimuli. These data suggested that the invariance of SO neurons play a key role in detection of Doppler shift and glint-like changes of frequency and amplitude induced by wingbeats of insects. In contrast, amplitude- and duration-sensitivity of DO neurons to CF-FM stimuli is consistent with the systematic changes in these signal parameters during sequential phases of foraging in CF-FM bats.
作者：
Wang Qiao-Chao;Kong Hui-Fang;Cheng Ya-Wen;Wang Hui-Mei;Fu Zi-Ying（付子英）;...
期刊：
生物化学与生物物理进展,2018年45(7):723-735 ISSN：1000-3282
通讯作者：
Tang Jia
作者机构：
[Tang Jia] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Tang Jia] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.
作者机构：
[Chen, Qi-Cai] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Chen, Qi-Cai] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.
关键词：
Recovery cycle;Inter-pulse interval;Doppler-shift compensation;Inferior collicular neuron;CF-FM bat
摘要：
The Doppler-shift compensation (DSC) behavior of constant frequency - frequency modulation (CF-FM) bat (Hipposideros pratti) is vital for extraction and analysis of echo information. This type of behavior affects the recovery cycles of sound-sensitive neurons, but their precise relationship remains unclear. In this study, we investigated the effects of DSC on the recovery cycles of inferior collicular (IC) neurons in H. pratti. We simulated the pulse-echo pair in bats by changing the emitted pulse frequency and keeping the echo frequency constant during DSC in echolocation. The neuronal recovery cycles of IC neurons are categorized into four types: unrecovered, monotonic, single-peak, and multi-peak. The recovery cycle of IC neurons shortens after DSC; moreover, the amount of neurons with multi-peak recovery cycle increases and concentrates in the short recovery area. This paper also discusses the possible neural mechanisms and their biological relevance to different phases of bat predation behavior. (C) 2017 Elsevier Inc. All rights reserved.
作者机构：
[Chen, Qi-Cai] Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Peoples R China.
通讯机构：
[Chen, Qi-Cai] C;Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.
摘要：
In the auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from the lower auditory nuclei, contralateral IC, and auditory cortex (AC), and then uploads these inputs to the thalamus and cortex. Meanwhile, the AC modulates the sound signal processing of IC neurons, including their latency (i.e., first-spike latency). Excitatory and inhibitory corticofugal projections to the IC may shorten and prolong the latency of IC neurons, respectively. However, the synaptic mechanisms underlying the corticofugal latency modulation of IC neurons remain unclear. Thus, this study probed these mechanisms via in vivo intracellular recording and acoustic and focal electric stimulation. The AC latency modulation of IC neurons is possibly mediated by pre-spike depolarization duration, pre-spike hyperpolarization duration, and spike onset time. This study suggests an effective strategy for the timing sequence determination of auditory information uploaded to the thalamus and cortex.
摘要：
Currently, there is limited information about the relationship between manganese superoxide dismutase (sod2) c47t polymorphism and susceptibility to noise-induced hearing loss (NIHL).
The aim of this meta-analysis was to clarify the association between SOD2 C47T polymorphism and NIHL.
A search in PubMed and Web of Science was performed to collect data. All full-text, English-written studies containing sufficient and complete case-and-control data about the relationship between SOD2 C47T polymorphism and NIHL were included. Three eligible studies, comprising 1094 subjects, were identified. pooled odds ratios (ORs) and 95% confidence intervals (CI) were calculated to evaluate the strength of the association between SOD2 C47T polymorphism and NIHL.
No significant association between C47T polymorphism and risk of NIHL was found with the following combinations: T vs. C (OR = 0.83; 95% CI = 0.63–1.09); TT vs. CC (OR = 0.49; 95% CI = 0.22–1.09); CT vs. CC (OR = 0.54; 95% CI = 0.25–1.17); TT vs. CC + CT (OR = 0.82; 95% CI = 0.50–1.32); CC vs. TT + TC (OR = 0.49; 95% CI = 0.23–1.04). However, in subgroup analysis, a significant association was found for TT vs. CC + CT (OR = 0.77; 95% CI = 0.42–1.41) in the Chinese population.
The present meta-analysis suggests that SOD2 C47T polymorphism is significantly associated with increased risk of NIHL in the Chinese population. Further large and well-designed studies are needed to confirm this association.
Atualmente, são limitadas as informações acerca da relação entre o polimorfismo C47T de superóxido dismutase 2 (SOD2) dependente de manganês e suscetibilidade à perda auditiva induzida pelo ruído (PAIR).
O objetivo desta metanálise foi esclarecer a associação entre o polimorfismo C47T de SOD2 e PAIR.
Foi realizadas buscas no PubMed e Web of Science para coleta de dados. Foram incluídos todos os estudos no idioma inglês, contendo dados suficientes e completos de casos e controles sobre a relação entre o polimorfismo C47T de SOD2 e PAIR. Foram identificados três estudos qualificados, abrangendo 1.094 indivíduos. Foram calculadas as razões das chances (odds ratio, OR) acumuladas e intervalos de confiança (IC) de 95% para que fosse avaliada a potência da associação entre o polimorfismo C47T de SOD2 e PAIR.
Não foi encontrada uma associação significativa entre o polimorfismo C47T de SOD2 e risco de PAIR com as seguintes combinações: T vs. C (OR = 0,83, IC 95% = 0,63-1,09); TT vs. CC (OR = 0,49, IC 95% = 0,22-1,09); CT vs. CC (OR = 0,54, IC 95% = 0,25-1,17); TT vs. CC + CT (OR = 0,82, IC 95% = 0,50-1,32); CC vs. TT + TC (OR = 0,49, IC 95% = 0,23-1,04). Contudo, na análise de subgrupo, foi encontrada uma associação significativa para TT vs. CC + CT (OR = 0,77, 95% CI = 0,42-1.41) na população chinesa.
A presente metanálise sugere que o polimorfismo C47T de SOD2 demonstra associação significativa com maior risco de PAIR na população chinesa. Há necessidade de novos estudos de grande porte bem concebidos, para confirmação dessa associação.
摘要：
目的先前的研究发现,在行为相关的CF-FM声刺激下,CF-FM蝙蝠的下丘(inferior colliculus,IC)神经元显示出要么产生单反应(single-on,SO),要么产生双反应(double-on,DO)(Fu et al.,2010;Tang et al.,2011;Li et al.,2015)。两类神经元对行为相关声信号的频率选择性是否不同?尚需研究。方法 10只普氏蹄蝠(Hi
