作者：
Cheng, L.;Mei, H. -X.;Tang, J.;Fu, Z-Y（付子英）;Jen, P. H. -S.*;...
期刊：
Neuroscience,2013年235(1):27-39 ISSN：0306-4522
通讯作者：
Jen, P. H. -S.
作者机构：
[Fu, Z-Y; Cheng, L.; Chen, Q. -C.; Mei, H. -X.; Tang, J.] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.;[Fu, Z-Y; Cheng, L.; Chen, Q. -C.; Mei, H. -X.; Tang, J.] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.;[Jen, P. H. -S.] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
通讯机构：
[Jen, P. H. -S.] U;Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
摘要：
In the ascending auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from a variety of lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and the auditory cortex. All these connections make the IC a major center for subcortical temporal and spectral integration of auditory information. In this study, we examine bilateral collicular interaction in the modulation of frequencydomain signal processing of mice using electrophysiological recording and focal electrical stimulation. Focal electrical stimulation of neurons in one IC produces widespread inhibition and focused facilitation of responses of neurons in the other IC. This bilateral collicular interaction decreases the response magnitude and lengthens the response latency of inhibited IC neurons but produces an opposite effect on the response of facilitated IC neurons. In the frequency domain, the focal electrical stimulation of one IC sharpens or expands the frequency tuning curves (FTCs) of neurons in the other IC to improve frequency sensitivity and the frequency response range. The focal electrical stimulation also produces a shift in the best frequency (BF) of modulated IC (ICmdu) neurons toward that of electrically stimulated IC (ICES) neurons. The degree of bilateral collicular interaction is dependent upon the difference in the BF between the ICES neurons and ICmdu neurons. These data suggest that bilateral collicular interaction is a part of dynamic acoustic signal processing that adjusts and improves signal processing as well as reorganizes collicular representation of signal parameters according to the acoustic experience. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
作者机构：
[付子英; 李娟; 唐佳; 陈其才; Zeng H.] School of Life Sciences and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, 430079, China
作者机构：
[Fu, Zi-Ying; Chen, Qi-Cai; Tang, Jia; Mei, Hui-Xian; Cheng, Liang] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.;[Jen, Philip H-S] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.;[Fu, Zi-Ying; Chen, Qi-Cai; Tang, Jia; Mei, Hui-Xian; Cheng, Liang] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Jen, Philip H-S] U;Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
关键词：
Amplitude signal processing;Bilateral collicular interaction;Corresponding vs. non-corresponding frequency laminae;Suppressive vs. facilitatory modulation
摘要：
In the ascending auditory pathway, the commissure of the inferior colliculus (IC) interconnects the two ICs and may therefore mediate bilateral collicular interaction during sound processing. In this study, we show that electrically stimulates one IC produces facilitation or suppression of acoustically evoked response of neurons in the other IC. The facilitated IC neurons (14%) are located in bilateral corresponding frequency laminae while the suppressed IC neurons (86%) are widespreadly located in bilateral different frequency laminae. Whereas induced facilitation increases the dynamic range but decreases the slope of the rate-amplitude function of modulated IC neurons, induced suppression produces the opposite effect. As a result, bilateral collicular facilitation increases the sensitivity of modulated IC neurons to a wider range of sound amplitude while bilateral collicular suppression improves the sensitivity of modulated IC neurons to minor change in sound amplitude over a narrower range of sound amplitude. The degree of suppression is significantly greater for suppressed IC neurons located in bilateral corresponding frequency laminae than in non-corresponding frequency laminae. We suggest that bilateral collicular interaction through the commissure of the IC may play a role in modulation of amplitude sensitivity and in shaping the binaural property of IC neurons. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
摘要：
In the ascending auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these connections make the IC a major center for subcortical temporal and spectral integration of auditory information. In this study, we examine bilateral collicular interaction in modulating amplitude-domain signal processing using electrophysiological recording, acoustic and focal electrical stimulation. Focal electrical stimulation of one (ipsilateral) IC produces widespread inhibition (61.6%) and focused facilitation (9.1%) of responses of neurons in the other (contralateral) IC, while 29.3% of the neurons were not affected. Bilateral collicular interaction produces a decrease in the response magnitude and an increase in the response latency of inhibited IC neurons but produces opposite effects on the response of facilitated IC neurons. These two groups of neurons are not separately located and are tonotopically organized within the IC. The modulation effect is most effective at low sound level and is dependent upon the interval between the acoustic and electric stimuli. The focal electrical stimulation of the ipsilateral IC compresses or expands the rate-level functions of contralateral IC neurons. The focal electrical stimulation also produces a shift in the minimum threshold and dynamic range of contralateral IC neurons for as long as 150 minutes. The degree of bilateral collicular interaction is dependent upon the difference in the best frequency between the electrically stimulated IC neurons and modulated IC neurons. These data suggest that bilateral collicular interaction mainly changes the ratio between excitation and inhibition during signal processing so as to sharpen the amplitude sensitivity of IC neurons. Bilateral interaction may be also involved in acoustic-experience-dependent plasticity in the IC. Three possible neural pathways underlying the bilateral collicular interaction are discussed.
作者机构：
[Chen, Qi-Cai] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Chen, Qi-Cai] C;Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
关键词：
FM component;Rate-amplitude function;Sound amplitude sensitivity;Inferior collicular neurons
摘要：
Zi-Ying Fu, Jia Tang, Yang Li, Hong Zeng, and Qi-Cai Chen (2011) Frequency-modulation component of the mimic echolocation sound can increase the sensitivity of inferior collicular neurons to sound amplitude in the leaf-nosed bat, Hipposideros armiger. Zoological Studies 50(5): 537-545. A frequency modulation (FM) component widely exists in many bats' echolocation calls and human speech sounds. In order to investigate the role of the FM component in sound communication, 6 leaf-nosed bats, Hipposideros armiger, were used in this experiment. In total, 113 inferior collicular (IC) neurons were obtained, and the responses of 61 neurons among these neurons to constant frequency (CF) and mimic CF-FM sounds and their rate-amplitude functions (RAFs) were studied. According to the responses of the neurons to CF and CF-FM sounds at different amplitudes, RAFs of these neurons were classified into 3 types, monotonic, saturated, and non-monotonic. When CF sounds were changed into CF-FM sounds, the best amplitudes of the neurons decreased from 93.0 +/- 9.8 to 84.4 +/- 11.3 dB SPL (p < 0.01), and the dynamic ranges decreased from 27.5 +/- 9.4 to 22.5 +/- 8.5 dB (p < 0.05), but the slopes of the RAFs increased from 3.1 +/- 1.4 to 4.1 +/- 1.7%/dB (p < 0.05). By further analyzing the influence of the FM component on the firing rate of the neurons, it was shown that the FM component elevated the firing rate of the neurons at < 30 dB above the minimum threshold (MT), while reducing the firing rate at > 30 dB above the MT (p < 0.001). The results indicate that the FM component of CF-FM sound can increase the sensitivity of IC neurons to sound amplitude. http://zoolstud.sinica.edu.tw/Journals/50.5/537.pdf
作者机构：
[Chen Qi-Cai] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Chen Qi-Cai] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.
摘要：
先前的研究表明,神经元可通过其发放率、潜伏期及复杂的发放模式来传递感觉信息(Nelken et al.2005)。在猫、兔、豚鼠、大鼠多种动物的下丘所做的细胞外记录(Rees et al.1997),以及在体膜片钳和离体脑片记录(Bal et al.2002;Koch et al.2003;Peruzzi et al.2000;Tan et al.2007),均观察到神经元的不同发放模式,如何定型
摘要：
在过去的几十年中一直不断有人在对前掩蔽进行研究,获得了不少有意义的研究结果和新的认识(L(u|¨)scher and Zwislocki,1949;Turner,1994;Wang et al.,2007)。然而,对前掩蔽形成的机制一直存在争议。早期心理物理学以及后来的神经药理学和在体膜片钳记录研究,相继提出了适应(Elliott,1962;Penner,1975)、神经抑制(Frisina,20
作者：
Tang Jia;Fu Zi-Ying（付子英）;Jen, Philip H-S;Chen Qi-Cai*
期刊：
生物化学与生物物理进展,2010年37(7):801-808 ISSN：1000-3282
通讯作者：
Chen Qi-Cai
作者机构：
[Fu Zi-Ying; Chen Qi-Cai; Tang Jia] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.;[Fu Zi-Ying; Chen Qi-Cai; Tang Jia] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.;[Jen, Philip H-S] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.;[Jen, Philip H-S] Univ Missouri, Interdisciplinary Neurosci Program, Columbia, MO 65211 USA.
通讯机构：
[Chen Qi-Cai] C;Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
摘要：
蝙蝠在进行回声定位的过程中,为了准确定位目标,会随着不断地靠近目标而系统性的调节回声定位信号的参数(Simmons et al.,1979;Jen and Kamada,1982;Schnitzler,1968;Surlykke and Moss,1989),例如,降低频率,缩短发声时程、提高脉冲重复率(pulserepetition rate,PRR)等。因此,本实验特地研究声时程的改变对听中枢
作者：
Fu, Zi-Ying（付子英）;Tang, Jia;Jen, Philip Hung-Sun;Chen, Qi-Cai*
期刊：
Brain Research,2010年1306:39-52 ISSN：0006-8993
通讯作者：
Chen, Qi-Cai
作者机构：
[Fu, Zi-Ying; Chen, Qi-Cai; Tang, Jia] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.;[Fu, Zi-Ying; Chen, Qi-Cai; Tang, Jia] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.;[Jen, Philip Hung-Sun] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
通讯机构：
[Chen, Qi-Cai] C;Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
作者机构：
[付子英; 唐佳; 陈其才] 华中师范大学生命科学学院;[JEN Philip Hung-Sun] Division of Biological Sciences and Interdisciplinary Neuroscience Program, University of Missouri-Columbia
