作者机构：
[Fu, Ziying; Wu, Jing; Cui, Zhongdan; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Fu, Ziying; Wu, Jing; Cui, Zhongdan; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;[Liu, Long] Natl Univ Def Technol, Coll Sci, Changsha 410073, Peoples R China.
通讯机构：
[Fu, Ziying] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
Although acoustic communication is inevitably influenced by noise, behaviorally relevant sounds are perceived reliably. The noise-tolerant and -invariant responses of auditory neurons are thought to be the underlying mechanism. So, it is reasonable to speculate that neurons with best frequency tuned to behaviorally relevant sounds will play important role in noise-tolerant perception. Echolocating bats live in groups and emit multiple harmonic signals and analyze the returning echoes to extract information about the target features, making them prone to deal with noise in their natural habitat. The echolocation signal of Hipposideros pratti usually contains 3-4 harmonics (H-1-H-4), the second harmonic has the highest amplitude and is thought to play an essential role during echolocation behavior. Therefore, it is reasonable to propose that neurons tuned to the H-2, named the H-2 neurons, can be more noise-tolerant to background noise. Taking advantage of bat's stereotypical echolocation signal and single-cell recording, our present study showed that the minimal threshold increases (12.2 dB) of H-2 neurons in the auditory midbrain were comparable to increase in bat's call intensity (14.2 dB) observed in 70 dB SPL white noise condition, indicating that the H-2 neurons could work as background noise monitor. The H-2 neurons had higher minimal thresholds and sharper frequency tuning, which enabled them to be more tolerant to background noise. Furthermore, the H-2 neurons had consistent best amplitude spikes and sharper intensity tuning in background white noise condition than in silence. Taken together, these results suggest that the H-2 neurons might account for noise-tolerant perception of behaviorally relevant sounds. (C) 2020 Elsevier B.V. All rights reserved.
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY,2019年205(2):239-252 ISSN：0340-7594
通讯作者：
Chen, Qicai;Jen, Philip Hung-Sun
作者机构：
[Fu, Ziying; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia; Xu, Na] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Fu, Ziying; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia; Xu, Na] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;[Liu, Long] Natl Univ Def Technol, Coll Sci, Changsha 410073, Hunan, Peoples R China.;[Jen, Philip Hung-Sun] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.;[Xu, Na] Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, Beijing 100080, Peoples R China.
通讯机构：
[Chen, Qicai] C;[Jen, Philip Hung-Sun] U;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
关键词：
Auditory signal processing;CF-FM bat;Evoked potential;FM bat;Inferior colliculus
摘要：
The auditory system of echolocating bats is adapted for processing species-specific ultrasonic signals. While FM (frequency modulation) bats are strictly sensitive to the frequency ranges of their orientation signals or prey-generated noise, CF-FM (constant frequency-FM) bats have a disproportionate number of neurons tuned to frequencies near the CF component of their orientation sounds, and most of them are on-off responders. Furthermore, the inferior collicular neurons of the CF-FM bats discharged as single-on or double-on responders to CF-FM stimuli. To further study the differences in auditory signal processing of these two types of bats, as the first step we conducted an evoked potential response study in the inferior colliculus of the CF-FM bat, Hipposideros pratti and the FM bat, Pipistrellus abramus using CF, FM and CF-FM stimuli. The results showed that the CF sounds always evoked collicular on- and off-responses in CF-FM bats, but the FM bats only had on-responses to both CF and FM sounds, indicting species-specific neural circuits. However, when stimulated with CF-FM sounds, collicular responses were evoked by both the CF and FM components from both FM and CF-FM bats, suggesting they have some generic neural circuit.
作者机构：
[Fu, Ziying; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia; Shi, Qing] Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.;[Fu, Ziying; Zhou, Dandan; Chen, Qicai; Zhang, Guimin; Tang, Jia; Shi, Qing] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.;[Liu, Long] Natl Univ Def Technol, Coll Sci, Changsha, Hunan, Peoples R China.
通讯机构：
[Chen, Qicai] C;Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.
摘要：
Frequency analysis is a fundamental function of the auditory system, and it is essential to study the auditory response properties using behavior-related sounds. Our previous study has shown that the inferior collicular (IC) neurons of CF-FM (constant frequency-frequency modulation) bats could be classified into single-on (SO) and double-on (DO) neurons under CF-FM stimulation. Here, we employed Pratt's roundleaf bats, Hipposideros pratti, to investigate the frequency selectivity of SO and DO neurons in response to CF and behavior-related CF-FM sounds using in vivo extracellular recordings. The results demonstrated that the bandwidths (BWs) of iso-frequency tuning curves had no significant differences between the SO and the DO neurons when stimulated by CF sounds. However, the SO neurons had significant narrower BWs than DO neurons when stimulated with CF-FM sounds. In vivo intracellular recordings showed that both SO and DO neurons had significantly shorter post-spike hyperpolarization latency and excitatory duration in response to CF-FM in comparison to CF stimuli, suggesting that the FM component had an inhibitory effect on the responses to the CF component. These results suggested that SO neurons had higher frequency selectivity than DO neurons under behavior-related CF-FM stimulation, making them suitable for detecting frequency changes during echolocation.
摘要：
Many bees are effective pollen collectors; however, pollen grains collected by bees for larval food are lost for plant sexual reproduction. Recognition of these conflicting interests between bees and flowers is essential for understanding of reproduction for both bees and flowers [1-3]. Plant defense compounds in pollen may function to reduce pollen waste by deterring ineffective pollinators [4-6], but this hypothesis remains unexamined. Here, we provide evidence that secondary metabolites in pollen function as chemical defense by deterring some bees from gathering pollen. In two Dipsacus species, a defense compound, dipsacus saponin [7], occurs in pollen but not in nectar. We observed that bumblebees disliked grooming bitter-tasting pollen with a high saponin content. Manipulation of saponin concentrations in nectar and measurements of corbicular pollen showed that the bumblebee species differed in their tolerance to saponin. Those species susceptible to saponin groomed little Dipsacus pollen into their pollen loads, and their ungroomed pollen was observed to be effectively delivered to stigmas. By rewarding bees with edible nectar, but not pollen, plants solve the conflict of pollen partitioning between sexual and reward functions. Ungroomed toxic pollen on the bee body promotes pollen transfer efficiency, facilitating pollination.
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY,2018年204(7):653-665 ISSN：0340-7594
通讯作者：
Chen, Qi-Cai
作者机构：
[Fu, Zi-Ying; Chen, Qi-Cai; Peng, Kang; Wang, Xin; Tang, Jia; Yang, Ming-Jian; Wang, Jing] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Fu, Zi-Ying; Chen, Qi-Cai; Peng, Kang; Wang, Xin; Tang, Jia; Yang, Ming-Jian; Wang, Jing] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.;[Yang, Ming-Jian] Handan Univ, Sch Life Sci & Engn, Handan 056005, Peoples R China.
通讯机构：
[Chen, Qi-Cai] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
During hunting, the duration and amplitude of bat’s echolocation sounds co-vary. Our previous studies showed the inferior collicular neurons of constant frequency-frequency modulation (CF-FM) bat discharged as single-on (SO) or double-on (DO) responders when stimulated with behavior related CF-FM sounds. However, how the co-varied sound duration and amplitude modulate the response properties of SO and DO neurons were understudied. Therefore, we investigated amplitude- and duration-sensitivity in 121 neurons isolated in the inferior colliculus of CF-FM bat, Pratt’s roundleaf bat (Hipposideros pratti). Responses of SO and DO neurons were obtained by in vivo intracellular recordings and examined for different stimulus amplitudes and durations. Our results revealed that response patterns of SO neurons were unaffected by changes in amplitude and duration of CF-FM stimuli. However, the excitability of DO neurons increased with prolonged CF duration and higher amplitude of CF-FM stimuli. These data suggested that the invariance of SO neurons play a key role in detection of Doppler shift and glint-like changes of frequency and amplitude induced by wingbeats of insects. In contrast, amplitude- and duration-sensitivity of DO neurons to CF-FM stimuli is consistent with the systematic changes in these signal parameters during sequential phases of foraging in CF-FM bats.
作者：
Wang Qiao-Chao;Kong Hui-Fang;Cheng Ya-Wen;Wang Hui-Mei;Fu Zi-Ying（付子英）;...
期刊：
生物化学与生物物理进展,2018年45(7):723-735 ISSN：1000-3282
通讯作者：
Tang Jia
作者机构：
[Tang Jia] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Tang Jia] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.
作者机构：
[Chen, Qi-Cai] Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Peoples R China.
通讯机构：
[Chen, Qi-Cai] C;Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.
摘要：
In the auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from the lower auditory nuclei, contralateral IC, and auditory cortex (AC), and then uploads these inputs to the thalamus and cortex. Meanwhile, the AC modulates the sound signal processing of IC neurons, including their latency (i.e., first-spike latency). Excitatory and inhibitory corticofugal projections to the IC may shorten and prolong the latency of IC neurons, respectively. However, the synaptic mechanisms underlying the corticofugal latency modulation of IC neurons remain unclear. Thus, this study probed these mechanisms via in vivo intracellular recording and acoustic and focal electric stimulation. The AC latency modulation of IC neurons is possibly mediated by pre-spike depolarization duration, pre-spike hyperpolarization duration, and spike onset time. This study suggests an effective strategy for the timing sequence determination of auditory information uploaded to the thalamus and cortex.
作者机构：
[Chen, Qi-Cai] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Chen, Qi-Cai] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.
关键词：
Recovery cycle;Inter-pulse interval;Doppler-shift compensation;Inferior collicular neuron;CF-FM bat
摘要：
The Doppler-shift compensation (DSC) behavior of constant frequency - frequency modulation (CF-FM) bat (Hipposideros pratti) is vital for extraction and analysis of echo information. This type of behavior affects the recovery cycles of sound-sensitive neurons, but their precise relationship remains unclear. In this study, we investigated the effects of DSC on the recovery cycles of inferior collicular (IC) neurons in H. pratti. We simulated the pulse-echo pair in bats by changing the emitted pulse frequency and keeping the echo frequency constant during DSC in echolocation. The neuronal recovery cycles of IC neurons are categorized into four types: unrecovered, monotonic, single-peak, and multi-peak. The recovery cycle of IC neurons shortens after DSC; moreover, the amount of neurons with multi-peak recovery cycle increases and concentrates in the short recovery area. This paper also discusses the possible neural mechanisms and their biological relevance to different phases of bat predation behavior. (C) 2017 Elsevier Inc. All rights reserved.
作者机构：
[Zhou, Yanping; Song, Dandan; Cui, Yanfang; Xu, Shan] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Hu, Sheng; Tang, Jing; Zhu, Xianmin] Hubei Prov Tumor Hosp, Dept Med Oncol, Wuhan 430079, Hubei, Peoples R China.;[Geng, Hui] Cent China Normal Univ, Dept Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Xu, Shan] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.;[Xu, Shan] Univ Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan,CAS Key Lab Magne, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China.
通讯机构：
[Cui, Yanfang] C;[Hu, Sheng] H;[Cui, Yanfang] M;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;Hubei Prov Tumor Hosp, Dept Med Oncol, Wuhan 430079, Hubei, Peoples R China.
摘要：
Most lung cancers are diagnosed at fairly advanced stages due to limited clinical symptoms. Platinum-based chemotherapy, either as single regimen or in combination with radiation, is one of the major recommendations for the patients. Earlier evaluation of the effectiveness of the chemotherapies is critical for developing better treatment plan given the toxicity of the chemotherapeutic reagents. Drug efficacy could be reflected in the systemic metabolism characteristics though knowledge about which remains scarce. In this study, serum metabolism influence of three types of commonly used platinum-based combination chemotherapy regimens, namely cisplatin with gemcitabine, vinorelbine or docetaxel, were studied using pattern recognition coupled with nuclear magnetic resonance techniques. The treated patients were divided into sensitive or insensitive subgroups according to their response to the treatments. We found that insensitive subjects can be identified from the sensitive ones with up-regulation of glucose and taurine but reduced alanine and lactate concentrations in serum. The combination chemotherapy of lung cancer is accompanied by disturbances of multiple metabolic pathways such as energy metabolism, phosphatidylcholine biosynthesis, so that the treated patients were marginally discriminated from the untreated. Serum metabolic profile of patients shows potential as an indicator of their response to platinum-based combination chemotherapy.
摘要：
Currently, there is limited information about the relationship between manganese superoxide dismutase (sod2) c47t polymorphism and susceptibility to noise-induced hearing loss (NIHL).
The aim of this meta-analysis was to clarify the association between SOD2 C47T polymorphism and NIHL.
A search in PubMed and Web of Science was performed to collect data. All full-text, English-written studies containing sufficient and complete case-and-control data about the relationship between SOD2 C47T polymorphism and NIHL were included. Three eligible studies, comprising 1094 subjects, were identified. pooled odds ratios (ORs) and 95% confidence intervals (CI) were calculated to evaluate the strength of the association between SOD2 C47T polymorphism and NIHL.
No significant association between C47T polymorphism and risk of NIHL was found with the following combinations: T vs. C (OR = 0.83; 95% CI = 0.63–1.09); TT vs. CC (OR = 0.49; 95% CI = 0.22–1.09); CT vs. CC (OR = 0.54; 95% CI = 0.25–1.17); TT vs. CC + CT (OR = 0.82; 95% CI = 0.50–1.32); CC vs. TT + TC (OR = 0.49; 95% CI = 0.23–1.04). However, in subgroup analysis, a significant association was found for TT vs. CC + CT (OR = 0.77; 95% CI = 0.42–1.41) in the Chinese population.
The present meta-analysis suggests that SOD2 C47T polymorphism is significantly associated with increased risk of NIHL in the Chinese population. Further large and well-designed studies are needed to confirm this association.
Atualmente, são limitadas as informações acerca da relação entre o polimorfismo C47T de superóxido dismutase 2 (SOD2) dependente de manganês e suscetibilidade à perda auditiva induzida pelo ruído (PAIR).
O objetivo desta metanálise foi esclarecer a associação entre o polimorfismo C47T de SOD2 e PAIR.
Foi realizadas buscas no PubMed e Web of Science para coleta de dados. Foram incluídos todos os estudos no idioma inglês, contendo dados suficientes e completos de casos e controles sobre a relação entre o polimorfismo C47T de SOD2 e PAIR. Foram identificados três estudos qualificados, abrangendo 1.094 indivíduos. Foram calculadas as razões das chances (odds ratio, OR) acumuladas e intervalos de confiança (IC) de 95% para que fosse avaliada a potência da associação entre o polimorfismo C47T de SOD2 e PAIR.
Não foi encontrada uma associação significativa entre o polimorfismo C47T de SOD2 e risco de PAIR com as seguintes combinações: T vs. C (OR = 0,83, IC 95% = 0,63-1,09); TT vs. CC (OR = 0,49, IC 95% = 0,22-1,09); CT vs. CC (OR = 0,54, IC 95% = 0,25-1,17); TT vs. CC + CT (OR = 0,82, IC 95% = 0,50-1,32); CC vs. TT + TC (OR = 0,49, IC 95% = 0,23-1,04). Contudo, na análise de subgrupo, foi encontrada uma associação significativa para TT vs. CC + CT (OR = 0,77, 95% CI = 0,42-1.41) na população chinesa.
A presente metanálise sugere que o polimorfismo C47T de SOD2 demonstra associação significativa com maior risco de PAIR na população chinesa. Há necessidade de novos estudos de grande porte bem concebidos, para confirmação dessa associação.
摘要：
目的先前的研究发现,在行为相关的CF-FM声刺激下,CF-FM蝙蝠的下丘(inferior colliculus,IC)神经元显示出要么产生单反应(single-on,SO),要么产生双反应(double-on,DO)(Fu et al.,2010;Tang et al.,2011;Li et al.,2015)。两类神经元对行为相关声信号的频率选择性是否不同?尚需研究。方法 10只普氏蹄蝠(Hi
作者机构：
[Fu, Zi-Ying; Chen, Qi-Cai; Tang, Jia; Mei, Hui-Xian; Cheng, Liang] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.;[Fu, Zi-Ying; Chen, Qi-Cai; Tang, Jia; Mei, Hui-Xian; Cheng, Liang] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.;[Mei, Hui-Xian] Hubei Univ, Sch Sport, Wuhan 430062, Peoples R China.;[Cheng, Liang] CCNU, Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan 430079, Peoples R China.;[Cheng, Liang] Cent China Normal Univ, Sch Psychol, Wuhan 430079, Peoples R China.
通讯机构：
[Chen, Qi-Cai] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
作者：
Kang Peng;Zi-Ying Fu（付子英）;Jia Tang;Ming-Jian Yang;Jing Wang;...
作者机构：
[Zi-Ying Fu; Kang Peng; Jia Tang; Ming-Jian Yang; Jing Wang; Qi-Cai Chen] School of Life Sciences,Central China Normal University
会议名称：
2016年国际生理学学术大会
会议时间：
2016-09-25
会议地点：
中国北京
会议论文集名称：
2016年国际生理学学术大会论文集
关键词：
behavior-related sound signal;auditory midbrain;CF-FM bat
摘要：
The CF-FM signal emitted by CF-FM bats may be called "a simple-complex sound signal",which CF and FM components have different function during echolocation（O’Neill & Suga,1982; Kober et al.,1990; Fu et al.,2010; Schnitzler & Denzinger,2011; Jakobsen et al.,2013）.How to process the complex and behavior-related sound signals in the auditory system is known very little up to now.Therefore,the study on the cellular basis and mechanism of the CF-FM sound signal processing in the auditory system have the very important significance for our further understanding complex sound signal processing.Because CF-FM signal used in the study simulates the echolocation call of the CF-FM bat（Hipposideros pratti）,it is thought to be a behavior-related sound signal.We investigated the CF-FM sound signal processing in auditory midbrains（i.e.inferior colliculus,IC） of the CF-FM bat（Hipposideros pratti）,FM bat（Pipistrellus abramus） and mouse（Mus musculus,Km） using the intracellular,extracellular and auditory evoked potential recordings and compared the modes of CF-FM signal processing in three animal species.Total 145 sound-sensitive neurons were isolated from the ICs of 7 CF-FM bats using extracellular recording.According to their response patterns to CF-FM stimulus,the recorded neurons could be classified into two types,i.e.single-on（SO）（56%,N=102/182） and double-on（DO） responders（44%,N=80/182）.In addition,178 neurons were intracellularly isolated from the IC of 6 CF-FM bats and 130 among the neurons were examined with CF-FM sounds.67.7%（88/130） of the neurons were SO neurons and the remains（32.3%,42/130） were DO neurons.In addition,we also did the comparative study on the response patterns to CF-FM stimulus in CF-FM bats,FM bats and mice.These results showed that the behavior-related SO and DO response patterns to CF-FM stimulus have formed in the auditory centers of the CF-FM bats and these two response patterns appeared the species-specificity in three animal species.
